LEUKOCYTOSIS AS A SIGNIFICANT POOR PROGNOSTIC FACTOR IN MALIGNANT PLEURAL MESOTHELIOMA PRODUCING GRANULOCYTE-COLONY STIMULATING FACTOR: TWO CASE REPORTS AND LITERATURE REVIEW

Respirology ◽  
2017 ◽  
Vol 22 ◽  
pp. 192-192
Keyword(s):  
Prognostic Factor ◽  
Literature Review ◽  
Malignant Pleural Mesothelioma ◽  
Case Reports ◽  
Pleural Mesothelioma ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Poor Prognostic Factor ◽  
Stimulating Factor

scholarly journals Granulocyte Colony-Stimulating Factor-Producing Malignant Pleural Mesothelioma

2007 ◽  
Vol 2 (3) ◽  
pp. 257-258 ◽  
Author(s):  
Noriyasu Usami ◽  
Mika Uchiyama ◽  
Koji Kawaguchi ◽  
Ayuko Yasuda ◽  
Shimon Ito ◽  
...  
Keyword(s):  
Malignant Pleural Mesothelioma ◽  
Pleural Mesothelioma ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Stimulating Factor

scholarly journals Granulocyte-colony stimulating factor (G-CSF) producing malignant pleural mesothelioma: Report of a case

2015 ◽  
Vol 6 (1) ◽  
pp. 105-109 ◽  
Author(s):  
Ayako Fujiwara ◽  
Masahiko Higashiyama ◽  
Takashi Kanou ◽  
Jiro Okami ◽  
Toshiteru Tokunaga ◽  
...  
Keyword(s):  
Malignant Pleural Mesothelioma ◽  
Pleural Mesothelioma ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Stimulating Factor ◽  
Factor G

Malignant Pleural Mesothelioma Produces Functional Granulocyte-Colony Stimulating Factor

CHEST Journal ◽  
2001 ◽  
Vol 119 (3) ◽  
pp. 981-983 ◽  
Author(s):  
Ikuma Kasuga ◽  
Shirou Ishizuka ◽  
Kazushige Minemura ◽  
Kenta Utsumi ◽  
Kazuma Ohyashiki ◽  
...  
Keyword(s):  
Malignant Pleural Mesothelioma ◽  
Pleural Mesothelioma ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Stimulating Factor

scholarly journals Granulocyte colony-stimulating factor- and chemotherapy-induced large-vessel vasculitis: six patient cases and a systematic literature review

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Kirsi Taimen ◽  
Samu Heino ◽  
Ia Kohonen ◽  
Heikki Relas ◽  
Riikka Huovinen ◽  
...  
Keyword(s):  
Adverse Event ◽  
Literature Review ◽  
Systematic Literature Review ◽  
Case Reports ◽  
Large Vessel Vasculitis ◽  
Large Vessel ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Drug Induced ◽  
Stimulating Factor

Abstract Objective Patients receiving chemotherapy are prone to neutropoenic infections, presenting with non-specific symptoms such as a high fever and elevated inflammatory parameters. Large-vessel vasculitis (LVV) may have a similar clinical presentation and should be included in differential diagnostics. A few published case reports and adverse event reports suggest a causal association between LVV and the use of granulocyte colony-stimulating factor (G-CSF) and chemotherapy. Our objective was to evaluate the relationship between LVV, G-CSF and chemotherapy. Methods Between 2016 and 2018, we identified six patients in Finland with probable drug-induced LVV associated with G-CSF and chemotherapy. All six patients had breast cancer. A systematic literature review was performed according to PRISMA guidelines using comprehensive search terms for cancer, chemotherapy, G-CSF and LVV. Results The literature search identified 18 similar published case reports, of which most were published after 2014. In all patients combined (n = 24), the time delay from the last drug administration to the LVV symptoms was on average 5 days with G-CSF (range = 1–8 days) and 9 days with chemotherapy (range = 1–21 days). Common symptoms were fever (88%), neck pain (50%) and chest pain (42%). Based on imaging, 17/24 (71%) had vascular inflammation in the thoracic aorta and supra-aortic vessels, but 5/24 (21%) reportedly had inflammation limited to the carotid area. Conclusion This review suggests that LVV may be a possible serious adverse event associated with G-CSF and chemotherapy. Successful management of drug-induced LVV requires early identification, through diagnostic imaging, and discontinuation of the drug.

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