scholarly journals GENOTYPIC CHARACTERISTICS OF CARBAPENEM-RESISTANT ENTEROBACTERIACEAEIN ONE OF SECONDARY REFERRAL HOSPITAL IN SOUTH KOREA

Respirology ◽  
2018 ◽  
Vol 23 ◽  
pp. 303-304
Keyword(s):  
South Korea ◽  
Referral Hospital ◽  
Carbapenem Resistant ◽  
Genotypic Characteristics ◽  
Secondary Referral Hospital

Phenotypic and genotypic characteristics of a Carbapenem-resistant Serratia marcescens cohort and outbreak: describing an opportunistic pathogen

2021 ◽  
pp. 106463
Author(s):  
Gladys Villas Boas do Prado ◽  
Elisa Teixeira Mendes ◽  
Roberta Cristina Ruedas Martins ◽  
Lauro Vieira Perdigão-Neto ◽  
Maristela Pinheiro Freire ◽  
...  
Keyword(s):  
Serratia Marcescens ◽  
Opportunistic Pathogen ◽  
Carbapenem Resistant ◽  
Genotypic Characteristics

The changing epidemiology of carbapenemase-producing Klebsiella pneumoniae in Italy: toward polyclonal evolution with emergence of high-risk lineages

2020 ◽  
Author(s):  
Vincenzo Di Pilato ◽  
Giulia Errico ◽  
Monica Monaco ◽  
Tommaso Giani ◽  
Maria Del Grosso ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
High Risk ◽  
Klebsiella Pneumoniae ◽  
Close Association ◽  
Sensu Stricto ◽  
Colistin Resistance ◽  
Carbapenem Resistant ◽  
Invasive Infections ◽  
Encoding Gene ◽  
Genotypic Characteristics

Abstract Background Previous studies showed that the epidemic of carbapenem-resistant Klebsiella pneumoniae (CR-KP) observed in Italy since 2010 was sustained mostly by strains of clonal group (CG) 258 producing KPC-type carbapenemases. In the framework of the National Antibiotic-Resistance Surveillance (AR-ISS), a countrywide survey was conducted in 2016 to explore the evolution of the phenotypic and genotypic characteristics of CR-KP isolates. Methods From March to July 2016, hospital laboratories participating in AR-ISS were requested to provide consecutive, non-duplicated CR-KP (meropenem and/or imipenem MIC >1 mg/L) from invasive infections. Antibiotic susceptibility was determined according to EUCAST recommendations. A WGS approach was adopted to characterize the isolates by investigating phylogeny, resistome and virulome. Results Twenty-four laboratories provided 157 CR-KP isolates, of which 156 were confirmed as K. pneumoniae sensu stricto by WGS and found to carry at least one carbapenemase-encoding gene, corresponding in most cases (96.1%) to blaKPC. MLST- and SNP-based phylogeny revealed that 87.8% of the isolates clustered in four major lineages: CG258 (47.4%), with ST512 as the most common clone, CG307 (19.9%), ST101 (15.4%) and ST395 (5.1%). A close association was identified between lineages and antibiotic resistance phenotypes and genotypes, virulence traits and capsular types. Colistin resistance, mainly associated with mgrB mutations, was common in all major lineages except ST395. Conclusions This WGS-based survey showed that, although CG258 remained the most common CR-KP lineage in Italy, a polyclonal population has emerged with the spread of the new high-risk lineages CG307, ST101 and ST395, while KPC remained the most common carbapenemase.

scholarly journals Prevalence of rifampicin resistant tuberculosis and associated factors among presumptive tuberculosis patients in a secondary referral hospital in Lagos Nigeria

2018 ◽  
Vol 18 (3) ◽  
pp. 472 ◽  
Author(s):  
Olusola Adedeji Adejumo ◽  
Bolanle Olusola-Faleye ◽  
Victor Adepoju ◽  
Abimbola Bowale ◽  
Sunday Adesola ◽  
...  
Keyword(s):  
Associated Factors ◽  
Referral Hospital ◽  
Tuberculosis Patients ◽  
Resistant Tuberculosis ◽  
Secondary Referral Hospital
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