scholarly journals P11‐15: Use of intravenous immunoglobulin in Streptococcus dysgalactiae associated toxic shock syndrome

Respirology ◽  
2021 ◽  
Vol 26 (S3) ◽  
pp. 413-414
Keyword(s):  
Intravenous Immunoglobulin ◽  
Toxic Shock Syndrome ◽  
Streptococcus Dysgalactiae ◽  
Toxic Shock

scholarly journals Refractory Toxic Shock-Like Syndrome fromStreptococcus dysgalactiaessp.equisimilisand Intravenous Immunoglobulin as Salvage Therapy: A Case Series

2016 ◽  
Vol 2016 ◽  
pp. 1-3
Author(s):  
Marjan Islam ◽  
Dennis Karter ◽  
Jerry Altshuler ◽  
Diana Altshuler ◽  
David Schwartz ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Intravenous Immunoglobulin ◽  
Salvage Therapy ◽  
Adjunctive Therapy ◽  
Case Series ◽  
Ivig Therapy ◽  
Mortality Rates ◽  
Invasive Disease ◽  
Streptococcus Dysgalactiae ◽  
Toxic Shock

Infections fromStreptococcus dysgalactiaessp.equisimilis(SDSE) can cause a wide variety of infections, ranging from mild cellulitis to invasive disease, such as endocarditis and streptococcal toxic shock-like syndrome (TSLS). Despite prompt and appropriate antibiotics, mortality rates associated with shock have remained exceedingly high, prompting the need for adjunctive therapy. IVIG has been proposed as a possible adjunct, given its ability to neutralize a wide variety of superantigens and modulate a dysregulated inflammatory response. We present the first reported cases of successful IVIG therapy for reversing shock in the treatment of SDSE TSLS.

Adjunctive Treatment of Streptococcal Toxic Shock Syndrome Using Intravenous Immunoglobulin: Case Report and Review

1997 ◽  
Vol 102 (1) ◽  
pp. 111-112 ◽  
Author(s):  
Carlos M Perez ◽  
Bernard M Kubak ◽  
Henry G Cryer ◽  
Saleh Salehmugodam ◽  
Paul Vespa ◽  
...  
Keyword(s):  
Case Report ◽  
Intravenous Immunoglobulin ◽  
Toxic Shock Syndrome ◽  
Adjunctive Treatment ◽  
Streptococcal Toxic Shock Syndrome ◽  
Toxic Shock

Early intravenous immunoglobulin therapy for group A β-haemolytic streptococcal meningitis with toxic shock syndrome

2021 ◽  
Vol 14 (3) ◽  
pp. e238472
Author(s):  
Derick Adigbli ◽  
Valerie Rozen ◽  
Archie Darbar ◽  
Pierre Janin
Keyword(s):  
Supportive Care ◽  
Intravenous Immunoglobulin ◽  
Toxic Shock Syndrome ◽  
Immunoglobulin Therapy ◽  
High Dose ◽  
Streptococcal Toxic Shock Syndrome ◽  
Full Time ◽  
Toxic Shock ◽  
Intravenous Immunoglobulin Therapy ◽  
Group A

A woman in her forties was transferred to a Sydney (Australia)-based tertiary hospital, following presentation to a regional hospital with group A Streptococcus (GAS) otomastoiditis; complicated by meningitis, venous sinus thrombosis, haemorrhagic cerebral infarction and subdural empyema. She rapidly deteriorated with profound cardiovascular collapse. Despite initiation of high dose vasoactive therapy, she remained shocked and developed multiorgan dysfunction syndrome. Early intravenous immunoglobulin therapy (140 g in two doses) was initiated as an adjunct to antimicrobial, surgical and supportive care for refractory streptococcal toxic shock syndrome. Over the course of a twelve-day intensive care unit stay she made good progress with de-escalation of her vasoactive supportive care and reversal of her organ injuries. She was subsequently discharged to ward-based care. At her three-month follow-up appointment she had significantly reduced neurological deficit. Five months following her presentation to hospital she had returned to full-time work.

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