scholarly journals P8‐156: A case of thymic cancer treated with chemotherapy of S‐1

Respirology ◽  
2021 ◽  
Vol 26 (S3) ◽  
pp. 349-349
Keyword(s):  
Thymic Cancer

scholarly journals Emergence of Myasthenia Gravis with Myositis in a Patient Treated with Pembrolizumab for Thymic Cancer

2018 ◽  
Vol 14 (1) ◽  
pp. 115 ◽  
Author(s):  
So-Young Huh ◽  
Seong-Hoon Shin ◽  
Meyung Kug Kim ◽  
So-Young Lee ◽  
Ki Hun Son ◽  
...  
Keyword(s):  
Myasthenia Gravis ◽  
Thymic Cancer

Clinical Utility of Striational Antibodies in Paraneoplastic and Myasthenia Gravis Paraneoplastic Panels

Neurology ◽  
2021 ◽  
pp. 10.1212/WNL.0000000000012050
Author(s):  
Shahar Shelly ◽  
John R Mills ◽  
Divyansu Dubey ◽  
Andrew McKeon ◽  
Anastasia Zekeridou ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Myasthenia Gravis ◽  
Clinical Utility ◽  
Roc Analysis ◽  
Thymic Cancer ◽  
Diagnostic Characteristics ◽  
Data Platform ◽  
Neurological Phenotype ◽  
Antibody Positivity

Objective:To critically assess the clinical utility of striational antibodies (StrAbs) within paraneoplastic and myasthenia gravis serological evaluations.Methods:All Mayo Clinic patients tested for StrAbs from January 1st 2012-December 31st 2018 utilizing Mayo’s Unified Data Platform (UDP) were reviewed for neurological diagnosis and cancer.Results:38,502 unique paraneoplastic and 1,899 MG patients were tested. In paraneoplastic evaluations, the StrAbs positivity rate was higher in cancer vs without cancer (5% [321/6775] vs 4% [1154/31727]; p<0.0001; OR 1.35; CI=1.19-1.53) but ROC analysis indicated no diagnostic accuracy in cancer (AUC=0.505). No neurological phenotype was significantly associated with StrAbs in the paraneoplastic group. Positivity was more common in all MG cancers compared to paraneoplastic cancers (p<0.0001). In MG evaluations, the StrAbs positivity rate was higher in those with cancer vs without (46% [217/474] vs 26% [372/1425]; p<0.0001; OR 2.39, CI 1.9-2.96) with ROC analysis indicating poor diagnostic accuracy for thymic cancer (AUC 0.634, recommended cutoff=1:60, sensitivity=56%, specificity=71%), with worse accuracy for extrathymic cancers (AUC 0.543). In paraneoplastic or MG evaluations, the value of antibody positivity did not improve cancer predictions. Paraneoplastic evaluated patients were more likely with positive StrAbs to obtain computed tomography (CT) (p=0.0001) with 3% (12/468) cancer found.Conclusion:Despite a statistically significant association with cancer, an expansive review of performance in clinical service demonstrates that StrAbs are neither specific nor sensitive in predicting malignancy or neurological phenotypes. CT imaging is over utilized with positive StrAbs results. Removal of StrAbs from paraneoplastic or MG evaluations will improve the diagnostic characteristics of the current MG test.Classification of Evidence:This study provides Class II evidence that the presence of StrAbs do not accurately identify patients with malignancy or neurological phenotypes.

scholarly journals Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Alejandro Álvarez-Quilón ◽  
José Terrón-Bautista ◽  
Irene Delgado-Sainz ◽  
Almudena Serrano-Benítez ◽  
Rocío Romero-Granados ◽  
...  
Keyword(s):  
Topoisomerase Ii ◽  
Cancer Predisposition ◽  
Dna Breaks ◽  
Thymic Cancer

scholarly journals Clinical study of eight cases of thymic cancer

2006 ◽  
Vol 20 (2) ◽  
pp. 121-125 ◽  
Author(s):  
Keitarou Matsumoto ◽  
Tsutomu Tagawa ◽  
Akihiro Nakamura ◽  
Naoya Yamasaki ◽  
Tomoyuki Shirafuji ◽  
...  
Keyword(s):  
Clinical Study ◽  
Thymic Cancer

scholarly journals A case of thymic cancer with spontaneous regression detected on examination for thoracic injury

2015 ◽  
Vol 29 (5) ◽  
pp. 605-609 ◽  
Author(s):  
Toshiya Fujiwara ◽  
Kouta Araki ◽  
Hitoshi Nishikawa ◽  
Kazutoshi Kotani ◽  
Motoki Matsuura
Keyword(s):  
Spontaneous Regression ◽  
Thoracic Injury ◽  
Thymic Cancer

Limbic encephalitis associated with thymic cancer: a case report

2001 ◽  
Vol 248 (11) ◽  
pp. 1000-1002 ◽  
Author(s):  
Carla D'Avino ◽  
Marco Lucchi ◽  
Roberto Ceravolo ◽  
Alfredo Mussi ◽  
Alessandro Malandrini ◽  
...  
Keyword(s):  
Case Report ◽  
Limbic Encephalitis ◽  
Thymic Cancer

scholarly journals S2157 A Rare Cause of Dysphagia: Polypoidal Esophageal Masses From Poorly Differentiated Thymic Cancer

2021 ◽  
Vol 116 (1) ◽  
pp. S926-S927
Author(s):  
Harleen K. Chela ◽  
Mary Mikhael ◽  
Omer Basar ◽  
Feng Yin ◽  
Veysel Tahan ◽  
...  
Keyword(s):  
Thymic Cancer ◽  
Poorly Differentiated
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