scholarly journals P16‐46: Sarcoid‐like reaction in patients with malignant solid‐tumor: long term clinical course and outcome

Respirology ◽  
2021 ◽  
Vol 26 (S3) ◽  
pp. 467-468
Keyword(s):  
Solid Tumor ◽  
Clinical Course ◽  
Malignant Solid Tumor

Physical and psychological outcome in long-term survivors of childhood malignant solid tumor in Japan

2011 ◽  
Vol 27 (7) ◽  
pp. 713-720 ◽  
Author(s):  
Nami Honda ◽  
Shunichi Funakoshi ◽  
Hideo Ambo ◽  
Masaki Nio ◽  
Yutaka Hayashi ◽  
...  
Keyword(s):  
Solid Tumor ◽  
Psychological Outcome ◽  
Malignant Solid Tumor ◽  
Long Term Survivors

scholarly journals Severe tricuspid regurgitation 14 years after diagnosis of “transient neonatal tricuspid regurgitation”

Heart ◽  
2001 ◽  
Vol 86 (1) ◽  
pp. 88-90
Author(s):  
D Boshoff ◽  
L Mertens ◽  
M Gewillig
Keyword(s):  
Tricuspid Regurgitation ◽  
Neonatal Period ◽  
Clinical Course ◽  
Subsequent Evolution ◽  
Severe Tricuspid Regurgitation ◽  
Echocardiographic Examination ◽  
Long Term Follow Up ◽  
Transient Tricuspid Regurgitation

A 14 year old girl presented with severe tricuspid regurgitation after she was diagnosed with “transient tricuspid regurgitation of the newborn”. In the neonatal period she had presented with severe tricuspid regurgitation without an obvious underlying anatomical cause. This spontaneously regressed during the first months of life. She was dismissed from follow up at the age of 5 years after complete normalisation of the clinical and echocardiographic examination. The subsequent evolution and management of the patient, as well as the possible pathogenesis responsible for the unusual clinical course, is discussed. This case stresses the importance of long term follow up of patients with transient tricuspid regurgitation.

Mild gray matter atrophy in patients with long-standing multiple sclerosis and favorable clinical course

2021 ◽  
pp. 135245852110196
Author(s):  
Rosa Cortese ◽  
Marco Battaglini ◽  
Francesca Parodi ◽  
Maria Laura Stromillo ◽  
Emilio Portaccio ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Multiple Sclerosis ◽  
Gray Matter ◽  
Clinical Course ◽  
Resonance Imaging ◽  
Volume Changes ◽  
Magnetic Resonance Imaging Mri ◽  
Global Brain ◽  
Diffuse Brain

The mechanisms responsible for the favorable clinical course in multiple sclerosis (MS) remain unclear. In this longitudinal study, we assessed whether magnetic resonance imaging (MRI)-based changes in focal and diffuse brain damage are associated with a long-term favorable MS diseases course. We found that global brain and gray matter (GM) atrophy changes were milder in MS patients with long-standing disease (⩾30 years from onset) and favorable (no/minimal disability) clinical course than in sex-age-matched disable MS patients, independently of lesions accumulation. Data showed that different trajectories of volume changes, as reflected by mild GM atrophy, may characterize patients with long-term favorable evolution.

Defining the Long-Term Clinical Course and Need for Repeat Dilation for Patients with Schatzki Rings

2021 ◽  
Author(s):  
Amrit K. Kamboj ◽  
Saam Dilmaghani ◽  
Beth A. Schueler ◽  
John M. Barlow ◽  
David A. Katzka
Keyword(s):  
Clinical Course

scholarly journals Rapid Escape from Preserved Cross-Reactive Neutralizing Humoral Immunity without Loss of Viral Fitness in HIV-1-Infected Progressors and Long-Term Nonprogressors

2010 ◽  
Vol 84 (7) ◽  
pp. 3576-3585 ◽  
Author(s):  
Marit J. van Gils ◽  
Evelien M. Bunnik ◽  
Judith A. Burger ◽  
Yodit Jacob ◽  
Becky Schweighardt ◽  
...  
Keyword(s):  
Humoral Immunity ◽  
Clinical Course ◽  
Viral Envelope ◽  
Viral Fitness ◽  
Viral Escape ◽  
Autologous Serum ◽  
Variable Regions ◽  
Neutralizing Activity ◽  
Hiv 1

ABSTRACT A substantial proportion of human immunodeficiency virus type 1 (HIV-1)-infected individuals has cross-reactive neutralizing activity in serum, with a similar prevalence in progressors and long-term nonprogressors (LTNP). We studied whether disease progression in the face of cross-reactive neutralizing serum activity is due to fading neutralizing humoral immunity over time or to viral escape. In three LTNP and three progressors, high-titer cross-reactive HIV-1-specific neutralizing activity in serum against a multiclade pseudovirus panel was preserved during the entire clinical course of infection, even after AIDS diagnosis in progressors. However, while early HIV-1 variants from all six individuals could be neutralized by autologous serum, the autologous neutralizing activity declined during chronic infection. This could be attributed to viral escape and the apparent inability of the host to elicit neutralizing antibodies to the newly emerging viral escape variants. Escape from autologous neutralizing activity was not associated with a reduction in the viral replication rate in vitro. Escape from autologous serum with cross-reactive neutralizing activity coincided with an increase in the length of the variable loops and in the number of potential N-linked glycosylation sites in the viral envelope. Positive selection pressure was observed in the variable regions in envelope, suggesting that, at least in these individuals, these regions are targeted by humoral immunity with cross-reactive potential. Our results may imply that the ability of HIV-1 to rapidly escape cross-reactive autologous neutralizing antibody responses without the loss of viral fitness is the underlying explanation for the absent effect of potent cross-reactive neutralizing humoral immunity on the clinical course of infection.

Genotype and Long-term Clinical Course of Bietti Crystalline Dystrophy in Korean and Japanese Patients

2021 ◽  
Author(s):  
Yusuke Murakami ◽  
Yoshito Koyanagi ◽  
Masatoshi Fukushima ◽  
Marika Yoshimura ◽  
Kohta Fujiwara ◽  
...  
Keyword(s):  
Clinical Course ◽  
Japanese Patients ◽  
Bietti Crystalline Dystrophy

Long-term clinical course of immunotactoid glomerulopathy complicated with diffuse large B-cell lymphoma

2021 ◽  
Author(s):  
Haruka Takahashi ◽  
Takashi Sano ◽  
Sayumi Kawamura ◽  
Keiko Sano ◽  
Ryoma Miyasaka ◽  
...  
Keyword(s):  
B Cell ◽  
Clinical Course ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Large B Cell Lymphoma ◽  
Immunotactoid Glomerulopathy ◽  
Large B Cell
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