scholarly journals P10‐17: Idiopathic central alveolar hypoventilation without respiratory failure that required differentiation from obstructive sleep apnea

Respirology ◽  
2021 ◽  
Vol 26 (S3) ◽  
pp. 404-404
Keyword(s):  
Obstructive Sleep Apnea ◽  
Respiratory Failure ◽  
Sleep Apnea ◽  
Obstructive Sleep ◽  
Alveolar Hypoventilation

Sleep, Obstructive Sleep Apnea, and Chronic Alveolar Hypoventilation in Cystic Fibrosis: Role of Noninvasive Ventilation During Sleep

2020 ◽  
Vol 9 (3) ◽  
pp. 110-117
Author(s):  
Pamela Barletta ◽  
Maria Tupayachi Ortiz ◽  
Alexandre R. Abreu ◽  
Matthias Salathe ◽  
Alejandro D. Chediak
Keyword(s):  
Cystic Fibrosis ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Noninvasive Ventilation ◽  
Obstructive Sleep ◽  
Alveolar Hypoventilation

scholarly journals Pulmonary complications in trauma patients with obstructive sleep apnea undergoing pelvic or lower limb operation

2020 ◽  
Vol 5 (1) ◽  
pp. e000529
Author(s):  
Michele Fiorentino ◽  
Franchesca Hwang ◽  
Sri Ram Pentakota ◽  
David H Livingston ◽  
Anne C Mosenthal
Keyword(s):  
Obstructive Sleep Apnea ◽  
Logistic Regression ◽  
Respiratory Failure ◽  
Sleep Apnea ◽  
Lower Limb ◽  
Independent Predictor ◽  
Ventilatory Support ◽  
Pulmonary Complications ◽  
Trauma Patients ◽  
Obstructive Sleep

BackgroundObstructive sleep apnea (OSA) is increasingly prevalent in the range of 2% to 24% in the US population. OSA is a well-described predictor of pulmonary complications after elective operation. Yet, data are lacking on its effect after operations for trauma. We hypothesized that OSA is an independent predictor of pulmonary complications in patients undergoing operations for traumatic pelvic/lower limb injuries (PLLI).MethodsNationwide Inpatient Sample (2009–2013) was queried for International Classification of Diseases, Ninth Revision, Clinical Modification codes for PLLI requiring operation. Elective admissions and those with concurrent traumatic brain injury with moderate to prolonged loss of consciousness were excluded. Outcome measures were pulmonary complications including ventilatory support, ventilator-associated pneumonia, pulmonary embolism (PE), acute respiratory distress syndrome (ARDS), and respiratory failure. Multivariable logistic regression analysis was used, adjusting for OSA, age, sex, race/ethnicity, and specific comorbidities (obesity, chronic lung disease, and pulmonary circulatory disease). P<0.01 was considered statistically significant.ResultsAmong the 337 333 patients undergoing PLLI operation 3.0% had diagnosed OSA. Patients with OSA had more comorbidities and were more frequently discharged to facilities. Median length of stay was longer in the OSA group (5 vs 4 days, p<0.001). Pulmonary complications were more frequent in those with OSA. Multivariable logistic regression showed that OSA was an independent predictor of ventilatory support (adjusted odds ratio (aOR), 1.37; 95% CI,1.24 to 1.51), PE (aOR 1.40; 95% CI, 1.15 to 1.70), ARDS (aOR 1.36; 95% CI,1.23 to 1.52), and respiratory failure (aOR 1.90; 95% CI, 1.74 to 2.06).ConclusionOSA is an independent and underappreciated predictor of pulmonary complications in those undergoing emergency surgery for PLLI. More aggressive screening and identification of OSA in trauma patients undergoing operation are necessary to provide closer perioperative monitoring and interventions to reduce pulmonary complications and improve outcomes.Level of evidencePrognostic Level IV.

scholarly journals 1236 A Case of Systemic Amyloidosis and Sleep-Related Hypoventilation

