scholarly journals THE VALUE OF RESPIRATORY BIPHASIC PULSE OSCILLATION INDEX IN DIFFERENTIAL DIAGNOSIS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND ASTHMA AND THE DIAGNOSIS OF EMPHYSEMA

Respirology ◽  
2018 ◽  
Vol 23 ◽  
pp. 18-18
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Differential Diagnosis ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Biphasic Pulse

Chronic Obstructive Pulmonary Disease

2014 ◽  
pp. 334-345 ◽  
Author(s):  
John J. Reilly
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Health Care ◽  
Differential Diagnosis ◽  
Pulmonary Disease ◽  
Airflow Obstruction ◽  
Health Care Practitioner ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Definition Of ◽  
The U.S

Virtually every health care practitioner who provides care to adults will encounter individuals with chronic obstructive pulmonary disease (COPD). Current estimates of the prevalence of the condition vary based on the method of ascertainment: most surveys show that approximately 6% of adults report a doctor's diagnosis of COPD but that approximately 25% have airflow obstruction when assessed by spirometry. COPD is common, morbid, mortal, and expensive: estimates are that 〉20 million U.S. adults have COPD and that it is responsible for 〉120,000 deaths annually with a cost to the U.S. economy of more than $38 billion. This chapter describes the definition of COPD, presenting clinical symptomatology and evaluation, natural history, differential diagnosis, current concepts of pathogenesis, therapeutic options, and the evaluation of a patient with known or suspected COPD considering surgery.

Surface Proteome of Plasma Extracellular Vesicles as Biomarkers for Pneumonia and Acute Exacerbation of Chronic Obstructive Pulmonary Disease

2019 ◽  
Author(s):  
Anna Lena Jung ◽  
Malene Møller Jørgensen ◽  
Rikke Bæk ◽  
Kathrin Griss ◽  
Maria Han ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Differential Diagnosis ◽  
Pulmonary Disease ◽  
Acute Exacerbation ◽  
Extracellular Vesicles ◽  
Cytotoxic T Lymphocyte ◽  
Area Under The Curve ◽  
Chronic Obstructive ◽  
Healthy Controls ◽  
Obstructive Pulmonary Disease

Abstract Background Community-acquired pneumonia (CAP) and acute exacerbation of chronic obstructive pulmonary disease (AECOPD) represent a major burden of disease and death and their differential diagnosis is critical. A potential source of relevant accessible biomarkers are blood-borne small extracellular vesicles (sEVs). Methods We performed an extracellular vesicle array to find proteins on plasma sEVs that are differentially expressed and possibly allow the differential diagnosis between CAP and AECOPD. Plasma samples were analyzed from 21 healthy controls, 24 patients with CAP, and 10 with AECOPD . The array contained 40 antibodies to capture sEVs, which were then visualized with a cocktail of biotin-conjugated CD9, CD63, and CD81 antibodies. Results We detected significant differences in the protein decoration of sEVs between healthy controls and patients with CAP or AECOPD. We found CD45 and CD28 to be the best discrimination markers between CAP and AECOPD in receiver operating characteristic analyses, with an area under the curve >0.92. Additional ensemble feature selection revealed the possibility to distinguish between CAP and AECOPD even if the patient with CAP had COPD, with a panel of CD45, CD28, CTLA4 (cytotoxic T-lymphocyte-associated protein 4), tumor necrosis factor–R-II, and CD16. Conclusion The discrimination of sEV-associated proteins is a minimally invasive method with potential to discriminate between CAP and AECOPD.

scholarly journals OPPORTUNITIES OF LOW-DOSE DIGITAL FLUOROGRAPHY IN DIAGNOSIS OF PHENOTYPIC VARIANTS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

2018 ◽  
Vol 99 (4) ◽  
pp. 191-196
Author(s):  
N. A. Gorbunov ◽  
A. P. Dergilev ◽  
V. I. Kochura ◽  
Ya. L. Manakova ◽  
S. N. Volchenko ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Differential Diagnosis ◽  
Pulmonary Disease ◽  
Optical Density ◽  
Low Dose ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
X Ray ◽  
Average Value ◽  
Lung Emphysema

