scholarly journals A CASE OF RECURRENT PULMONARY THROMBOEMBOLISM ASSOCIATED WITH METHYLENETETRAHYDROFOLATE REDUCTASE C677T POLYMORPHISM WITH NORMAL RANGE OF PLASMA HOMOCYSTEINE LEVEL

Respirology ◽  
2019 ◽  
Vol 24 (S2) ◽  
pp. 240-241
Keyword(s):  
Methylenetetrahydrofolate Reductase ◽  
Homocysteine Level ◽  
Pulmonary Thromboembolism ◽  
Plasma Homocysteine ◽  
C677t Polymorphism ◽  
Normal Range ◽  
Plasma Homocysteine Level

Methylenetetrahydrofolate reductase gene C677T mutation and plasma homocysteine level in Beh�et's disease

2003 ◽  
Vol 23 (5) ◽  
pp. 236-240 ◽  
Author(s):  
Abdullah Canataroglu ◽  
Kahraman Tanriverdi ◽  
Tamer Inal ◽  
Gulsah Seydaoglu ◽  
Didem Arslan ◽  
...  
Keyword(s):  
Methylenetetrahydrofolate Reductase ◽  
Homocysteine Level ◽  
Plasma Homocysteine ◽  
Plasma Homocysteine Level ◽  
Reductase Gene ◽  
C677t Mutation ◽  
Methylenetetrahydrofolate Reductase Gene

Lack of carotid stiffening associated with MTHFR 677TT genotype in cardiorespiratory fit adults

2010 ◽  
Vol 42 (2) ◽  
pp. 259-265 ◽  
Author(s):  
Motoyuki Iemitsu ◽  
Haruka Murakami ◽  
Kiyoshi Sanada ◽  
Kenta Yamamoto ◽  
Hiroshi Kawano ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Cardiorespiratory Fitness ◽  
Methylenetetrahydrofolate Reductase ◽  
Homocysteine Level ◽  
Mthfr C677t ◽  
Plasma Homocysteine ◽  
C677t Polymorphism ◽  
Significant Interaction Effect ◽  
Mthfr C677t Polymorphism ◽  
Fitness Level

The TT genotype of C677T polymorphism in 5,10-methylenetetrahydrofolate reductase (MTHFR) induces elevation of homocysteine level and leads to atherosclerosis and arterial stiffening. Furthermore, cardiorespiratory fitness level is also associated with arterial stiffness. In the present study, a cross-sectional investigation of 763 Japanese men and women (18–70 yr old) was performed to clarify the effects of cardiorespiratory fitness on the relationship between arterial stiffness and MTHFR C677T gene polymorphism. Arterial stiffness was assessed by carotid β-stiffness with ultrasonography and tonometry. The study subjects were divided into high-cardiorespiratory fitness (High-Fit) and low-cardiorespiratory fitness (Low-Fit) groups based on the median value of peak oxygen uptake in each sex and decade. The plasma homocysteine level was higher in the TT genotype of MTHFR C677T polymorphism compared with CC and CT genotype individuals. MTHFR C677T polymorphism showed no effect on carotid β-stiffness, but there was a significant interaction effect between fitness and MTHFR C677T polymorphism on carotid β-stiffness ( P = 0.0017). In the Low-Fit subjects, carotid β-stiffness was significantly higher in individuals with the TT genotype than the CC and CT genotypes. However, there were no such differences in High-Fit subjects. In addition, β-stiffness and plasma homocysteine levels were positively correlated in Low-Fit subjects with the TT genotype ( r = 0.71, P < 0.0001), but no such correlations were observed in High-Fit subjects. In CC and CT genotype individuals, there were also no such correlations in either fitness level. These results suggest that the higher cardiorespiratory fitness may attenuate central artery stiffening associated with MTHFR C677T polymorphism.

Investigation of the association between C677T polymorphism of theMTHFRgene and plasma homocysteine level in recurrent fetal miscarriage

2019 ◽  
Vol 45 (8) ◽  
pp. 1442-1447 ◽  
Author(s):  
Yalda Zarfeshan Fard ◽  
Omid Kooshkaki ◽  
Dormohammad Kordi Tammandani ◽  
Gholamreza Anani Sarab
Keyword(s):  
Homocysteine Level ◽  
Plasma Homocysteine ◽  
C677t Polymorphism ◽  
Plasma Homocysteine Level
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