scholarly journals THE CHANGE OF NASAL RESISTANCE AT THE ACUTE NASAL CHALLENGE WITH COLD AIR IN ASTHMATICS WITH COLD AIRWAY HYPERRESPONSIVENESS

Respirology ◽  
2018 ◽  
Vol 23 ◽  
pp. 216-216
Keyword(s):  
Airway Hyperresponsiveness ◽  
Nasal Resistance ◽  
Cold Air ◽  
Nasal Challenge

Dynamics of blood and sputum eosinophils in asthma patients with cold airway hyperresponsiveness during cold air provocation

2019 ◽  
Author(s):  
Juliy M. Perelman ◽  
Aleksey B. Pirogov ◽  
Anna G. Prikhodko ◽  
Elena V. Ushakova ◽  
Victor P. Kolosov
Keyword(s):  
Airway Hyperresponsiveness ◽  
Cold Air ◽  
Asthma Patients ◽  
Sputum Eosinophils

Nasal flow-resistive responses to challenge with cold dry air

1992 ◽  
Vol 72 (4) ◽  
pp. 1243-1246 ◽  
Author(s):  
K. P. Strohl ◽  
J. L. Arnold ◽  
M. J. Decker ◽  
P. L. Hoekje ◽  
E. R. McFadden
Keyword(s):  
Healthy Subjects ◽  
Surface Heat ◽  
Nasal Resistance ◽  
Immediate Hypersensitivity ◽  
Functional Responses ◽  
Cold Air ◽  
Dry Air ◽  
Baseline Values ◽  
Per Se ◽  
Nasal Flow

Recent studies have suggested that the inhalation of cold air through the nose is associated with the subsequent release of mediators of immediate hypersensitivity. To determine if mucosal surface heat and water loss influence the nasal functional response to cold air, we measured nasal resistance by posterior rhinomanometry before and 1, 5, and 10 min after a 4-min period of isocapnic hyperventilation (30 l/min) through the nose in nine healthy subjects (5 males, 4 females; aged 25–39 yr) while they inhaled air at 0 degrees C. During the challenge period, the subjects breathed either in and out of the nose or in through the nose and out through the mouth. No changes in nasal resistance developed when subjects breathed exclusively through the nose; however, when subjects breathed in through the nose and out through the mouth, nasal resistance was increased 200% at 1 min (P less than 0.01) after the challenge and returned to baseline values by 10 min after cessation of the challenge. These data indicate that nasal functional responses to cold dry air are dependent on the pattern of the ventilatory challenge. If the heat given up from the nasal mucosa to the incoming air is not recovered during expiration (as is the case with inspiration through the nose and expiration through the mouth), nasal obstruction will occur. Hyperpnea of cold air, per se, does not influence nasal resistance.

COMPARATIVE ASSESSMENT OF AIRWAY CELLULAR INFLAMMATION IN PATIENTS WITH BRONCHIAL ASTHMA IN RESPONSE TO HYPOSMOLAR AND COLD STIMULES

2020 ◽  
Author(s):  
Aleksey Pirogov ◽  
Anna Prikhodko ◽  
Evgeniya Afanas'eva ◽  
Yuliy Perelman
Keyword(s):  
Bronchial Asthma ◽  
Airway Hyperresponsiveness ◽  
Comparative Assessment ◽  
Distilled Water ◽  
Cytological Analysis ◽  
Cold Air ◽  
Cellular Inflammation ◽  
Different Types ◽  
Airway Response ◽  
Inflammatory Pattern

An approach is presented to the study of cellular inflammation using cytological analysis of sputum in patients with bronchial asthma with different types of airway reaction to bronchoprovocation with cold air and distilled water. When the airways are hyperresponsive to hypoosmolar and cold stimuli, it has been established the activation of the neutrophilic component of bronchial granulocytes. Cold airway hyperresponsiveness is associated with an increase in neutrophil content and a concomitant decrease in the number of macrophages in the inflammatory pattern of the bronchi. An increase in sputum cytosis is inherent in a positive airway response to a hypoosmolar test with an unexpressed dynamics of the level of bronchial eosinophils.

scholarly journals Relationship of granulocytic inflammation of bronches with the level of asthma control in patients with cold airway hyperresponsiveness under inhalation therapy of extrafine beclomethasone/formoterol

