scholarly journals PROGRESSIVE DISSEMINATED HISTOPLASMOSIS DERIVED FROM ACUTE PULMONARY HISTOPLASMOSIS IN A 61-YEAR-OLD MALE IN NORTH-WESTERN CHINA: A CASE REPORT AND REVIEW OF LITERATURE

Respirology ◽  
2018 ◽  
Vol 23 ◽  
pp. 183-183
Keyword(s):  
Case Report ◽  
Western China ◽  
Review Of Literature ◽  
Disseminated Histoplasmosis ◽  
Pulmonary Histoplasmosis ◽  
Progressive Disseminated Histoplasmosis ◽  
North Western

HISTOPLASMOSIS IN CHILDREN

PEDIATRICS ◽  
1964 ◽  
Vol 33 (6) ◽  
pp. 894-903
Author(s):  
Robert B. Tesh ◽  
Martha H. Shacklette ◽  
Fred H. Diercks ◽  
Daniel Hirschl
Keyword(s):  
Blood Culture ◽  
Amphotericin B ◽  
Positive Blood Culture ◽  
Clinical Studies ◽  
Blood Stream ◽  
Sulfa Drugs ◽  
Serologic Tests ◽  
Disseminated Histoplasmosis ◽  
Pulmonary Histoplasmosis ◽  
Progressive Disseminated Histoplasmosis

Two cases of children with disseminated histoplasmosis and four with acute pulmonary histoplasmosis are presented. The unreliability of basing a diagnosis on the skin and serologic tests early in the course of the disease is stressed. A plea for cultures in those cases clinically suspected of having histoplasmosis is made. A positive blood culture obtained from one child with the acute pulmonary form of the disease lends evidence to the belief that in many cases of acute histoplasmosis, the organism is temporarily disseminated by the blood stream. Two cases of progressive, disseminated histoplasmosis, treated with sulfonamides are presented. This suggests that certain of the sulfa drugs are effective in the treatment of disseminated histoplasmosis, and that controlled clinical studies comparing the effectiveness of sulfa with Amphotericin B are needed.

Progressive disseminated histoplasmosis in the HIV population in Europe in the HAART era. Case report and literature review

Infection ◽  
2014 ◽  
Vol 42 (4) ◽  
pp. 611-620 ◽  
Author(s):  
R. Martin-Iguacel ◽  
J. Kurtzhals ◽  
G. Jouvion ◽  
S. D. Nielsen ◽  
J. M. Llibre
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Disseminated Histoplasmosis ◽  
Progressive Disseminated Histoplasmosis

scholarly journals Cholestasis and disseminated histoplasmosis in a psoriatic patient on infliximab: case report and review of literature

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Steven Park ◽  
Janice Cheong ◽  
Kaitlin Kyi ◽  
Jose Aranez ◽  
Sohaib Abu-Farsakh ◽  
...  
Keyword(s):  
Case Report ◽  
Psoriatic Patient ◽  
Review Of Literature ◽  
Disseminated Histoplasmosis

scholarly journals Disseminated histoplasmosis leading to end stage liver failure in immunocompetent patient: case report and review of literature.

2021 ◽  
Vol 16 (8) ◽  
pp. 2214-2219
Author(s):  
Darshan Gandhi ◽  
Tanmay Gandhi ◽  
Adam Wolfe ◽  
Asim Kichloo ◽  
Jagmeet Singh ◽  
...  
Keyword(s):  
Case Report ◽  
Liver Failure ◽  
Immunocompetent Patient ◽  
Review Of Literature ◽  
Patient Case ◽  
Disseminated Histoplasmosis ◽  
End Stage

scholarly journals Progressive disseminated histoplasmosis with pulmonary and central nervous system involvement: a case report

2021 ◽  
Author(s):  
Matheus Fellipe Nascimento de Souza ◽  
Ana Paula Teixeira da Silva ◽  
Gabriela Santos Bianchin ◽  
Maria Eduarda Angelo de Mendonça Fileti ◽  
Raddib Eduardo Noleto da Nóbrega de Oliveira ◽  
...  
Keyword(s):  
Case Report ◽  
Histoplasma Capsulatum ◽  
Systemic Disease ◽  
Central Nervous System Involvement ◽  
Tnf Alpha ◽  
Cns Involvement ◽  
Necrosis Factor Alpha ◽  
Adequate Treatment ◽  
Disseminated Histoplasmosis ◽  
Progressive Disseminated Histoplasmosis

Context: Histoplasmosis (Histoplasma capsulatum) is a systemic disease that affects the lung and immune system1. The severity of histoplasmosis is directly related to the individual’s immune response since it is an opportunistic pathogen2. It is one of the most prevalent infections in immunocompromised patients due to the use of tumor necrosis factor-alpha (TNF-alpha) inhibitors, resulting in a mortality rate of 20%. The evolution to CNS occurs in 5-10% of patients with disseminated symptoms3. Case Report: M.G.M, a woman, 67 years, was admitted with bilateral tonicclonic seizure with focal onset in the right upper limb. The patient had hypertension, diabetes and rheumatoid arthritis, and was use ASA, glibenclamide, hydrochlorothiazide, losartan, amlodipine, adalimumab and methotrexate. Complementary exams were performed that showed lesions suggestive of microangiopathy on cranial CT; nodular lesions in the pulmonary right upper lobe and prominent lymph nodes in the hilum and mediastinum on chest CT; CSF with increased cytology (monomorphonuclear predominance), without glucose consumption. The biopsy of lung lesions identified Histoplasma capsulatum, confirming the diagnosis of progressive disseminated histoplasmosis with pulmonary and CNS involvement. Thus, treatment with amphotericin B was started, however, the patient died. Conclusions: Histoplasmosis is the most prevalent invasive fungal infection in users of TNF-alpha inhibitors. In these cases, the disease can be more aggressive and have a rapid evolution, with CNS involvement - which confers a worse prognosis. Early diagnosis, suspension of the immunomodulator and adequate treatment for infection control are required.

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