Reduced salivary flow rate and high levels of oxidative stress in whole saliva of children with Down syndrome

2017 ◽  
Vol 37 (6) ◽  
pp. 269-276 ◽  
Author(s):  
Natália Bertolo Domingues ◽  
Matheus Racy Mariusso ◽  
Marcia Hiromi Tanaka ◽  
Raquel Mantuaneli Scarel-Caminaga ◽  
Marcia Pinto Alves Mayer ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Down Syndrome ◽  
Flow Rate ◽  
Salivary Flow ◽  
Salivary Flow Rate ◽  
Children With Down Syndrome ◽  
Whole Saliva

Comparison of Whole Saliva Flow Rates and Mucin Concentrations in Healthy Caucasian Young and Aged Adults

1992 ◽  
Vol 71 (6) ◽  
pp. 1275-1278 ◽  
Author(s):  
M. Navazesh ◽  
R.A. Mulligan ◽  
V. Kipnis ◽  
P.A. Denny ◽  
P.C. Denny
Keyword(s):  
Flow Rate ◽  
Salivary Flow ◽  
Young Group ◽  
Salivary Flow Rate ◽  
Flow Rates ◽  
Aged Group ◽  
Whole Saliva ◽  
Saliva Flow

Unstimulated and chewing-stimulated whole saliva samples were obtained from 42 healthy Caucasians; 21 were between 18 and 35 years of age, and 21 between 65 and 83 years of age. The unstimulated salivary flow rate was significantly lower in the aged group, but the stimulated flow rate was significantly higher in the aged than in the young group. Both groups showed significantly increased flow during salivary stimulation. MG1 and MG2 concentrations in unstimulated and stimulated saliva samples were significantly lower in the aged group. There were no significant correlations between salivary flow rates and MG1 and MG2 concentrations.

scholarly journals Analysis of the relationship between human cytomegalovirus DNA and gB-1 genotype in the saliva of HIV/AIDS patients with xerostomia and salivary flow rate

2019 ◽  
Vol 52 (4) ◽  
pp. 197
Author(s):  
Irna Sufiawati ◽  
S. Suniti ◽  
Revi Nelonda ◽  
Rudi Wisaksana ◽  
Agnes Rengga Rendati ◽  
...  
Keyword(s):  
Human Cytomegalovirus ◽  
Flow Rate ◽  
Salivary Flow ◽  
Cross Sectional Study ◽  
Salivary Flow Rate ◽  
Research Subjects ◽  
Aids Patients ◽  
Cross Sectional ◽  
Whole Saliva ◽  
Hiv Aids

Background: Human immunodeficiency virus (HIV) infection increases vulnerability to opportunistic viral infection, including Human cytomegalovirus (HCMV) infection, that has been detected in saliva. The HCMV envelope glycoprotein B (gB) is highly immunogenic and has been associated with HCMV-related diseases. Purpose: The purpose of this study is to assess the prevalence of HCMV and gB-1 genotype in the saliva of HIV/AIDS patients and to analyse their relationship with xerostomia and salivary flow rate (SFR). Methods: This cross-sectional study involved 34 HIV/AIDS patients. Saliva was tested for the presence of HCMV DNA using PCR microarrays, and nested PCR for gB-1 genotype detection. Xerostomia was measured using a Fox’s questionnaire. Unstimulated whole saliva flow rate was measured by means of the spitting method. Results: The composition of the research population consisting of 73.5% males and 26.5% females with HIV/AIDS. HCMV was found in 64.7% of HIV/AIDS patients, while gB-1 genotype was detected in 59.1%. Xerostomia was closely associated with the presence of HCMV in saliva (p<0.05), but not with gB-1. There was no significant relationship between xerostomia and SFR rates in the research subjects with HCMV positive saliva (p> 0.05). Conclusion: The presence of xerostomia-associated HCMV in saliva was elevated among HIV/AIDS patients. Further investigation is required to identify other gB genotypes that may be responsible for xerostomia and SFR changes in HIV/AIDS patients.

scholarly journals Saliva diagnostic utility in patients with type 2 diabetes: Future standard method

2019 ◽  
Vol 0 (0) ◽  
Author(s):  
Marwa Mrag ◽  
Asma Kassab ◽  
Asma Omezzine ◽  
Raoua Belkacem Chebil ◽  
Fatma Ben Fredj Ismail ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Flow Rate ◽  
Total Protein ◽  
Immunoglobulin A ◽  
Salivary Flow ◽  
Salivary Flow Rate ◽  
Oral Exam ◽  
Whole Saliva ◽  
Significant Difference

