Upregulation of Membrane-Bound CD40L on CD4+T cells in Women with Primary Sjögren's Syndrome

2013 ◽  
Vol 79 (1) ◽  
pp. 37-42 ◽  
Author(s):  
R. Belkhir ◽  
N. Gestermann ◽  
M. Koutero ◽  
R. Seror ◽  
J. Tost ◽  
...  
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Primary Sjögren’S Syndrome ◽  
Primary Sjogren’S Syndrome ◽  
Primary Sjögren's Syndrome ◽  
Membrane Bound ◽  
Sjögren‘S Syndrome

scholarly journals Multiomic disease signatures converge to cytotoxic CD8 T cells in primary Sjögren’s syndrome

2017 ◽  
Vol 76 (8) ◽  
pp. 1458-1466 ◽  
Author(s):  
Shinya Tasaki ◽  
Katsuya Suzuki ◽  
Ayumi Nishikawa ◽  
Yoshiaki Kassai ◽  
Maiko Takiguchi ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Primary Sjögren’S Syndrome ◽  
Primary Sjogren’S Syndrome ◽  
Primary Sjögren's Syndrome ◽  
Gene Signatures ◽  
Sjögren‘S Syndrome

ObjectivesMultiomics study was conducted to elucidate the crucial molecular mechanisms of primary Sjögren’s syndrome (SS) pathology.MethodsWe generated multiple data set from well-defined patients with SS, which includes whole-blood transcriptomes, serum proteomes and peripheral immunophenotyping. Based on our newly generated data, we performed an extensive bioinformatic investigation.ResultsOur integrative analysis identified SS gene signatures (SGS) dysregulated in widespread omics layers, including epigenomes, mRNAs and proteins. SGS predominantly involved the interferon signature and ADAMs substrates. Besides, SGS was significantly overlapped with SS-causing genes indicated by a genome-wide association study and expression trait loci analyses. Combining the molecular signatures with immunophenotypic profiles revealed that cytotoxic CD8 ­T cells­ were associated with SGS. Further, we observed the activation of SGS in cytotoxic CD8 T cells isolated from patients with SS.ConclusionsOur multiomics investigation identified gene signatures deeply associated with SS pathology and showed the involvement of cytotoxic CD8 T cells. These integrative relations across multiple layers will facilitate our understanding of SS at the system level.

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