scholarly journals LOW REPRODUCIBILITY OF THE SERUM GALACTOMANNAN ANTIGEN ASSAY IN PATIENTS WITH DEFINITE AND SUSPECTED INVASIVE PULMONARY ASPERGILLOSIS

Respirology ◽  
2019 ◽  
Vol 24 (S2) ◽  
pp. 130-130
Keyword(s):  
Invasive Pulmonary Aspergillosis ◽  
Pulmonary Aspergillosis ◽  
Antigen Assay ◽  
Galactomannan Antigen

scholarly journals Utility of serum galactomannan antigen testing combined with chest computed tomography for early diagnosis of invasive pulmonary aspergillosis in patients with hematological malignancies with febrile neutropenia after antifungal drug treatment

2018 ◽  
Vol 47 (2) ◽  
pp. 783-790 ◽  
Author(s):  
Xiaoning Wang ◽  
Guili Guo ◽  
Ruibo Cai ◽  
Pengcheng He ◽  
Mei Zhang
Keyword(s):  
Early Diagnosis ◽  
Febrile Neutropenia ◽  
Hematological Malignancies ◽  
Invasive Pulmonary Aspergillosis ◽  
Chest Ct ◽  
Antifungal Drugs ◽  
Control Group ◽  
Pulmonary Aspergillosis ◽  
Galactomannan Antigen ◽  
Observational Group

Objective To investigate the value of serum galactomannan antigen (GM) testing combined with chest computed tomography (CT) as a noninvasive method for early diagnosis of invasive pulmonary aspergillosis (IPA) in patients with hematological malignancies with febrile neutropenia after antifungal drug treatment. Methods We retrospectively analyzed the data of 376 patients with febrile neutropenia from January 2015 to August 2017. All patients were given broad-spectrum antibiotics and divided into the control group (effective antibiotic treatment, no antifungal drugs given) and the observational group (ineffective antibiotic treatment, antifungal drugs given). The serum GM testing, chest CT, and microbiological examination findings were compared between the two groups. Results The false-positive rates of GM testing for IPA in the control and observational groups were 4.04% and 8.65%, respectively, and the false-negative rates in the two groups were 1.10% and 9.62%, respectively. Sixty-five patients in the observational group and 11 in the control group had typical features of CT imaging. Conclusion Clinical weekly screening of serum GM and chest CT may be an effective combined approach to the early diagnosis of IPA in patients with febrile neutropenia, even if they have undergone antifungal treatment.

scholarly journals Comparison between PCR and Detection of Antigen in Sera for Diagnosis of Pulmonary Aspergillosis

1999 ◽  
Vol 37 (1) ◽  
pp. 218-220 ◽  
Author(s):  
Sumio Kawamura ◽  
Shigefumi Maesaki ◽  
Tetsuhiro Noda ◽  
Youichi Hirakata ◽  
Kazunori Tomono ◽  
...  
Keyword(s):  
Nested Pcr ◽  
Allergic Bronchopulmonary Aspergillosis ◽  
Invasive Pulmonary Aspergillosis ◽  
Latex Agglutination ◽  
Agglutination Test ◽  
Enzyme Linked Immunosorbent Assay ◽  
Serum Samples ◽  
Pulmonary Aspergillosis ◽  
Pulmonary Aspergilloma ◽  
Galactomannan Antigen

We evaluated the usefulness of PCR and antigen detection for the diagnosis of pulmonary aspergillosis. Forty-four serum samples from patients with pulmonary aspergillosis (33 with pulmonary aspergilloma, 4 with allergic bronchopulmonary aspergillosis, 4 with invasive pulmonary aspergillosis, and 3 with aspergillus pyothorax) were used in this study. PCR detection of Aspergillus DNA in serum samples was successful in 39 patients. Galactomannan antigen was detected by sandwich enzyme-linked immunosorbent assay in 25 patients and by latex agglutination test in 13 patients. Detection ofAspergillus DNA in serum samples by nested PCR had the highest sensitivity of the three methods tested for the diagnosis of pulmonary aspergillosis.

A strategy based on galactomannan antigen detection and PCR for invasive pulmonary aspergillosis following influenza A (H1N1) pneumonia

2012 ◽  
Vol 65 (5) ◽  
pp. 470-473 ◽  
Author(s):  
Christophe Guervilly ◽  
Antoine Roch ◽  
Stéphane Ranque ◽  
Jean-Marie Forel ◽  
Sami Hraiech ◽  
...  
Keyword(s):  
Influenza A ◽  
Invasive Pulmonary Aspergillosis ◽  
Antigen Detection ◽  
Pulmonary Aspergillosis ◽  
Influenza A H1n1 ◽  
Galactomannan Antigen ◽  
H1n1 Pneumonia
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