scholarly journals P1‐56: A case of pulmonary alveolar proteinosis with severe respiratory failure improved by segmental lung lavage with fiberoptic bronchoscopy under general anesthesia

Respirology ◽  
2021 ◽  
Vol 26 (S3) ◽  
pp. 95-95
Keyword(s):  
Respiratory Failure ◽  
General Anesthesia ◽  
Pulmonary Alveolar Proteinosis ◽  
Fiberoptic Bronchoscopy ◽  
Lung Lavage ◽  
Severe Respiratory Failure ◽  
Alveolar Proteinosis

scholarly journals Lobar flexible fiberoptic lung lavage: therapeutic benefit in severe respiratory failure in pulmonary alveolar proteinosis and influenza A H1N1 pneumonia

2011 ◽  
Vol 1 (3) ◽  
pp. 53 ◽  
Author(s):  
Antonello Nicolini ◽  
Cornelius Barlascini
Keyword(s):  
Respiratory Failure ◽  
Influenza A ◽  
Pulmonary Alveolar Proteinosis ◽  
Therapeutic Benefit ◽  
Lung Lavage ◽  
Safe Procedure ◽  
Severe Respiratory Failure ◽  
Influenza A H1n1 ◽  
Virus Pneumonia ◽  
Alveolar Proteinosis

Lobar fiberoptic lung lavage is a well-known procedure used in primary pulmonary alveolar proteinosis (PAP); the use of this procedure has increased in the recent years. This procedure has also been used in other pulmonary diseases such as desquamative interstitial pneumonia with good results. We describe a case of extremely severe respiratory failure due to concurrence of PAP and Influenza A H1N1 virus pneumonia which resolved with the help of this procedure. The patient, a 41- year-old woman, needed less mechanical ventilation after undergoing lobar fiberoptic bronchoscopic lavage. Moreover, a rapid and progressive improvement in the computed tomography of the lungs was observed. Flexibile fiberoptic bronchoscopic lobar lavage is a simple, safe procedure used not only in milder disease, but also in particular severe cases in which the physiological derangement of whole lung lavage would not be tolerated by patient or when extra-corporeal membrane oxygenation is not available.

scholarly journals Rare Presentation of Pulmonary Alveolar Proteinosis Causing Acute Respiratory Failure

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Ryan R. Kroll ◽  
Sameer Kumar ◽  
Ronald F. Grossman ◽  
Charles Price ◽  
John R. Srigley
Keyword(s):  
Respiratory Failure ◽  
Pulmonary Alveolar Proteinosis ◽  
Periodic Acid ◽  
Rare Condition ◽  
Lung Lavage ◽  
Hypoxemic Respiratory Failure ◽  
Rare Presentation ◽  
Periodic Acid Schiff ◽  
Novel Treatments ◽  
Alveolar Proteinosis

Pulmonary alveolar proteinosis (PAP) is a rare condition characterized by dysfunctional alveolar macrophages, which ineffectively clear surfactant and typically cause mild hypoxemia. Characteristic Computed Tomography findings are septal reticulations superimposed on ground-glass opacities in a crazy paving pattern, with a clear juxtaposition between affected and unaffected parenchyma. While traditionally PAP was diagnosed via biopsy, bronchoalveolar lavage (BAL) is usually sufficient; the fluid appears milky, and on microscopic examination there are foamy macrophages with eosinophilic granules and extracellular hyaline material that is Periodic Acid-Schiff positive. Standard therapy is whole lung lavage (WLL), although novel treatments are under development. The case presented is a 55-year-old woman with six months of progressive dyspnea, who developed hypoxemic respiratory failure requiring mechanical ventilation; she had typical findings of PAP on imaging and BAL. WLL was ultimately successful in restoring adequate oxygenation. Respiratory failure of this magnitude is a rare finding in PAP.

How to do whole lung lavage for treatment of pulmonary alveolar proteinosis

2020 ◽  
Vol 90 (5) ◽  
pp. 877-878
Author(s):  
Tovi Vo ◽  
Justin C. Y. Chan ◽  
Michael Worthington
Keyword(s):  
Pulmonary Alveolar Proteinosis ◽  
Lung Lavage ◽  
Whole Lung Lavage ◽  
Alveolar Proteinosis

scholarly journals The Clinical Clues of Pulmonary Alveolar Proteinosis: A Report of 11 Cases and Literature Review

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Qiongya Mo ◽  
Bingbin Wang ◽  
Nian Dong ◽  
Lianmin Bao ◽  
Xiaoqiong Su ◽  
...  
Keyword(s):  
Bronchoalveolar Lavage Fluid ◽  
Clinical Symptoms ◽  
Pulmonary Alveolar Proteinosis ◽  
Relevant Literature ◽  
Neuron Specific Enolase ◽  
Lavage Fluid ◽  
Lung Lavage ◽  
Serum Markers ◽  
Open Lung Biopsy ◽  
Alveolar Proteinosis

Pulmonary alveolar proteinosis (PAP) is a rare interstitial lung disease characterized by the abnormal alveolar accumulation of surfactant components. The diagnosis of PAP can be easily missed since it is rare and lacks specific clinical symptoms. It is of great importance to have a better understanding of the crucial clue to clinically diagnose PAP and take PAP into consideration in the differential diagnosis of interstitial pulmonary diseases or other diseases with similar manifestations. Here, we analyze the clinical characteristics of 11 cases of PAP patients in local hospital and review the relevant literature in order to provide more information in diagnosis and management of PAP. In our observation, cyfra21-1 and neuron-specific enolase (NSE) known as tumor markers probably can be useful serum markers for diagnosis of PAP. As for the method of pathologic diagnosis, open-lung biopsy was the gold standard but now it is less required because findings on examination of bronchoalveolar lavage fluid (BALF) can help to make the diagnosis. We also have deep experience about when and how to carry out lung lavage.

scholarly journals Pulmonary alveolar proteinosis treatment by whole-lung lavage

2012 ◽  
Vol 88 (1042) ◽  
pp. 492-493 ◽  
Author(s):  
Chang Cai ◽  
Min Ye ◽  
Honglei Xu ◽  
Yuping Li
Keyword(s):  
Pulmonary Alveolar Proteinosis ◽  
Lung Lavage ◽  
Whole Lung Lavage ◽  
Alveolar Proteinosis
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