scholarly journals Diagnosis and treatment of lung disease associated with alpha one‐antitrypsin deficiency: A position statement from the Thoracic Society of Australia and New Zealand*

Respirology ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 321-335
Author(s):  
Jack Dummer ◽  
Claudia C. Dobler ◽  
Mark Holmes ◽  
Daniel Chambers ◽  
Ian A. Yang ◽  
...  
Keyword(s):  
New Zealand ◽  
Lung Disease ◽  
Position Statement ◽  
Diagnosis And Treatment ◽  
Antitrypsin Deficiency

scholarly journals Respiratory management of infants with chronic neonatal lung disease beyond the NICU : A position statement from the Thoracic Society of Australia and New Zealand*

Respirology ◽  
2020 ◽  
Vol 25 (8) ◽  
pp. 880-888 ◽  
Author(s):  
Nitin Kapur ◽  
Gillian Nixon ◽  
Philip Robinson ◽  
John Massie ◽  
Bernadette Prentice ◽  
...  
Keyword(s):  
New Zealand ◽  
Lung Disease ◽  
Position Statement ◽  
Respiratory Management ◽  
Neonatal Lung ◽  
Chronic Neonatal Lung Disease

scholarly journals The interstitial lung disease multidisciplinary meeting: A position statement from the Thoracic Society of Australia and New Zealand and the Lung Foundation Australia

Respirology ◽  
2017 ◽  
Vol 22 (7) ◽  
pp. 1459-1472 ◽  
Author(s):  
Jyotika D. Prasad ◽  
Annabelle Mahar ◽  
Jane Bleasel ◽  
Samantha J. Ellis ◽  
Daniel C. Chambers ◽  
...  
Keyword(s):  
New Zealand ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Position Statement ◽  
Multidisciplinary Meeting

scholarly journals Management of lung disease in alpha-1 antitrypsin deficiency: what we do and what we do not know

2021 ◽  
Vol 12_suppl ◽  
pp. 204062232110101
Author(s):  
Igor Barjaktarevic ◽  
Michael Campos
Keyword(s):  
Lung Disease ◽  
Treatment Guidelines ◽  
Management Program ◽  
Lifestyle Changes ◽  
Chronic Obstructive ◽  
Augmentation Therapy ◽  
Lung Function Decline ◽  
Antitrypsin Deficiency ◽  
Alpha 1 Antitrypsin Deficiency ◽  
Alpha 1 Antitrypsin

Management of lung disease in patients with alpha-1 antitrypsin deficiency (AATD) includes both non-pharmacological and pharmacological approaches. Lifestyle changes with avoidance of environmental pollutants, including tobacco smoke, improving exercise levels and nutritional status, all encompassed under a disease management program, are crucial pillars of AATD management. Non-pharmacological therapies follow conventional treatment guidelines for chronic obstructive pulmonary disease. Specific pharmacological treatment consists of administering exogenous alpha-1 antitrypsin (AAT) protein intravenously (augmentation therapy). This intervention raises AAT levels in serum and lung epithelial lining fluid, increases anti-elastase capacity, and decreases several inflammatory mediators in the lung. Radiologically, augmentation therapy reduces lung density loss over time, thus delaying disease progression. The effect of augmentation therapy on other lung-related outcomes, such as exacerbation frequency/length, quality of life, lung function decline, and mortality, are less clear and questions regarding dose optimization or route of administration are still debatable. This review discusses the rationale and available evidence for these interventions in AATD.

scholarly journals Australia and New Zealand Transplant and Cellular Therapies COVID‐19 vaccination consensus position statement

2021 ◽  
Vol 51 (8) ◽  
pp. 1321-1323
Author(s):  
Nada Hamad ◽  
Michelle Ananda‐Rajah ◽  
Nicole Gilroy ◽  
Raina MacIntyre ◽  
David Gottlieb ◽  
...  
Keyword(s):  
New Zealand ◽  
Position Statement ◽  
Cellular Therapies

scholarly journals Molecular Basis of the Liver and Lung Disease Associated with the α1-Antitrypsin Deficiency Allele Mmalton

1989 ◽  
Vol 264 (23) ◽  
pp. 13938-13945
Author(s):  
D T Curiel ◽  
M D Holmes ◽  
H Okayama ◽  
M L Brantly ◽  
C Vogelmeier ◽  
...  
Keyword(s):  
Lung Disease ◽  
Molecular Basis ◽  
Antitrypsin Deficiency

Controversies in the Diagnosis and Treatment of Sickle Cell Lung Disease

2014 ◽  
Vol 15 (1) ◽  
pp. 3
Author(s):  
Manuel Arteta ◽  
Anastassios C. Koumbourlis
Keyword(s):  
Lung Disease ◽  
Sickle Cell ◽  
Diagnosis And Treatment
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