Do the high‐protein recommendations for athletes set some on a path to kidney injury and dialysis?

Long Term High Protein Diet Feeding Alters the Microbiome and Increases Intestinal Permeability, Systemic Inflammation and Kidney Injury in Mice

Molecular Nutrition & Food Research ◽

10.1002/mnfr.202000851 ◽

2021 ◽

pp. 2000851

Author(s):

Matthew Snelson ◽

Rachel Elise Clarke ◽

Tuong‐Vi Nguyen ◽

Sally Anne Penfold ◽

Josephine Maree Forbes ◽

...

Keyword(s):

Intestinal Permeability ◽

Systemic Inflammation ◽

Kidney Injury ◽

High Protein Diet ◽

High Protein ◽

Protein Diet

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Fermented Feed Supplement Relieves Caecal Microbiota Dysbiosis and Kidney Injury Caused by High-Protein Diet in the Development of Gosling Gout

Animals ◽

10.3390/ani10112139 ◽

2020 ◽

Vol 10 (11) ◽

pp. 2139

Author(s):

Yumeng Xi ◽

Yuanpi Huang ◽

Ying Li ◽

Junshu Yan ◽

Zhendan Shi

Keyword(s):

Dietary Protein ◽

Kidney Injury ◽

High Protein Diet ◽

High Protein ◽

Protein Diet ◽

Feed Supplement ◽

Protein Levels ◽

Fermented Feed ◽

High Protein Diets ◽

Protein Diets

Firstly, forty-eight 1-day-old goslings were randomly allocated to four groups and were fed diets containing crude protein (CP) at different concentrations: 160, 180, 200, and 220 g/kg in Experiment One. We found a dose-dependent relationship between the dietary protein levels and morbidity of gosling gout. The concentration of serum uric acid (UA), creatinine (Cr), and urea nitrogen (UN), and the activity of xanthine oxidase in the 220CP groups were significantly higher than those in the low-protein diet groups. Beneficial microbes, including Akkermansia, Lactococcus, and Butyricicoccus were enriched in the ceca of healthy goslings, while the microbes Enterococcus, Enterobacteriaceae, and Bacteroides were enriched in those with gout. Then, we explored the effects of fermented feed on gosling gout caused by high-protein diets in Experiment Two. A total of 720 1-day-old goslings were randomly allotted to four experimental groups: CN (162.9 g/kg CP), CNF (167.5 g/kg CP, replacing 50 g/kg of the basal diet with fermented feed), HP (229.7 g/kg CP, a high-protein diet), and HPF (230.7 g/kg CP, replacing 50 g/kg of the high-protein diet with fermented feed). We found that the cumulative incidence of gout increased in the HP group compared with that in the control, but decreased in the HPF group compared to that in the HP group. Similarly, the concentration of serum UA in the HP group was higher than that in the CN group, but decreased in the HPF group. Meanwhile, compared with the HP group, using fermented feed in diets decreased the abundance of Enterococcus in the ceca of goslings, while increasing the abundance of Lactobacillus. These results suggest that appropriate dietary protein levels and the fermented feed supplement might relieve the kidney injury and gut microbiota dysbiosis caused by high-protein diets in the development of gosling gout.

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