scholarly journals Analgesic effects of indomethacin spray on drug‐induced oral mucositis pain in patients with cancer: A single‐arm cross‐sectional study

2021 ◽  
Author(s):  
Hironobu Hata ◽  
Shinya Takada ◽  
Jun Sato ◽  
Kazuhito Yoshikawa ◽  
Kenji Imamachi ◽  
...  
The Lancet ◽  
2021 ◽  
Vol 398 ◽  
pp. S11
Author(s):  
Mohammad N Alswerki ◽  
Abdallah Alwali ◽  
Alaa Al-aqad ◽  
Mahmoud Hamouda ◽  
Saad Al massri ◽  
...  

2020 ◽  
Vol 63 (4) ◽  
pp. 480-489
Author(s):  
Reeta Mahey ◽  
Shobha Kandpal ◽  
Monica Gupta ◽  
Perumal Vanamail ◽  
Neerja Bhatla ◽  
...  

2015 ◽  
Vol 8 (3-4) ◽  
pp. 216-221 ◽  
Author(s):  
Suparna Chatterjee ◽  
Gur Prasad Dureja ◽  
Ganesh Kadhe ◽  
Amey Mane ◽  
Abhay A. Phansalkar ◽  
...  

2021 ◽  
Vol 7 (2) ◽  
pp. 64-70
Author(s):  
Emre YEKEDÜZ ◽  
Elif Berna KÖKSOY ◽  
Satı Coşkun YAZGAN ◽  
Ilgın AKBIYIK ◽  
Sevinç BALLI ◽  
...  

2018 ◽  
Vol 4 (Supplement 1) ◽  
pp. 15s-15s
Author(s):  
Sewunet Admasu Belachew ◽  
Daniel Asfaw Erku ◽  
Abebe Basazn Mekuria ◽  
Begashaw Melaku Gebresillassie

Abstract 32 Purpose Adverse drug reactions (ADRs) are a global problem and constitute a major clinical problem in terms of human suffering. The high toxicity and narrow therapeutic index of chemotherapeutic agents makes oncology pharmacovigilance essential. The objective of the current study was to assess the pattern of ADRs that occur in patients with cancer who were treated with chemotherapy in a tertiary care teaching hospital in Ethiopia. Methods A cross-sectional study over a 2-year period from September 2013 to August 2015 was conducted in patients with cancer who underwent chemotherapy at Gondar University Referral Hospital Oncology Center. Data were collected directly from patients and their medical case files. Reported ADRs were assessed for causality using the WHO causality assessment scale and Naranjo’s algorithm. Severities of the reported reactions were also assessed using National Cancer Institute Common Terminology Criteria for Adverse Events (version 4.0). Pearson’s χ2 test was used to examine the association between two categorical variables. Results A total of 815 ADRs were identified from 203 patients who were included in the study. The most commonly occurring ADRs were nausea and vomiting (18.9%), infections (16.7%), neutropenia (14.7%), fever and/or chills (11.3%), and anemia (9.3%). Platinum compounds (31.4%) were the most common group of drugs that caused ADRs. Of reported ADRs, 65.8% were grades 3 to 4 (severe level), 29.9% were grades 1 to 2 (mild level), and 4.3% were grade 5 (toxic level). Significant association was found between age, number of chemotherapeutic agents, and dose of chemotherapy with the occurrence of grades 3 to 5 toxicity. Conclusion The high incidence of chemotherapy-related ADRs among patients with cancer is of concern. Establishing an effective ADR monitoring and reporting system—oncopharmacovigilance—and creating awareness among health care professionals of the importance of ADR reporting may help prevent the problem. AUTHORS' DISCLOSURES OF POTENTIAL CONFLICTS OF INTEREST No COIs from the authors.


2019 ◽  
Vol 26 (1) ◽  
pp. 107327481986464 ◽  
Author(s):  
Dung Viet Truong ◽  
Quyen Thi Tu Bui ◽  
Do Tri Nguyen ◽  
Jaleesa Moore

Anxiety, a condition which is commonly found in patients with cancer, has negative impacts on their quality of life and treatment outcome. This study aimed to determine the level of anxiety in patients with cancer and explore sociodemographic, disease-related, and hospital-related factors associated with anxiety in those patients. A cross-sectional study was conducted on 510 inpatients with cancer at Thanh Hoa Oncology Hospital, Vietnam. Data were collected from self-administered questionnaire forms on hospital depression anxiety-A, interviews with patients, and patient medical records. The univariate and multivariate linear regression analyses were performed using STATA ver. 14.0. Our finding that the patients’ mean anxiety score (standard deviation) was 7.22 (3.8); 27.6% of the patients had an anxiety score between 8 and 10 points, and 15.5% had an anxiety score of ≥11 points. In the multivariate model, in more advanced stages of cancer, and patients with metastasis were more likely to have higher levels of anxiety than those who presented no sign of metastasis. The longer the patients had cancer, the less anxious they became. Lower levels of anxiety were observed in patients who stated that hospital facilities were adequate or had trust in health workers. Patients with cancer need to be provided with psychological support in the early stage of cancer detection and when metastases form. A strong patient–health-care provider relationship after diagnosis may help reduce distress among patients with cancer with higher levels of medical mistrust.


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