scholarly journals A Benchmark Dose Analysis for Maternal Pregnancy Urine‐Fluoride and IQ in Children

Risk Analysis ◽  
2021 ◽  
Author(s):  
Philippe Grandjean ◽  
Howard Hu ◽  
Christine Till ◽  
Rivka Green ◽  
Morteza Bashash ◽  
...  
Keyword(s):  
Benchmark Dose ◽  
Pregnancy Urine

scholarly journals A Benchmark Dose Analysis for Maternal Pregnancy Urine-Fluoride and IQ in Children

2020 ◽  
Author(s):  
Philippe Grandjean ◽  
Howard Hu ◽  
Christine Till ◽  
Rivka Green ◽  
Morteza Bashash ◽  
...  
Keyword(s):  
Prospective Studies ◽  
Environmental Chemicals ◽  
Benchmark Dose ◽  
Exposure Level ◽  
Environmental Toxicants ◽  
Fluoride Exposure ◽  
Urinary Fluoride ◽  
Pregnancy Urine ◽  
Iq Scores ◽  
Linear Slope

AbstractAs a safe exposure level for fluoride in pregnancy has not been established, we used data from two prospective studies for benchmark dose modeling. We included mother-child pairs from the Early Life Exposures in Mexico to Environmental Toxicants (ELEMENT) cohort in Mexico and the Maternal-Infant Research on Environmental Chemicals (MIREC) cohort in Canada. Children were assessed for IQ at age 4 (n=211) and between 6 and 12 years (n=287) in the ELEMENT cohort and between ages 3 and 4 years (n=512) in the MIREC cohort. We calculated covariate-adjusted regression coefficients and their standard errors to explore the concentration-effect function for maternal urinary fluoride with children’s IQ, including possible sex-dependence. Assuming a benchmark response of 1 IQ point, we derived benchmark concentrations (BMCs) of maternal urinary fluoride and benchmark concentration levels (BMCLs). No deviation from linearity was detected from the results of the two studies. Using a linear slope, the BMC for maternal urinary fluoride associated with a 1-point decrease in IQ scores of preschool-aged boys and girls was 0.29 mg/L (BMCL, 0.18 mg/L). The BMC was 0.30 mg/L (BMCL, 0.19 mg/L) when pooling the IQ scores from the older ELEMENT children and the MIREC cohort. Boys showed slightly lower BMC values compared with girls. Relying on two prospective studies, maternal urine-fluoride exposure at levels commonly occurring in the general population, the joint data showed BMCL results about 0.2 mg/L. These results can be used to guide decisions on preventing excess fluoride exposure in vulnerable populations.

scholarly journals Benchmark Dose for Cadmium-Induced Renal Effects in Humans

2006 ◽  
Vol 114 (7) ◽  
pp. 1072-1076 ◽  
Author(s):  
Yasushi Suwazono ◽  
Salomon Sand ◽  
Marie Vahter ◽  
Agneta Falk Filipsson ◽  
Staffan Skerfving ◽  
...  
Keyword(s):  
Benchmark Dose ◽  
Renal Effects

scholarly journals Quantitative Risk Analysis for N-Methyl Pyrrolidone Using Physiologically Based Pharmacokinetic and Benchmark Dose Modeling

2009 ◽  
Vol 113 (2) ◽  
pp. 468-482 ◽  
Author(s):  
Torka S. Poet ◽  
Chris R. Kirman ◽  
Michael Bader ◽  
Christoph van Thriel ◽  
Michael L. Gargas ◽  
...  
Keyword(s):  
Risk Analysis ◽  
Benchmark Dose ◽  
Quantitative Risk Analysis ◽  
Physiologically Based Pharmacokinetic ◽  
Physiologically Based ◽  
Methyl Pyrrolidone

The Use of Benchmark Dose Methodology with Acute Inhalation Lethality Data

1999 ◽  
Vol 29 (3) ◽  
pp. 262-278 ◽  
Author(s):  
Jefferson R. Fowles ◽  
George V. Alexeeff ◽  
Daryn Dodge
Keyword(s):  
Benchmark Dose
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