scholarly journals HYPERCAPNIC ACIDOSIS ATTENUATES DECOMPRESSION SICKNESS-INDUCED LUNG INJURY

Respirology ◽  
2018 ◽  
Vol 23 ◽  
pp. 33-34
Keyword(s):  
Lung Injury ◽  
Decompression Sickness ◽  
Hypercapnic Acidosis

Hypercapnic acidosis in acute lung injury: Inevitable side effect or unexpected benefit?*

2008 ◽  
Vol 36 (12) ◽  
pp. 3268-3269
Author(s):  
Mario Perl ◽  
Markus Huber-Lang ◽  
Peter Radermacher
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Side Effect ◽  
Hypercapnic Acidosis

scholarly journals Differential Effects of Buffered Hypercapnia versus  Hypercapnic Acidosis on Shock and Lung Injury Induced by Systemic Sepsis

2009 ◽  
Vol 111 (6) ◽  
pp. 1317-1326 ◽  
Author(s):  
Brendan D. Higgins ◽  
Joseph Costello ◽  
Maya Contreras ◽  
Patrick Hassett ◽  
Daniel O' Toole ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Lung Injury ◽  
Cecal Ligation ◽  
Hypercapnic Acidosis ◽  
Cecal Ligation And Puncture ◽  
Sprague Dawley ◽  
Systemic Sepsis ◽  
Sprague Dawley Rats ◽  
Hemodynamic Deterioration ◽  
Hemodynamic Profile

Background Acute hypercapnic acidosis protects against lung injury caused by nonseptic insults and after both pulmonary and systemic sepsis. The authors wished to dissect the contribution of the acidosis versus hypercapnia per se to the effects of hypercapnic acidosis on the hemodynamic profile and severity of lung injury induced by systemic sepsis. Methods In the hypercapnic acidosis series, adult male Sprague-Dawley rats were randomized to normocapnia or hypercapnic acidosis-produced by adding 5% carbon dioxide to the inspired gas-and cecal ligation and puncture performed. In the buffered hypercapnia series, animals were first randomized to housing under conditions of environmental normocapnia or hypercapnia-produced by exposure to 8% carbon dioxide-to allow renal buffering. After 96 h, cecal ligation and puncture was performed. In both series, the animals were ventilated for 6 h, and the severity of the lung injury and hemodynamic deterioration were assessed. Results Both hypercapnic acidosis and buffered hypercapnia attenuated the development and severity of hypotension and reduced lactate accumulation compared to normocapnia. Hypercapnic acidosis reduced lung injury and inflammation, decreased mean (+ or - SD) bronchoalveolar lavage protein concentration (232 + or - 50 versus 279 + or - 27 microg x ml(-1)) and median neutrophil counts (3,370 versus 9,120 cells x ml(-1)), and reduced histologic lung injury. In contrast, buffered hypercapnia did not reduce the severity of systemic sepsis induced lung injury. Conclusions Both hypercapnic acidosis and buffered hypercapnia attenuate the hemodynamic consequences of systemic sepsis. In contrast, hypercapnic acidosis, but not buffered hypercapnia, reduced the severity of sepsis-induced lung injury.

Hypercapnic acidosis attenuates ventilation-induced lung injury by a nuclear factor-κB–dependent mechanism

2012 ◽  
Vol 40 (9) ◽  
pp. 2622-2630 ◽  
Author(s):  
Maya Contreras ◽  
Bilal Ansari ◽  
Gerard Curley ◽  
Brendan D. Higgins ◽  
Patrick Hassett ◽  
...  
Keyword(s):  
Lung Injury ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Hypercapnic Acidosis ◽  
Ventilation Induced Lung Injury ◽  
Dependent Mechanism

Hypercapnic acidosis attenuates shock and lung injury in early and prolonged systemic sepsis

2009 ◽  
Vol 37 (8) ◽  
pp. 2412-2420 ◽  
Author(s):  
Joseph Costello ◽  
Brendan Higgins ◽  
Maya Contreras ◽  
Martina Ni Chonghaile ◽  
Patrick Hassett ◽  
...  
Keyword(s):  
Lung Injury ◽  
Hypercapnic Acidosis ◽  
Systemic Sepsis

scholarly journals Buffering Hypercapnic Acidosis Worsens Acute Lung Injury

2000 ◽  
Vol 161 (1) ◽  
pp. 141-146 ◽  
Author(s):  
JOHN G. LAFFEY ◽  
DOREEN ENGELBERTS ◽  
BRIAN P. KAVANAGH
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Hypercapnic Acidosis

scholarly journals Hypercapnic Acidosis Attenuates Lung Injury Induced by Established Bacterial Pneumonia

2008 ◽  
Vol 109 (5) ◽  
pp. 837-848 ◽  
Author(s):  
Martina Ni Chonghaile ◽  
Brendan D. Higgins ◽  
Joseph Costello ◽  
John G. Laffey
Keyword(s):  
Carbon Dioxide ◽  
Lung Injury ◽  
Antibiotic Therapy ◽  
Ischemia Reperfusion ◽  
Lung Compliance ◽  
In Vivo Model ◽  
Hypercapnic Acidosis ◽  
Sprague Dawley ◽  
E Coli

Background Hypercapnic acidosis protects against lung injury after ischemia-reperfusion, endotoxin-induced and ventilation-induced lung injury. The effects of hypercapnic acidosis in the setting of established pulmonary sepsis are not known. The authors investigated whether hypercapnic acidosis -- induced by adding carbon dioxide to inspired gas -- would be beneficial or deleterious in established Escherichia coli pneumonia in an in vivo model, in the presence and absence of antibiotic therapy. Methods Adult male Sprague-Dawley rats were anesthetized and ventilated. In the first set of experiments, rats were anesthetized, E. coli (5-6.4 x 10(9)/ml colony-forming units) was instilled intratracheally, and the animals were allowed to recover. After 6 h, during which time a severe pneumonia developed, they were reanesthetized and randomly assigned to normocapnia (fraction of inspired carbon dioxide [Fico(2)] = 0.00, n = 10) or hypercapnic acidosis (Fico(2) = 0.05, n = 10). The second set of experiments was performed in a manner identical to that of series 1, but all rats (n = 10 per group) were given intravenous ceftriaxone (30 mg/kg) at randomization. All animals received normocapnia or hypercapnic acidosis for 6 h, and the severity of lung injury was assessed. Results In the absence of antibiotic therapy, hypercapnic acidosis reduced the pneumonia-induced increase in peak airway pressure and the decrease in static lung compliance compared with control conditions. In the presence of antibiotic therapy, which substantially reduced lung bacterial counts, hypercapnic acidosis significantly attenuated the extent of pneumonia-induced histologic injury. Conclusions Hypercapnic acidosis reduced the magnitude of the lung injury induced by established E. coli pneumonia.

Hypercapnic Acidosis Is Protective in anIn VivoModel of Ventilator-induced Lung Injury

2002 ◽  
Vol 166 (3) ◽  
pp. 403-408 ◽  
Author(s):  
Scott E. Sinclair ◽  
David A. Kregenow ◽  
Wayne J. E. Lamm ◽  
Ian R. Starr ◽  
Emil Y. Chi ◽  
...  
Keyword(s):  
Lung Injury ◽  
Hypercapnic Acidosis ◽  
Ventilator Induced Lung Injury
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