Summary Background The purpose of the present study was to assess saliva reliability in diagnosis and monitoring type 2 diabetes instead of blood. Methods Blood and unstimulated whole saliva were collected from 300 type 2 diabetic subjects and 300 healthy controls in fasting. Then, the salivary flow rate was calculated. All parameters including glucose, urea, amylase, total protein, albumin, C-reactive protein (CRP), immunoglobulin A (IgA), potassium, calcium and chloride were assessed in the supernatant, using an autoanalyzer. Oral exam was conducted by a single examiner on full mouth excluding third molars. Statistical analysis was performed by the SPSS 20.0 version. Results Saliva screening showed that glucose, urea, amylase, total protein, potassium, calcium and chloride were significantly higher in patients compared to controls (p < 0.05). Whereas, the IgA level and salivary flow rate were significantly reduced in patients (p < 0.05). No significant difference was found in albumin and CRP levels (p = 0.05). There was a significant positive correlation between salivary and plasma glucose levels (r = 0.887, and r = 0.900, p < 0.001), as well as, salivary and blood urea (r = 0.586, and r = 0.688, p < 0.001) in patients and controls, respectively. Conclusions From this study, saliva could be suggested as a useful diagnostic tool for type 2 diabetes.

scholarly journals Variations of salivary flow rates in Brazilian school children

2006 ◽  
Vol 20 (1) ◽  
pp. 8-12 ◽  
Author(s):  
Sandra Regina Torres ◽  
Marcio Nucci ◽  
Estevão Milanos ◽  
Renata Pessoa Pereira ◽  
Alessandra Massaud ◽  
...  
Keyword(s):  
Public Schools ◽  
Health Status ◽  
Flow Rate ◽  
School Children ◽  
Medical Records ◽  
Salivary Flow ◽  
Salivary Flow Rate ◽  
Healthy Individuals ◽  
Flow Rates ◽  
Whole Saliva

The salivary flow rate (SFR) in healthy individuals may vary according to different factors. There is a scarcity of studies from different geographical areas that analyze SFR variations in children. The aim of this study was to verify stimulated salivary flow rate (SFR) variations in 6 to 12-year-old children, from four different public schools of Rio de Janeiro and correlate these data to gender, age, type of dentition, and health status. Clinical data were taken from the children's medical records that were kept at those schools. Oral examination and sialometry were performed in every child. Salivary flow rate was obtained by chewing-stimulated whole saliva under standard conditions. There were significant differences in SFR according to age (p = 0.0003). Six and 12-year-old children showed the lowest SFR, and when they were excluded from the analysis, no significant differences were found (p = 0.21). There were also significant differences in SFR among children from different public schools (p = 0.0009). The gender did not show any correlation to SFR, even when children were stratified by age (p = 0.36). Correlation between SFR and deciduous, mixed or permanent dentition was not found as well. These results show that the analyzed clinical variables did not seem to influence SFR in this children population.

scholarly journals Evaluation of the Salivary Flow Rate and pH in Patients with Recurrent Oral Ulcers

2020 ◽  
Vol 17 (2) ◽  
Author(s):  
Mustafa Al-Ahmad ◽  
Basma Ezzat ◽  
Sukmasari S ◽  
Abdul Jabbar O
Keyword(s):  
Flow Rate ◽  
Saliva Sample ◽  
Salivary Flow ◽  
Salivary Flow Rate ◽  
Aphthous Ulcer ◽  
Control Group ◽  
P Value ◽  
Health Maintenance ◽  
Oral Ulcers ◽  
Whole Saliva

Introductions: Recurrent oral ulcers primarily effect mucosal surfaces and are among the most common chronic inflammatory diseases. Numerous studies to find the aetiopathogenesis have been conducted however the cause still remains unclear. Saliva is of utmostimportance for oral health maintenance. In current study, saliva was used as a diagnostic tool for comparison of salivary flow rate and pH in patients suffering from recurrent oral ulcers and control group. Materials and Methods: Saliva samples taken from 20 recurrent aphthous ulcer patients and 20 control (healthy) patients using a convient sampling method. Drooling method was used to collect unstimulated whole saliva sample. Pre-weighted specimen bottles were used and then weighed after sample collection on a graduated scale where as chair-side pH meter was used to determine the salivary pH. Independent t-test and Pearson’s correlation were performed. A p-value of less than 0.05 was considered statistically significance. Results: Positive correlation was found between the flow rate and pH in recurrent oral ulcer patients. Patients with recurrent oral ulcers had higher flow rate and pH compared to the control group. These effects were exaggerated in female patients with ulcers. Conclusions: Disturbances in salivary flow rate and pH were not significantly associated with recurrent oral ulcers.