2021 ◽  
pp. 42-51
Author(s):  
A. B. Pirogov ◽  
A. G. Prikhodko ◽  
J. M. Perelman
Keyword(s):  
Asthma Control ◽  
Airway Hyperresponsiveness ◽  
Inhalation Therapy ◽  
Term Therapy ◽  
Small Airways ◽  
Asthma Control Test ◽  
Cold Air ◽  
Before And After ◽  
Metered Dose ◽  
Asthma Patients

Introduction. Obstruction of small airways in asthma is accompanied by greater hypersensitivity to nonspecific irritants and inflammation activity, which is associated with a worsening of the clinical course of the disease. The combination of beclomethasone dipropionate/formoterol fumarate (BDP/FF), used in the form of an extrafine metered dose aerosol, is capable of having an anti-inflammatory effect on the small airways. Dynamic changes in the structure and function of granulocytes of inflammatory bronchial infiltrate after exposure to cold air in patients with asthma treated with BDP/FF have been little studied.Aim. To study the nature of changes in eosinophil and neutrophil pools of bronchial granulocytes in asthma patients with cold airway hyperresponsiveness (CAHR) during long-term therapy with extrafine BDP/FF.Materials and methods. The clinical study involved 25 asthma patients with CAHR. The design of the work included a questionnaire survey of patients using the Asthma Control Test (ACT) questionnaire, spirometry (Easy on PC, ndd Medizintechnik AG, Switzerland), an isocapnic hyperventilation by cold air (IHCA), collection and cytological examination of induced and spontaneously produced sputum. The examination was carried out at the beginning and after 12 weeks of BDP/FF therapy (100/6 μg, twice a day).Results. 12-week treatment with extrafine BDP/FF led to an improvement in asthma control (ACT increased from 17.1±1.1 to 22.5±0.5 points, p˂0.001) and patency of small bronchi (increase in МEF50 was 0.47±0.21 L/s, МEF25-75 – 0.42±0.17 L/s). BDP/FF therapy had a positive effect on cellular inflammation, leading to a decrease in the number of eosinophils in sputum from 9.5 (3.0; 19.5) to 2.2 (1.3; 4.7)% (p˂0,05). A decrease in the number of eosinophils was also observed after cold bronchoprovocation: from 9.0 (2.8; 15.4) to 4.7 (2.8; 7.8)% (p˂0.05). There was no dynamics in neutrophils after BDP/FF treatment before and after IHCA (59.9±1.3 and 57.1±2.0%, respectively, p>0.05).Conclusion. Improvement of disease control in asthma patients with CAHR after 12 weeks of therapy with extrafine BDP/FF is associated with the regulation of eosinophilic inflammation, a decrease in the number of eosinophils in the airways and suppression of the activity of the neutrophilic pool of bronchial granulocytes in response to cold bronchoprovocation. 

scholarly journals Comparative Prevalence of Asthma in Different Groups of Athletes: A Survey

2004 ◽  
Vol 11 (6) ◽  
pp. 402-406 ◽  
Author(s):  
Jean-Bruno Langdeau ◽  
Hélène Turcotte ◽  
Guy Thibault ◽  
Louis-Philippe Boulet
Keyword(s):  
Family History ◽  
Airway Hyperresponsiveness ◽  
Respiratory Infections ◽  
Hay Fever ◽  
Degree Relative ◽  
Humid Air ◽  
Cold Air ◽  
Dry Air ◽  
History Of

BACKGROUND:The type of air predominantly inhaled during training seems to play an important role in the development of airway hyperresponsiveness in athletes; however, this factor has not been evaluated for asthma.OBJECTIVE AND PATIENTS:To compare the prevalence of self-reported and/or physician-diagnosed asthma among four groups of athletes categorized according to the type of air predominantly inhaled during training: cold air (n=176), dry air (n=384), humid air (n=95), and mixed dry and humid air (n=43).METHOD:Self-administrated questionnaires were used.RESULTS:One hundred seven (15.3%) of the 698 athletes reported having asthma; of these 107 athletes, 92 had physician-diagnosed asthma. No significant differences were found for the prevalence of asthma: 15.9% (cold air), 15.4% (dry air), 12.6% (humid air) and 18.6% (mixed dry and humid air), respectively (P>0.05). Furthermore, no significant differences were observed among the groups for the prevalence of confirmed atopy, cold/flu or respiratory infections (all P>0.05), except for the prevalence of hay fever, which was significantly lower among athletes of the dry air group (P=0.04). Athletes having a first-degree relative with asthma did not have a higher prevalence of asthma than those who did not (P>0.05).CONCLUSION:The prevalence of asthma was not significantly different among the four groups of athletes and it was not associated with a family history of asthma.

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