Thoracoabdominal asynchrony associates with exercise intolerance in fibrotic interstitial lung diseases

Respirology ◽  
2021 ◽  
Author(s):  
Pauliane Vieira Santana ◽  
Leticia Zumpano Cardenas ◽  
Jeferson George Ferreira ◽  
Carlos Roberto Ribeiro Carvalho ◽  
André Luis Pereira Albuquerque ◽  
...  
Keyword(s):  
Lung Diseases ◽  
Interstitial Lung Diseases ◽  
Exercise Intolerance ◽  
Thoracoabdominal Asynchrony

scholarly journals Exercise-Based Pulmonary Rehabilitation for Interstitial Lung Diseases: A Review of Components, Prescription, Efficacy, and Safety

2021 ◽  
Vol 2 ◽  
Author(s):  
Renata G. Mendes ◽  
Viviane Castello-Simões ◽  
Renata Trimer ◽  
Adriana S. Garcia-Araújo ◽  
Andrea Lucia Gonçalves Da Silva ◽  
...  
Keyword(s):  
Exercise Training ◽  
Pulmonary Rehabilitation ◽  
Lung Diseases ◽  
Interstitial Lung Diseases ◽  
Exercise Intolerance ◽  
Muscle Dysfunction ◽  
Efficacy And Safety ◽  
Skeletal Muscle Dysfunction ◽  
Frequency Components

Interstitial lung diseases (ILDs) comprise a heterogeneous group of disorders (such as idiopathic pulmonary fibrosis, sarcoidosis, asbestosis, and pneumonitis) characterized by lung parenchymal impairment, inflammation, and fibrosis. The shortness of breath (i.e., dyspnea) is a hallmark and disabling symptom of ILDs. Patients with ILDs may also exhibit skeletal muscle dysfunction, oxygen desaturation, abnormal respiratory patterns, pulmonary hypertension, and decreased cardiac function, contributing to exercise intolerance and limitation of day-to-day activities. Pulmonary rehabilitation (PR) including physical exercise is an evidence-based approach to benefit functional capacity, dyspnea, and quality of life in ILD patients. However, despite recent advances and similarities with other lung diseases, the field of PR for patients with ILD requires further evidence. This mini-review aims to explore the exercise-based PR delivered around the world and evidence supporting prescription modes, considering type, intensity, and frequency components, as well as efficacy and safety of exercise training in ILDs. This review will be able to strengthen the rationale for exercise training recommendations as a core component of the PR for ILD patients.

Lung ultrasound in the evaluation of interstitial lung diseases

2016 ◽  
Vol 37 (S 01) ◽  
Author(s):  
N Buda ◽  
M Piskunowicz ◽  
M Porzezińska ◽  
W Kosiak ◽  
Z Zdrojewski
Keyword(s):  
Lung Diseases ◽  
Lung Ultrasound ◽  
Interstitial Lung Diseases

Characteristics of the immune and cytokine status in patients with interstitial lung diseases

2018 ◽  
Vol 1 (1) ◽  
pp. 25-29
Author(s):  
Mirgolib RAКHIMOV ◽  
◽  
Nematilla ARALOV ◽  
Shukhrat Ziyadullaev
Keyword(s):  
Lung Diseases ◽  
Interstitial Lung Diseases

Value of Thoracoscopic Lung Biopsy in Diagnosis of Diffuse Interstitial Lung Diseases

2018 ◽  
Vol 86 (6) ◽  
pp. 1159-1163
Author(s):  
ISMAEIL A. ATTIA, M.D.; MOHAMED S. AL-HAKIM, M.D. ◽  
KHALED M.I. HALIMA, M.D.; MOAZ A.E. ABD EL-ATI, M.Sc.
Keyword(s):  
Lung Biopsy ◽  
Lung Diseases ◽  
Interstitial Lung Diseases

scholarly journals Reply to Wand et al.: Role of Transbronchial Cryobiopsy in Interstitial Lung Diseases: An Ongoing Tale

2020 ◽  
Vol 201 (2) ◽  
pp. 260-261
Author(s):  
Arnaud Bourdin ◽  
Carey M. Suehs ◽  
Thomas V. Colby ◽  
Isabelle Vachier ◽  
Nicolas Molinari ◽  
...  
Keyword(s):  
Lung Diseases ◽  
Interstitial Lung Diseases

scholarly journals Cellular Senescence in Lung Fibrosis

2021 ◽  
Vol 22 (13) ◽  
pp. 7012
Author(s):  
Fernanda Hernandez-Gonzalez ◽  
Rosa Faner ◽  
Mauricio Rojas ◽  
Alvar Agustí ◽  
Manuel Serrano ◽  
...  
Keyword(s):  
Cell Fate ◽  
Cellular Senescence ◽  
Lung Fibrosis ◽  
Lung Diseases ◽  
Physiological Mechanism ◽  
Lung Parenchyma ◽  
Scar Tissue ◽  
Interstitial Lung Diseases ◽  
Cellular Damage ◽  
Age Related

Fibrosing interstitial lung diseases (ILDs) are chronic and ultimately fatal age-related lung diseases characterized by the progressive and irreversible accumulation of scar tissue in the lung parenchyma. Over the past years, significant progress has been made in our incomplete understanding of the pathobiology underlying fibrosing ILDs, in particular in relation to diverse age-related processes and cell perturbations that seem to lead to maladaptation to stress and susceptibility to lung fibrosis. Growing evidence suggests that a specific biological phenomenon known as cellular senescence plays an important role in the initiation and progression of pulmonary fibrosis. Cellular senescence is defined as a cell fate decision caused by the accumulation of unrepairable cellular damage and is characterized by an abundant pro-inflammatory and pro-fibrotic secretome. The senescence response has been widely recognized as a beneficial physiological mechanism during development and in tumour suppression. However, recent evidence strengthens the idea that it also drives degenerative processes such as lung fibrosis, most likely by promoting molecular and cellular changes in chronic fibrosing processes. Here, we review how cellular senescence may contribute to lung fibrosis pathobiology, and we highlight current and emerging therapeutic approaches to treat fibrosing ILDs by targeting cellular senescence.

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