scholarly journals THE ROLE OF SODIUM-POTASSIUM-CHLORIDE COTRANSPORTER IN LPS-INDUCED ALVEOLAR MACROPHAGE ACTIVATION

Respirology ◽  
2018 ◽  
Vol 23 ◽  
pp. 229-230
Keyword(s):  
Potassium Chloride ◽  
Alveolar Macrophage ◽  
Macrophage Activation ◽  
Sodium Potassium ◽  
Sodium Potassium Chloride Cotransporter

scholarly journals Role of the Cation-Chloride-Cotransporters in Cardiovascular Disease

Cells ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 2293 ◽  
Author(s):  
Nur Farah Meor Azlan ◽  
Jinwei Zhang
Keyword(s):  
Cardiovascular Disease ◽  
Potassium Chloride ◽  
Genetic Disorders ◽  
Ion Homeostasis ◽  
Cell Volume Regulation ◽  
Renal Cells ◽  
Sodium Potassium ◽  
Physiological Processes ◽  
Cation Chloride Cotransporters

The SLC12 family of cation-chloride-cotransporters (CCCs) is comprised of potassium chloride cotransporters (KCCs), which mediate Cl− extrusion and sodium-potassium chloride cotransporters (N[K]CCs), which mediate Cl− loading. The CCCs play vital roles in cell volume regulation and ion homeostasis. The functions of CCCs influence a variety of physiological processes, many of which overlap with the pathophysiology of cardiovascular disease. Although not all of the cotransporters have been linked to Mendelian genetic disorders, recent studies have provided new insights into their functional role in vascular and renal cells in addition to their contribution to cardiovascular diseases. Particularly, an imbalance in potassium levels promotes the pathogenesis of atherosclerosis and disturbances in sodium homeostasis are one of the causes of hypertension. Recent findings suggest hypothalamic signaling as a key signaling pathway in the pathophysiology of hypertension. In this review, we summarize and discuss the role of CCCs in cardiovascular disease with particular emphasis on knowledge gained in recent years on NKCCs and KCCs.

scholarly journals The Movement of Solutes Across the Epithelium of the Ducts and Cisterns in the Mammary Gland of the Ewe

1965 ◽  
Vol 18 (5) ◽  
pp. 1035 ◽  
Author(s):  
DDS Mackenzie ◽  
AK Lascelles
Keyword(s):  
Mammary Gland ◽  
Water Absorption ◽  
Potassium Chloride ◽  
Chloride Ions ◽  
Rate Of Change ◽  
Milk Secretion ◽  
Sodium Potassium ◽  
Lactose Concentration

The role of the cisterns and large ducts in the overall process of milk secretion has been studied in experiments which have been carried out to determine the change in composition of solutions injected into the mammary gland cisterns of lactating and dry ewes. These solutions contained electrolytes, lactose, and a marker substance and were allowed to remain in the gland for periods of up to 4 hr. The concentration of sodium, potassium, chloride, and lactose in the solution injected into lactating glands approached with time that in milk. The data indicated that the rate of change in concentration of sodium, potassium, and chloride was more rapid than could be accounted for by the mixing of the injected solution with milk from the ducts. Sodium, potassium, and chloride ions were secreted into solutions in which the concentrations of these ions were lower than those in milk and sodium and chloride ions were absorbed from solutions in which their concentration was higher than that in milk. Water absorption occurred from the solutions containing sodium and chloride ata higher concentration than that in milk. In the dry gland the composition of the solutions injected approached with time that of involution secretion which has a higher sodium and chloride and lower potassium and lactose concentration than normal milk. Lactose was absorbed from dry glands but not from the lactating glands.

Different role of serum components and cytokines on alveolar macrophage activation by soluble fungal (1→3)-β-d-glucan

1997 ◽  
Vol 334 (2-3) ◽  
pp. 255-263 ◽  
Author(s):  
Teruaki Sakurai ◽  
Toshikazu Kaise ◽  
Toshiro Yadomae ◽  
Chiyo Matsubara
Keyword(s):  
Alveolar Macrophage ◽  
Macrophage Activation ◽  
Serum Components

PGE2MEDIATES OENOCYTOID CELL LYSIS VIA A SODIUM-POTASSIUM-CHLORIDE COTRANSPORTER

2015 ◽  
Vol 89 (4) ◽  
pp. 218-229 ◽  
Author(s):  
Sony Shrestha ◽  
Jiyeong Park ◽  
Seung-Joon Ahn ◽  
Yonggyun Kim
Keyword(s):  
Potassium Chloride ◽  
Cell Lysis ◽  
Sodium Potassium ◽  
Sodium Potassium Chloride Cotransporter
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