Physiological Factors Affecting Salivary Flow Rate, Oral Sugar Clearance, and the Sensation of Dry Mouth in Man

1987 ◽  
Vol 66 (2_suppl) ◽  
pp. 648-653 ◽  
Author(s):  
C. Dawes
Keyword(s):  
Flow Rate ◽  
Salivary Flow ◽  
Salivary Flow Rate ◽  
Dry Mouth ◽  
Physiological Factors ◽  
Physiological Basis ◽  
Factors Affecting ◽  
Physiological Variables ◽  
Normal Ranges ◽  
Whole Saliva

This paper discusses methods for collection of both whole saliva and individual gland secretions, the normal ranges of salivary flow rate, the effects of physiological variables which influence flow rate, and the role of saliva in oral sugar clearance. The physiological basis for the sensation of dry mouth is discussed, and a new concept is advanced which states that the sensation of dry mouth will occur when the salivary flow rate is less than the sum of the rates of water absorption and evaporation from the mouth. In a study of the effects of anticholinergic agents on salivary flow, the subjects experienced the sensation of dry mouth when the normal flow rate of unstimulated saliva was reduced by from 40 to 50%.

Stimulated parotid salivary flow rate in patients with Down syndrome

2002 ◽  
Vol 22 (1) ◽  
pp. 41-44 ◽  
Author(s):  
Stella Chaushu ◽  
Adrian Becker ◽  
Gabriel Chaushu ◽  
Joseph Shapiro
Keyword(s):  
Down Syndrome ◽  
Flow Rate ◽  
Salivary Flow ◽  
Salivary Flow Rate

On the Relationship between the Rate of Salivary Flow and Salivary Fluoride Clearance

2015 ◽  
Vol 49 (2) ◽  
pp. 141-146 ◽  
Author(s):  
Ralph M. Duckworth ◽  
S. Jones
Keyword(s):  
Flow Rate ◽  
Salivary Flow ◽  
Salivary Flow Rate ◽  
Time Of Application ◽  
Saliva Flow Rate ◽  
Whole Saliva ◽  
Observed Behaviour ◽  
Saliva Flow ◽  
Unstimulated Whole Saliva ◽  
The Relationship

The amount of fluoride retained in the mouth following the application of dentifrices, mouthwashes, etc. may be important in determining their anticaries efficacy. In this study we investigated the relationship between the salivary flow rate and salivary fluoride clearance. Ten adults tested six mouthrinses, consisting of aqueous sodium fluoride solutions (0.013, 0.026 mol/l) with and without added sodium chloride (1.28 mol/l) or sucrose (0.44 mol/l), in a randomised order. Prior to each test, subjects swallowed, rinsed for 2 min with 2 ml water and then expectorated into a preweighed container to obtain a measure of initial saliva flow rate. Next, the procedure was repeated using one of the test rinses. Finally, samples of unstimulated whole saliva were collected for up to 3 h after each mouthrinse application and analysed for fluoride. Salivary fluoride concentrations were significantly lower after application of mouthrinses that contained either sucrose or NaCl, both of which compounds markedly enhanced salivary flow, than after the use of corresponding mouthrinses without any additive. Area under the salivary fluoride clearance curve (AUC) values were inversely correlated with salivary flow rate on an individual basis (p < 0.01). The observed behaviour could not be completely attributed to treatment dilution by saliva at the time of application.

Salivary flow rate and biochemical composition analysis in stimulated whole saliva of children with cystic fibrosis

2015 ◽  
Vol 60 (11) ◽  
pp. 1650-1654 ◽  
Author(s):  
Karine Barros da Silva Modesto ◽  
Jéssica Bueno de Godói Simões ◽  
Amanda Ferreira de Souza ◽  
Neiva Damaceno ◽  
Danilo Antonio Duarte ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Flow Rate ◽  
Biochemical Composition ◽  
Salivary Flow ◽  
Salivary Flow Rate ◽  
Composition Analysis ◽  
Whole Saliva

scholarly journals The prevalence of hyposalivation in type 2 diabetes mellitus patients at Endocrinology Department, Internal Medicine Sub Department of RSUP Dr Hasan Sadikin Bandung

2013 ◽  
Vol 25 (3) ◽  
Author(s):  
Marini Sundari ◽  
Tenny Setiani Dewi ◽  
Nanny Natalia
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Flow Rate ◽  
Objective Assessment ◽  
Diabetes Mellitus Patient ◽  
Salivary Flow ◽  
Salivary Flow Rate ◽  
Whole Saliva

Introduction: The salivary flow rate reduces Hyposalivation. Type 2 diabetes mellitus patient with hyposalivation have a high risk of various oral complications if untreated adequately. The aim of this study was to find the prevalence of hyposalivation in type 2 diabetes mellitus patient at RSUP Dr Hasan Sadikin Bandung. Methods: This study was a descriptive observational with a cross-sectional approach and consecutive sampling method to 30 samples. The study was performed with objective assessment through measuring the unstimulated salivary flow of the whole saliva using spitting method for 5 minutes. Results: The result of this study shows that the prevalence of hyposalivation on type 2 diabetes mellitus patient is 10%. The mean of salivary flow rate sample with hyposalivation is 0,07 mL/minute. Conclusion: The conclusion of this study shows a low prevalence of hyposalivation in type 2 diabetes mellitus patients at RSUP Dr Hasan Sadikin Bandung in October 2011.

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