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A471-A472
Author(s):  
Lauren M Castner ◽  
Mark D Garwood
Keyword(s):  
Obstructive Sleep Apnea ◽  
Respiratory Failure ◽  
Sleep Apnea ◽  
Systemic Disease ◽  
Central Sleep Apnea ◽  
Systemic Amyloidosis ◽  
Rapid Progression ◽  
Bilevel Positive Airway Pressure ◽  
Obstructive Sleep ◽  
History Of

Abstract Introduction Amyloidoses are a group of systemic diseases characterized by misfolded protein fragment deposition within the organs, including the heart, kidney, liver, gastrointestinal tract, nervous system, pulmonary system, and soft tissues1. Obstructive and central sleep apnea are known to occur frequently in those with cardiac amyloidosis. This case discusses a patient with systemic amyloidosis and chronic hypercarbic, hypoxic respiratory failure. Report of Case A 66 year old female with a history of systemic amyloidosis, non-ischemic cardiomyopathy, hypertension, and obstructive sleep apnea was admitted for acute on chronic heart failure. Despite intravenous diuresis, she remained hypoxemic, requiring 1 liter per minute of oxygen. She was found to have bilaterally reduced diaphragmatic excursion and a restrictive ventilatory defect on spirometry. She had a preceding history of chronic carbon dioxide retention with elevated CO2 levels for greater than a year (52-74 mmHg). Sleep medicine was consulted to assist in evaluation of the patient’s obstructive sleep apnea and hypoxic, hypercarbic respiratory failure. Baseline polysomnogram revealed sleep related hypoventilation with transcutaneous CO2 (TCO2) ranging between 77-86 mmHg without clear obstructive sleep apnea. A bilevel positive airway pressure (BPAP) titration was then performed (TCO2 54-69 mmHg) and while the patient’s obstructive sleep apnea was well treated, sleep-related hypoventilation and central apneas persisted. Average volume assured pressure support (AVAPS) was initiated for management of sleep related hypoventilation. In follow up, the patient is feeling well, off oxygen, with daytime TCO2 38 mmHg. Conclusion This case demonstrates a rare complication of systemic amyloidosis in the setting of respiratory failure attributed to amyloid infiltration of the diaphragm. In the few previously reported cases of neuromuscular respiratory failure in systemic amyloidosis there is rapid progression and high mortality3, which highlights the importance of assessing for sleep disordered breathing and additional causes of respiratory failure in a patient with a complex systemic disease.

scholarly journals Benzodiazepines Associated With Acute Respiratory Failure in Patients With Obstructive Sleep Apnea

2019 ◽  
Vol 9 ◽  
Author(s):  
Sheng-Huei Wang ◽  
Wei-Shan Chen ◽  
Shih-En Tang ◽  
Hung-Che Lin ◽  
Chung-Kan Peng ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Respiratory Failure ◽  
Sleep Apnea ◽  
Acute Respiratory Failure ◽  
Obstructive Sleep

scholarly journals Obstructive sleep apnea in patients surviving acute hypercapnic respiratory failure is best predicted by static hyperinflation

PLoS ONE ◽  
2018 ◽  
Vol 13 (10) ◽  
pp. e0205669 ◽  
Author(s):  
Dan Adler ◽  
Elise Dupuis-Lozeron ◽  
Jean Paul Janssens ◽  
Paola M. Soccal ◽  
Frédéric Lador ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Respiratory Failure ◽  
Sleep Apnea ◽  
Hypercapnic Respiratory Failure ◽  
Obstructive Sleep ◽  
Acute Hypercapnic Respiratory Failure

scholarly journals Obstructive sleep apnea and risk of COVID-19 infection, hospitalization and respiratory failure

2021 ◽  
Author(s):  
M. D. de Kruif ◽  
S. F. J. Voncken ◽  
S. A. J. S. Laven ◽  
T. M. H. Feron ◽  
A. A. B. Kolfoort-Otte
Keyword(s):  
Obstructive Sleep Apnea ◽  
Respiratory Failure ◽  
Sleep Apnea ◽  
Obstructive Sleep
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