scholarly journals THE EFFECTIVE MIGRATION AND ANTI‐INFLAMMATORY EFFECTS OF HUMAN DERMAL‐DERIVED MESENCHYMAL STEM CELLS IN ENDOTOXIN‐INDUCED EXPERIMENTAL MOUSE MODEL

Respirology ◽  
2019 ◽  
Vol 24 (S2) ◽  
pp. 13-13
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Mouse Model ◽  
Experimental Mouse Model ◽  
Experimental Mouse ◽  
Anti Inflammatory

scholarly journals Anti-inflammatory effects of ozonated water in an experimental mouse model

2014 ◽  
Vol 2 (5) ◽  
pp. 671-674 ◽  
Author(s):  
KAZUO AZUMA ◽  
TAKURO MORI ◽  
KINYA KAWAMOTO ◽  
KOHEI KURODA ◽  
TAKESHI TSUKA ◽  
...  
Keyword(s):  
Mouse Model ◽  
Experimental Mouse Model ◽  
Experimental Mouse ◽  
Anti Inflammatory ◽  
Ozonated Water

scholarly journals Anti-inflammatory Role of Mesenchymal Stem Cells in an Acute Lung Injury Mouse Model

2018 ◽  
Vol 33 (3) ◽  
pp. 154-161 ◽  
Author(s):  
Jin Won Huh ◽  
Won Young Kim ◽  
Yun Young Park ◽  
Chae-Man Lim ◽  
Younsuck Koh ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Mouse Model ◽  
Anti Inflammatory

Ginger rhizome enhances the anti-inflammatory and anti-nociceptive effects of paracetamol in an experimental mouse model of fibromyalgia

2018 ◽  
Vol 26 (4) ◽  
pp. 1093-1101 ◽  
Author(s):  
Sergio Montserrat-de la Paz ◽  
Maria Dolores Garcia-Gimenez ◽  
Ana Maria Quilez ◽  
Rocio De la Puerta ◽  
Angeles Fernandez-Arche
Keyword(s):  
Mouse Model ◽  
Experimental Mouse Model ◽  
Ginger Rhizome ◽  
Experimental Mouse ◽  
Anti Inflammatory

scholarly journals Intestinal anti-inflammatory activity of Ulva ohnoi oil in DSS-induced experimental mouse model

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
JeongEun Kang ◽  
JiSun Park ◽  
Jung-Kil Seo ◽  
WonHyung Choi ◽  
SooCheol Choi ◽  
...  
Keyword(s):  
Mouse Model ◽  
Large Scale ◽  
Physiological Activity ◽  
Animal Experiments ◽  
Green Tide ◽  
Control Group ◽  
Experimental Mouse Model ◽  
Experimental Mouse ◽  
Ulva Ohnoi ◽  
Anti Inflammatory

AbstractThis study was conducted to examine the physiological activity of Ulva ohnoi, some of which may be used for food or natural products but could disturbing coastal ecosystems due to large scale green-tide, to check values of U. ohnoi oil through experimental results. U. ohnoi oil was extracted from bulk of Ulva biomass to confirm its antioxidant and antibacterial activity, and the efficacy of U. ohnoi oil in the state of inflammation was confirmed through animal experiments. To confirm the anti-inflammatory effect, a mouse model induced with DSS was used. As a result of measuring NO using plasma after induction of inflammation, the amount of NO produced in the U. ohnoi oil group was decreased compared to the control group. Expression of inflammatory cytokines TNF-α, IL-6, and IL-1β was decreased compared to the control group. As a result of observing H&E staining, lower crypt loss and inflammatory cell infiltration were found in the U. ohnoi oil group compared to the control group. Consequently, U. ohnoi oil appears to have great anti-inflammatory properties.

scholarly journals Extracellular Vesicles Do Not Mediate the Anti-Inflammatory Actions of Mouse-Derived Adipose Tissue Mesenchymal Stem Cells Secretome

2021 ◽  
Vol 22 (3) ◽  
pp. 1375
Author(s):  
María Carmen Carceller ◽  
María Isabel Guillén ◽  
María Luisa Gil ◽  
María José Alcaraz
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Adipose Tissue ◽  
Extracellular Vesicles ◽  
Nuclear Factor Κb ◽  
Peritoneal Macrophages ◽  
Toll Like Receptor 4 ◽  
Anti Inflammatory ◽  
Phagocytic Response

Adipose tissue represents an abundant source of mesenchymal stem cells (MSC) for therapeutic purposes. Previous studies have demonstrated the anti-inflammatory potential of adipose tissue-derived MSC (ASC). Extracellular vesicles (EV) present in the conditioned medium (CM) have been shown to mediate the cytoprotective effects of human ASC secretome. Nevertheless, the role of EV in the anti-inflammatory effects of mouse-derived ASC is not known. The current study has investigated the influence of mouse-derived ASC CM and its fractions on the response of mouse-derived peritoneal macrophages against lipopolysaccharide (LPS). CM and its soluble fraction reduced the release of pro-inflammatory cytokines, adenosine triphosphate and nitric oxide in stimulated cells. They also enhanced the migration of neutrophils or monocytes, in the absence or presence of LPS, respectively, which is likely related to the presence of chemokines, and reduced the phagocytic response. The anti-inflammatory effect of CM may be dependent on the regulation of toll-like receptor 4 expression and nuclear factor-κB activation. Our results demonstrate the anti-inflammatory effects of mouse-derived ASC secretome in mouse-derived peritoneal macrophages stimulated with LPS and show that they are not mediated by EV.

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