Objective. To determine the opportunities of low-dose digital fluorography (LDDF) in differential diagnosis of phenotypic variants of chronic obstructive pulmonary disease (COPD).Material and methods. There were 107 patients with clinically diagnosed COPD of varying severity examined. The average age of the patients was 51.8±1.5 years (46–59 years). All patients for LDDF of the chest in the frontal projection in the inspiratory and expiratory phase of respiration were undergone.Results. The electron optical density of the lungs was determined in the upper, middle and lower zones of both lungs. As a result in patients with a predominance of emphysematous variant of COPD (n=15) the most characteristic radiological symptom was lung hyperventilation (14% of 107 patients) and inspiratory electron optical density value was 748.18±4.72 optical density units (ODU). In patients with a predominance of bronchitic variant of COPD (n=43) the most common radiological symptom was the presence of symptom amplification and deformation of lung pattern (40% of 107 patients) and inspiratory electron optical density value was 668.04±12.26 ODU. For patients with mixed phenotypic variant of COPD (n=49) it was characterized by a combination of X-ray symptom amplification and deformation of lung pattern with lung emphysema (46% of 107 patients); the average value of inspiratory electron optical density value was 815.24±17.25 ODU.Conclusion. The technique of LDDF can detect X-ray symptoms and determine inspiratory and expiratory electron optical density of the lungs in patients with COPD that allows optimizing the differential diagnosis of phenotypic variants of chronic obstructive pulmonary disease.

scholarly journals CHRONIC OBSTRUCTIVE PULMONARY DISEASE WITH EMPHYSEMA AND GIANT BULLAE IN A SMOKER

2018 ◽  
Vol 99 (4) ◽  
pp. 204-210
Author(s):  
Zh. V. Sheykh ◽  
E. V. Nikolaev ◽  
I. E. Tyurin ◽  
K. G. Zhestkov ◽  
V. G. Alekseev ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Differential Diagnosis ◽  
Pulmonary Disease ◽  
Clinical Case ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Results Of Treatment ◽  
The Status ◽  
Air Cavities

Radiation diagnosis in evaluating chronic obstructive pulmonary disease (COPD) is used to distinguish clinically similar diseases and to identify concomitant pathological changes. Highresolution computed tomography (HRCT) is employed for detailed analysis of the status of the lung. HRCT can visualize primarily centrilobular, panlobular, paraseptal, and bullous emphysema and bronchiectases, is of great importance in the anatomical characteristics of the disease and in the identification of the phenotype of COPD.The paper describes a clinical case of COPD with bullous emphysema in a 60-year-old man. The CT pattern presents with lower-density bilateral multiple centrilobular avascular areas without clear boundaries, as well as by paraseptal emphysema areas, also localized mainly in the lower segments of both lungs, with thin-walled air cavities occupying up to one third of the hemithorax on both sides. CT made it possible to visualize upperlobular centrolobular emphysema, pulmonary bullae, to estimate their sizes, and to identify compression atelectasis in the adjacent lung areas. The differential diagnosis included bronchiectasis disease, histiocytosis X, and lung carcinoma.This clinical case demonstrates that HRCT is the method of choice for differential diagnosis, a follow-up, and assessment of the results of treatment for COPD with a preponderance of bullous emphysema, including in the presence of a doubtful radiographic pattern.

scholarly journals Differential diagnosis of infections in a patient with Chronic Obstructive Pulmonary Disease

2008 ◽  
Vol 2 (4) ◽  
pp. 181-192
Author(s):  
Paolo Ghiringhelli
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Differential Diagnosis ◽  
Pulmonary Disease ◽  
Laboratory Data ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Adequate Treatment ◽  
Lung Cysts ◽  
Chronic Necrotizing Pulmonary Aspergillosis ◽  
Chronic Pulmonary Diseases

We describe a case of a 65-years-old patient with Chronic Obstructive Pulmonary Disease (COPD), receiving oxygen therapy and resistant to antibiotic therapy. He was admitted with high fever, productive cough, marked leukocytosis, and chest X-ray findings of infiltration and fluid levels within lung cysts. A differential diagnosis was essential to start an adequate treatment and avoid the rapid worsening of patients respiratory status. In patients with chronic pulmonary diseases under immunotherapy, micotic infections should be considered. Aspergillus fumigatus was cultured from bronchial washing fluid and we diagnosed chronic necrotizing pulmonary aspergillosis (CNPA). Oral itraconazole was started and his symptoms and laboratory data markedly improved.

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