scholarly journals P8‐10: Minichromosome maintenance complex component (MCM) genes in lung adenocarcinoma: MCM‐family acts as a potential therapeutic target

Respirology ◽  
2021 ◽  
Vol 26 (S3) ◽  
pp. 291-291
Keyword(s):  
Lung Adenocarcinoma ◽  
Therapeutic Target ◽  
Minichromosome Maintenance ◽  
Potential Therapeutic Target ◽  
Complex Component

Abstract 4053: Mucin 5ac as a potential therapeutic target for KRAS-driven lung adenocarcinoma

2020 ◽  
Author(s):  
Walter V. Velasco Torrez ◽  
Shanshan Deng ◽  
Marco A. Ramos-Castaneda ◽  
Segundo W. Del Aguila-Soto ◽  
Seyed Moghaddam
Keyword(s):  
Lung Adenocarcinoma ◽  
Therapeutic Target ◽  
Potential Therapeutic Target

scholarly journals RNA-Seq Analysis Identified XLOC_009190 as Potential Therapeutic Target for Lung Adenocarcinoma

2019 ◽  
Vol Volume 12 ◽  
pp. 11221-11229
Author(s):  
Jing Wang ◽  
Ning Wang ◽  
Wei-dong Zhao ◽  
Li-xian Zhao ◽  
Yong-guang Jing ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Therapeutic Target ◽  
Rna Seq ◽  
Potential Therapeutic Target

scholarly journals CRKL mediates EML4-ALK signaling and is a potential therapeutic target for ALK-rearranged lung adenocarcinoma

Oncotarget ◽  
2016 ◽  
Vol 7 (20) ◽  
pp. 29199-29210 ◽  
Author(s):  
Rong An ◽  
Yisong Wang ◽  
Donna Voeller ◽  
Arjan Gower ◽  
In-Kyu Kim ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Therapeutic Target ◽  
Potential Therapeutic Target

scholarly journals Maternal embryonic leucine zipper kinase: A novel biomarker and a potential therapeutic target in lung adenocarcinoma

2020 ◽  
Vol 20 (5) ◽  
pp. 1-1
Author(s):  
Shengsong Chen ◽  
Zhanpeng Lu ◽  
Xiaoyong Chen ◽  
Xiya Wu ◽  
Hongying Tu ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Therapeutic Target ◽  
Leucine Zipper ◽  
Potential Therapeutic Target ◽  
Kinase A

scholarly journals CYP4B1 is a prognostic biomarker and potential therapeutic target in lung adenocarcinoma

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0247020
Author(s):  
Xiaoling Liu ◽  
Yichen Jia ◽  
Changyuan Shi ◽  
Dechen Kong ◽  
Yuanming Wu ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Therapeutic Target ◽  
Prognostic Biomarker ◽  
Secondary Analysis ◽  
Enrichment Analysis ◽  
Gene Set Enrichment Analysis ◽  
The Cancer Genome Atlas ◽  
Potential Therapeutic Target ◽  
Wide Range ◽  
Endogenous Compounds

CYP4B1 belongs to the mammalian CYP4 enzyme family and is predominantly expressed in the lungs of humans. It is responsible for the oxidative metabolism of a wide range of endogenous compounds and xenobiotics. In this study, using data from The Cancer Genome Atlas (TCGA) project and the Gene Expression Omnibus (GEO) database, a secondary analysis was performed to explore the expression profile of CYP4B1, as well as its prognostic value in patients with lung adenocarcinoma (LUAD). Based on the obtained results, a significantly decreased CYP4B1 expression was discovered in patients with LUAD when compared with their normal counterparts (p<0.05), and was linked to age younger than 65 years (p = 0.0041), history of pharmaceutical (p = 0.0127) and radiation (p = 0.0340) therapy, mutations in KRAS/EGFR/ALK (p = 0.0239), and living status of dead (p = 0.0026). Survival analysis indicated that the low CYP4B1 expression was an independent prognostic indicator of shorter survival in terms of overall survival (OS) and recurrence-free survival (RFS) in patients with LUAD. The copy number alterations (CNAs) and sites of cg23440155 and cg23414387 hypermethylation might contribute to the decreased CYP4B1 expression. Gene set enrichment analysis (GSEA) suggested that CYP4B1 might act as an oncogene in LUAD by preventing biological metabolism pathways of exogenous and endogenous compounds and enhancing DNA replication and cell cycle activities. In conclusion, CYP4B1 expression may serve as a valuable independent prognostic biomarker and a potential therapeutic target in patients with LUAD.

scholarly journals Matrix Metalloproteinase 11 Is a Potential Therapeutic Target in Lung Adenocarcinoma

2019 ◽  
Vol 14 ◽  
pp. 82-93 ◽  
Author(s):  
Haoran Yang ◽  
Peng Jiang ◽  
Dongyan Liu ◽  
Hong-Qiang Wang ◽  
Qingmei Deng ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Lung Adenocarcinoma ◽  
Therapeutic Target ◽  
Potential Therapeutic Target
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