scholarly journals Dose-Response Modeling with Summary Data from Developmental Toxicity Studies

Risk Analysis ◽  
2016 ◽  
Vol 37 (5) ◽  
pp. 905-917 ◽  
Author(s):  
John F. Fox ◽  
Karen A. Hogan ◽  
Allen Davis
Keyword(s):  
Dose Response ◽  
Developmental Toxicity ◽  
Toxicity Studies ◽  
Response Modeling ◽  
Summary Data

The developmental toxicity of inhaled methanol in the CD-1 mouse, with quantitative dose—response modeling for estimation of benchmark doses

Teratology ◽  
1993 ◽  
Vol 47 (3) ◽  
pp. 175-188 ◽  
Author(s):  
John M. Rogers ◽  
M. Leonard Mole ◽  
Neil Chernoff ◽  
Brenda D. Barbee ◽  
Christine I. Turner ◽  
...  
Keyword(s):  
Dose Response ◽  
Developmental Toxicity ◽  
Benchmark Doses ◽  
Response Modeling

scholarly journals Summary of Dose-Response Modeling for Developmental Toxicity Studies

Dose-Response ◽  
2008 ◽  
Vol 6 (4) ◽  
pp. dose-response.0 ◽  
Author(s):  
Daniel L. Hunt ◽  
Shesh N. Rai ◽  
Chin-Shang Li
Keyword(s):  
Risk Assessment ◽  
Dose Response ◽  
Response Pattern ◽  
Threshold Model ◽  
Developmental Toxicity ◽  
Discrete Distribution ◽  
Assessment Process ◽  
Future Research ◽  
Advantages And Disadvantages ◽  
Toxicity Studies

Developmental toxicity studies are an important area in the field of toxicology. Endpoints measured on fetuses include weight and indicators of death and malformation. Binary indicator measures are typically summed over the litter and a discrete distribution is assumed to model the number of adversely affected fetuses. Additionally, there is noticeable variation in the litter responses within dose groups that should be taken into account when modeling. Finally, the dose-response pattern in these studies exhibits a threshold effect. The threshold dose-response model is the default model for non-carcinogenic risk assessment, according to the USEPA, and is encouraged by the agency for the use in the risk assessment process. Two statistical models are proposed to estimate dose-response pattern of data from the developmental toxicity study: the threshold model and the spline model. The models were applied to two data sets. The advantages and disadvantages of these models, potential other models, and future research possibilities will be summarized.

Evaluation of Biologically Based Dose–Response Modeling for Developmental Toxicity: A Workshop Report

2000 ◽  
Vol 31 (2) ◽  
pp. 190-199 ◽  
Author(s):  
Christopher Lau ◽  
Melvin E. Andersen ◽  
Douglas J. Crawford-Brown ◽  
Robert J. Kavlock ◽  
Carole A. Kimmel ◽  
...  
Keyword(s):  
Dose Response ◽  
Developmental Toxicity ◽  
Workshop Report ◽  
Response Modeling

scholarly journals REPRODUCTIVE AND DEVELOPMENTAL TOXICITY STUDIES OF PRULIFLOXACIN (NM441) (4) : A Perinatal and Postnatal Study in Rats by Oral Administration

1996 ◽  
Vol 21 (SupplementI) ◽  
pp. 219-230 ◽  
Author(s):  
Tagahiko MORINAGA ◽  
Shigenobu FUJII ◽  
Shigenori FURUKAWA ◽  
Mikito KIKUMORI ◽  
Kimio YASUHIRA ◽  
...  
Keyword(s):  
Oral Administration ◽  
Developmental Toxicity ◽  
Toxicity Studies

Historical control data on developmental toxicity studies in rodents

2014 ◽  
Vol 54 (3) ◽  
pp. 150-161 ◽  
Author(s):  
Makoto Ema ◽  
Katsumi Endoh ◽  
Ryou Fukushima ◽  
Sakiko Fujii ◽  
Hiroaki Hara ◽  
...  
Keyword(s):  
Developmental Toxicity ◽  
Historical Control ◽  
Control Data ◽  
Toxicity Studies ◽  
Historical Control Data
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