scholarly journals P16‐89: Comparison of clinical features between the high and low serum KL‐6 patients with acute exacerbation of interstitial lung diseases

Respirology ◽  
2021 ◽  
Vol 26 (S3) ◽  
pp. 485-487
Keyword(s):  
Acute Exacerbation ◽  
Clinical Features ◽  
Lung Diseases ◽  
Interstitial Lung Diseases ◽  
Low Serum

scholarly journals Comparison of Clinical Features between the High and Low Serum KL-6 Patients with Acute Exacerbation of Interstitial Lung Diseases

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Yoichi Tagami ◽  
Yu Hara ◽  
Kota Murohashi ◽  
Ryo Nagasawa ◽  
Yurika Nishikawa ◽  
...  
Keyword(s):  
Acute Exacerbation ◽  
Clinical Features ◽  
Lung Diseases ◽  
Serum Lactate ◽  
Interstitial Lung Diseases ◽  
High Serum ◽  
Charlson Comorbidity Index Score ◽  
Serum Lactate Dehydrogenase ◽  
Significant Difference ◽  
Low Serum

Background. Serum Krebs von den Lungen-6 (KL-6) measurement is widely used to assess disease activity or prognosis in patients with interstitial lung diseases (ILDs). However, the clinical differences between high and low serum KL-6 levels at the time of acute exacerbation (AE) of ILD are not well known. Methods. Clinical parameters including age, sex, Charlson Comorbidity Index score (CCIS), blood biomarkers, high-resolution CT findings, and disease mortality were retrospectively compared between high and low KL-6 (cutoff value: 1000 U/mL) patients at the time of diagnosis of AE of ILDs. Results. Thirty-eight high serum KL-6 and 57 low serum KL-6 patients were included. There was no significant difference in 6-month mortality between them ( P  = 0.685), whereas serum lactate dehydrogenase was a significant predictor of 6-month mortality in the high serum KL-6 patients (odds ratio (OR): 1.006; 95% confidence interval (CI): 1.003–1.009; P  < 0.001), and CCIS (OR: 1.502; 95% CI: 1.242–1.838; P  < 0.001) and sex (OR: 5.751; 95% CI: 1.121–105.163; P  = 0.033) were significant predictors in low serum KL-6 patients. In addition, the incidences of congestive heart failure, symptomatic chronic pulmonary disease, cerebrovascular disease, and second metastatic solid tumours were significantly higher in nonsurvivors with low serum KL-6 than in other groups ( P  < 0.05). Conclusions. The clinical features in patients with AEs of ILDs may differ depending on the serum KL-6 level, and clinicopathological examination according to this subtyping guided by the serum KL-6 level is essential.

scholarly journals Clinical significance of respiratory virus detection in patients with acute exacerbation of interstitial lung diseases

2018 ◽  
Vol 136 ◽  
pp. 88-92 ◽  
Author(s):  
Takeshi Saraya ◽  
Hirokazu Kimura ◽  
Daisuke Kurai ◽  
Masaki Tamura ◽  
Yukari Ogawa ◽  
...  
Keyword(s):  
Acute Exacerbation ◽  
Clinical Significance ◽  
Lung Diseases ◽  
Respiratory Virus ◽  
Virus Detection ◽  
Interstitial Lung Diseases

scholarly journals Clinical Features of Interstitial Lung Diseases

1996 ◽  
Vol 11 (2) ◽  
pp. 113-121 ◽  
Author(s):  
Gune Il Lim ◽  
Kwang Hee Lee ◽  
Seong Whan Jeong ◽  
Soo Taek Uh ◽  
So Young Jin ◽  
...  
Keyword(s):  
Clinical Features ◽  
Lung Diseases ◽  
Interstitial Lung Diseases

Acute exacerbation admissions of fibrosing interstitial lung diseases – 3 years study

2019 ◽  
Author(s):  
Sónia Isabel Silva Guerra ◽  
Mariana Conceição ◽  
Ângela Cunha ◽  
Joana Correia ◽  
Jorge Vale ◽  
...  
Keyword(s):  
Acute Exacerbation ◽  
Lung Diseases ◽  
Interstitial Lung Diseases

scholarly journals Three cases of sequential treatment with nintedanib following pulsed-dose corticosteroids for acute exacerbation of interstitial lung diseases

2021 ◽  
Vol 33 ◽  
pp. 101385
Author(s):  
Kazuki Nakashima ◽  
Toyoshi Yanagihara ◽  
Sae Ishida ◽  
Naruhiko Ogo ◽  
Ayaka Egashira ◽  
...  
Keyword(s):  
Acute Exacerbation ◽  
Lung Diseases ◽  
Interstitial Lung Diseases ◽  
Sequential Treatment

scholarly journals Clinical subtyping for patients with acute exacerbations of interstitial lung diseases guided by serum KL-6 measurement

2021 ◽  
Author(s):  
Yoichi Tagami ◽  
Yu Hara ◽  
Kota Murohashi ◽  
Ryo Nagasawa ◽  
Yurika Nishikawa ◽  
...  
Keyword(s):  
Lung Diseases ◽  
Serum Lactate ◽  
Interstitial Lung Diseases ◽  
High Serum ◽  
Charlson Comorbidity Index Score ◽  
Serum Lactate Dehydrogenase ◽  
Disease Mortality ◽  
Significant Difference ◽  
Acute Exacerbations ◽  
Low Serum

Abstract Introduction: Serum Krebs von den Lungen-6 (KL-6) measurement is widely used to assess disease activity or prognosis in patients with interstitial lung diseases (ILDs). However, the clinical differences between high and low serum KL-6 levels at the time of acute exacerbation (AE) of ILD are not well known.Methods: Clinical parameters including age, sex, Charlson Comorbidity Index score (CCIS), blood biomarkers, high-resolution CT findings, and disease mortality were retrospectively compared between high and low KL-6 (cut-off value: 1000 U/mL) patients at the time of diagnosis of AE of ILDs.Results: 38 high serum KL-6 and 57 low serum KL-6 patients were included. There was no significant difference in 6-month mortality between them (P = 0.685). Whereas serum lactate dehydrogenase was a significant predictor of 6-month mortality in the high serum KL-6 patients (odds ratio (OR), 1.006; 95% confidence interval (CI), 1.003-1.009; P < 0.001), CCIS (OR, 1.502; 95% CI, 1.242-1.838; P < 0.001) and sex (OR, 5.751; 95% CI, 1.121-105.163; P = 0.033) were significant predictors in low serum KL-6 patients. In addition, the incidences of congestive heart failure, symptomatic chronic pulmonary disease, cerebrovascular disease, and second metastatic solid tumours were significantly higher in non-survivors with low serum KL-6 than in other groups (p < 0.05).Conclusions: The clinical features in patients with AEs of ILDs may differ depending on the serum KL-6 level, and clinicopathological examination according to this subtyping guided by the serum KL-6 level is essential.

scholarly journals Exacerbation of bleomycin-induced injury by lipopolysaccharide in mice: establishment of a mouse model for acute exacerbation of interstitial lung diseases

2015 ◽  
Vol 48 (4) ◽  
pp. e85-e91 ◽  
Author(s):  
Toru Kimura ◽  
Takashi Nojiri ◽  
Hiroshi Hosoda ◽  
Yasushi Shintani ◽  
Masayoshi Inoue ◽  
...  
Keyword(s):  
Mouse Model ◽  
Acute Exacerbation ◽  
Lung Diseases ◽  
Interstitial Lung Diseases
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