MANAGEMENT OF AIRWAY STENOSIS IN ENDOBRONCHIAL TUBERCULOSIS

Respirology ◽  
2017 ◽  
Vol 22 ◽  
pp. 242-242
Keyword(s):  
Airway Stenosis ◽  
Endobronchial Tuberculosis

Inhalation of TGF-β1 antibody: A new method to inhibit the airway stenosis induced by the endobronchial tuberculosis

2009 ◽  
Vol 73 (6) ◽  
pp. 1065-1066 ◽  
Author(s):  
Jingxi Zhang ◽  
Qiang Li ◽  
Chong Bai ◽  
Yiping Han ◽  
Yi Huang
Keyword(s):  
New Method ◽  
Airway Stenosis ◽  
Endobronchial Tuberculosis ◽  
Tgf Β1

scholarly journals β-elemene alleviates airway stenosis via the ILK/Akt pathway modulated by MIR143HG sponging miR-1275

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Guoying Zhang ◽  
Cheng Xue ◽  
Yiming Zeng
Keyword(s):  
Cell Cycle ◽  
Cell Viability ◽  
Cell Model ◽  
Protective Efficacy ◽  
Rabbit Model ◽  
Akt Pathway ◽  
Loss Of Function ◽  
Airway Stenosis

Abstract Background We have previously found that β-elemene could inhibit the viability of airway granulation fibroblasts and prevent airway hyperplastic stenosis. This study aimed to elucidate the underlying mechanism and protective efficacy of β-elemene in vitro and in vivo. Methods Microarray and bioinformatic analysis were used to identify altered pathways related to cell viability in a β-elemene-treated primary cell model and to construct a β-elemene-altered ceRNA network modulating the target pathway. Loss of function and gain of function approaches were performed to examine the role of the ceRNA axis in β-elemene's regulation of the target pathway and cell viability. Additionally, in a β-elemene-treated rabbit model of airway stenosis, endoscopic and histological examinations were used to evaluate its therapeutic efficacy and further verify its mechanism of action. Results The hyperactive ILK/Akt pathway and dysregulated LncRNA-MIR143HG, which acted as a miR-1275 ceRNA to modulate ILK expression, were suppressed in β-elemene-treated airway granulation fibroblasts; β-elemene suppressed the ILK/Akt pathway via the MIR143HG/miR-1275/ILK axis. Additionally, the cell cycle and apoptotic phenotypes of granulation fibroblasts were altered, consistent with ILK/Akt pathway activity. In vivo application of β-elemene attenuated airway granulation hyperplasia and alleviated scar stricture, and histological detections suggested that β-elemene's effects on the MIR143HG/miR-1275/ILK axis and ILK/Akt pathway were in line with in vitro findings. Conclusions MIR143HG and ILK may act as ceRNA to sponge miR-1275. The MIR143HG/miR-1275/ILK axis mediates β-elemene-induced cell cycle arrest and apoptosis of airway granulation fibroblasts by modulating the ILK/Akt pathway, thereby inhibiting airway granulation proliferation and ultimately alleviating airway stenosis.

scholarly journals Multiplanar Reconstructed Thoracic CT Bronchoscopy in Endobronchial Tuberculosis

2012 ◽  
Vol 9 (4) ◽  
pp. 234-6 ◽  
Author(s):  
Fariba Rezaeetalab ◽  
Donya Farrokh ◽  
Behrouz Zandiee
Keyword(s):  
Thoracic Ct ◽  
Endobronchial Tuberculosis

Role of Vascular Endothelial Growth Factor a in Children with Acquired Airway Stenosis

2007 ◽  
Vol 116 (6) ◽  
pp. 430-435 ◽  
Author(s):  
Reza Rahbar ◽  
Lawrence F. Brown ◽  
Judah Folkman ◽  
Trevor J. McGill ◽  
Gerald B. Healy ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Vascular Endothelial ◽  
Airway Stenosis ◽  
Endothelial Growth Factor

Endobronchial Tuberculosis: Report of 102 Cases

CHEST Journal ◽  
1994 ◽  
Vol 105 (6) ◽  
pp. 1910 ◽  
Author(s):  
Shen-Yuan Wang ◽  
Xin-Shan Zhang
Keyword(s):  
Endobronchial Tuberculosis

Long-term Outcome of Short Metallic Stents for Lobar Airway Stenosis

2017 ◽  
Vol 24 (3) ◽  
pp. 211-215 ◽  
Author(s):  
Oren Fruchter ◽  
Bayya Abed El Raouf ◽  
Dror Rosengarten ◽  
Mordechai R. Kramer
Keyword(s):  
Metallic Stents ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Airway Stenosis
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