SYNCHRONOUS MULTIPLE BONE METASTASES FROM A LARGE-CELL NEUROENDOCRINE CARCINOMA WITH RAPID PROGRESSION OF BONE-RELATED EVENTS

Respirology ◽  
2017 ◽  
Vol 22 ◽  
pp. 118-118
Keyword(s):  
Bone Metastases ◽  
Neuroendocrine Carcinoma ◽  
Large Cell ◽  
Large Cell Neuroendocrine Carcinoma ◽  
Rapid Progression ◽  
Multiple Bone Metastases

scholarly journals Symptoms and diagnostics of lung neuroendocrine tumors

2011 ◽  
Vol 152 (10) ◽  
pp. 366-370 ◽  
Author(s):  
Lilla Tamási ◽  
Veronika Müller
Keyword(s):  
Carcinoid Tumor ◽  
Neuroendocrine Tumors ◽  
Neuroendocrine Carcinoma ◽  
Large Cell ◽  
Small Cell ◽  
Large Cell Neuroendocrine Carcinoma ◽  
Rapid Progression ◽  
Small Cell Lung ◽  
Typical Carcinoid ◽  
Cell Lung Carcinoma

Pulmonary neuroendocrine tumors comprise 20% of all lung cancers. They are separated into 4 subgroups: typical carcinoid tumor, atypical carcinoid tumor, large-cell neuroendocrine carcinoma, and small-cell lung carcinoma. The major symptoms present in 60% of patients are cough, hemoptysis, and obstructive pneumonia. They may also exhibit hormonally related symptoms e.g. carcinoid syndrome. Small cell lung cancer is the most common subgroup, with rapid progression, aggressive metastatic potential and the worst prognosis. Large cell neuroendocrine carcinoma is rare but also has a poor prognosis. Typical carcinoid may be accompanied with hormone related symptoms and has the best prognosis; atypical one on the contrary may cause lymph node and distant metastases in half of the cases. Elevated plasma levels of chromogranin-A are present in majority of pulmonary neuroendocrine tumors and act as tumor marker. The mainstay of treatment is radical surgery if possible. In locally advanced or metastatic disease combination chemotherapy and somatostatin-analogues may have beneficial effect. This review focuses on the general features, and current diagnostic options of pulmonary neuroendocrine tumors. Orv. Hetil., 2011, 152, 366–370.

Primary Large Cell Neuroendocrine Carcinoma of the Urinary Bladder

2002 ◽  
Vol 126 (10) ◽  
pp. 1229-1232 ◽  
Author(s):  
Andrew J. Evans ◽  
Jaudah Al-Maghrabi ◽  
John Tsihlias ◽  
Ginette Lajoie ◽  
Joan M. Sweet ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Neuroendocrine Carcinoma ◽  
Metastatic Disease ◽  
Transurethral Resection ◽  
Preoperative Staging ◽  
Muscularis Propria ◽  
Large Cell ◽  
Large Cell Neuroendocrine Carcinoma ◽  
Rapid Progression ◽  
Solitary Lesion

Abstract Reports of primary large cell neuroendocrine carcinomas of the urinary bladder are few; we identified only 2 cases in the literature. Both of these cases involved male patients with rapid progression of disease culminating in death with widespread metastases. We report a case of primary large cell neuroendocrine carcinoma of the bladder, with an admixed minor element of adenocarcinoma, in an 82-year-old man. This solitary lesion arose in a bladder diverticulum lateral to the left ureteric orifice. Two attempts at transurethral resection were unsuccessful at achieving local control. The patient underwent a partial cystectomy with left-sided pelvic lymphadenectomy following preoperative staging investigations that found no metastatic disease. Pathologically, the tumor invaded into the deep aspect of the muscularis propria, without extension into perivesical fat. The lateral resection margin was microscopically positive for tumor, but no malignancy was found in the pelvic lymph nodes. The adenocarcinoma comprised less than 5% of total tumor volume, and areas of transition between the neuroendocrine and adenocarcinoma components were apparent. The patient developed a local recurrence 8 months postoperatively, which was managed by a combination of transurethral resection and radiation therapy. Currently, the patient has no evidence of local or metastatic disease 2 years after initial diagnosis.

Large-cell neuroendocrine carcinoma without immunohistological positivity or serum elevation of CEA until relapse

2008 ◽  
Vol 56 (11) ◽  
pp. 547-550
Author(s):  
Yasutaka Watanabe ◽  
Shunsuke Endo ◽  
Hiroyoshi Tsubochi ◽  
Mitsuhiro Nokubi ◽  
Shinichiro Koyama ◽  
...  
Keyword(s):  
Neuroendocrine Carcinoma ◽  
Large Cell ◽  
Large Cell Neuroendocrine Carcinoma
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