Oral squamous cell carcinoma in two siblings with Fanconi anemia after allogeneic bone marrow transplantation

2013 ◽  
Vol 34 (4) ◽  
pp. 212-215 ◽  
Author(s):  
Cassius Carvalho Torres-Pereira ◽  
Roberta Targa Stramandinoli-Zanicotti ◽  
José Miguel Amenábar ◽  
Laurindo Moacir Sassi ◽  
Paola Andrea Galbiatti Pedruzzi ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Squamous Cell Carcinoma ◽  
Bone Marrow Transplantation ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Fanconi Anemia ◽  
Marrow Transplantation ◽  
Allogeneic Bone Marrow Transplantation ◽  
Allogeneic Bone

scholarly journals Fanconi Anemia: main oral manifestations

2014 ◽  
Vol 62 (3) ◽  
pp. 281-288 ◽  
Author(s):  
Anna Clara Duszczak D'AGULHAM ◽  
Cassiano Lima CHAIBEN ◽  
Antônio Adilson Soares de LIMA ◽  
Cassius Carvalho TORRES-PEREIRA ◽  
Maria Ângela Naval MACHADO
Keyword(s):  
Bone Marrow ◽  
Squamous Cell Carcinoma ◽  
Bone Marrow Transplantation ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Fanconi Anemia ◽  
Marrow Transplantation ◽  
Genetic Disorder ◽  
Oral Manifestations ◽  
Increased Risk

Fanconi Anemia is a recessive and rare genetic disorder, characterized by chromosomal instability that induces congenital alterations in individuals. Aplastic anemia due to the progressive failure of the bone marrow, malignant neoplasias such as acute myeloid leukemia, liver tumors and squamous cell carcinoma are some of the possible evolutions of Fanconi Anemia. Some of these diseases develop mainly after bone marrow transplantation. The aim of this critical review of the literature was to discourse about the main oral manifestations and their involvement in the health of individuals who are ill with Fanconi Anemia. The clinical oral findings described in the literature include periodontal changes, such as gingivitis and aggressive periodontitis, recurrent aphthous ulcers and traumatic lesions. Papillary atrophy, macroglossia, melanic pigmentation and squamous cell carcinoma are the most common oral manifestations on the tongue. An increased risk for the development of malignant neoplasias in individuals with Fanconi Anemia has been reported, and this is progressive after bone marrow transplantation. In radiographs, dental anomalies such as the presence of supernumerary teeth, tooth agenesis, tooth rotation and transposition of teeth are observed. Salivary flow and some salivary components are also altered. Due to the increased susceptibility to the development of cancer in this specific population, it is important for the dentist to know the common oral manifestations and potentially cancerous lesions, in order to make an early diagnosis in individuals with Fanconi Anemia.

scholarly journals Squamous cell carcinoma of the tongue after bone marrow transplantation in a patient with Fanconi anemia

2006 ◽  
Vol 17 (2) ◽  
pp. 161-165 ◽  
Author(s):  
Fernanda Gonçalves Salum ◽  
Gabriela Botelho Martins ◽  
Maria Antonia Zancanaro de Figueiredo ◽  
Karen Cherubini ◽  
Liliane Soares Yurgel ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Squamous Cell Carcinoma ◽  
Bone Marrow Transplantation ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Fanconi Anemia ◽  
Marrow Transplantation ◽  
Bone Marrow Failure ◽  
Oral Lesions ◽  
Carcinoma Of The Tongue

Fanconi anemia (FA) is an autosomal recessive disorder that might cause a variety of congenital and developmental abnormalities. The most important features of FA are progressive bone marrow failure and development of malignancies, particularly acute myeloid leukemia and solid tumors. This paper reports the case of a 12-year-old patient with FA assisted at the Stomatology and Bucomaxillofacial Cancer Prevention Service of São Lucas Hospital, Brazil, who had been submitted to bone marrow transplantation (BMT) at the age of 5 and exhibited oral lesions characteristic of chronic graft versus host disease (GVHD). The patient was treated and followed-up for the oral lesions. Eleven years after the BMT, he developed squamous cell carcinoma of the tongue with an aggressive behavior, which was considered an untreatable condition. The patient died few months later from asphyxia at the age of 16. The reasons for development of these malignant conditions are unknown. However, chromosomal instability typically observed in FA cases, BMT factors and GVHD have been considered. Systematic follow-up of these patients allows early and less invasive therapeutic approaches.

Immune reconstitution in patients with Fanconi anemia after allogeneic bone marrow transplantation

Cytotherapy ◽  
2014 ◽  
Vol 16 (7) ◽  
pp. 976-989 ◽  
Author(s):  
Miriam Perlingeiro Beltrame ◽  
Mariester Malvezzi ◽  
Carmem Bonfim ◽  
Dimas Tadeu Covas ◽  
Alberto Orfao ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Fanconi Anemia ◽  
Marrow Transplantation ◽  
Immune Reconstitution ◽  
Allogeneic Bone Marrow Transplantation ◽  
Allogeneic Bone Marrow ◽  
Allogeneic Bone

SQUAMOUS CELL CARCINOMAS AFTER ALLOGENEIC BONE MARROW TRANSPLANTATION FOR APLASTIC ANEMIA

1998 ◽  
Vol 66 (5) ◽  
pp. 667-670 ◽  
Author(s):  
G??rard Soci?? ◽  
Catherine Scieux ◽  
Eliane Gluckman ◽  
Thierry Soussi ◽  
Christine Clavel ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Aplastic Anemia ◽  
Squamous Cell ◽  
Marrow Transplantation ◽  
Allogeneic Bone Marrow Transplantation ◽  
Squamous Cell Carcinomas ◽  
Allogeneic Bone Marrow ◽  
Allogeneic Bone
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