RESPONSE TO OMALIZUMAB TREATMENT ACCORDING TO PRE-TREATMENT BLOOD EOSINOPHIL COUNT: RESULTS OF A FRENCH REAL-WORLD STUDY (STELLAIR)

Respirology ◽  
2017 ◽  
Vol 22 ◽  
pp. 169-169
Keyword(s):  
Real World ◽  
Eosinophil Count ◽  
Blood Eosinophil ◽  
Blood Eosinophil Count ◽  
Pre Treatment

scholarly journals Is Blood Eosinophil Count a Biomarker for Chronic Obstructive Pulmonary Disease in a Real-World Clinical Setting? Predictive Property and Longitudinal Stability in Japanese Patients

Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 404
Author(s):  
Koichi Nishimura ◽  
Masaaki Kusunose ◽  
Ryo Sanda ◽  
Mio Mori ◽  
Ayumi Shibayama ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Real World ◽  
Clinical Setting ◽  
Eosinophil Count ◽  
Chronic Obstructive ◽  
Blood Eosinophil ◽  
Longitudinal Stability ◽  
Obstructive Pulmonary Disease ◽  
Blood Eosinophil Count

The authors examined predictive properties and the longitudinal stability of blood eosinophil count (BEC) or three strata (<100 cells/mm3, 100–299 cells/mm3 and ≥300 cells/mm3) in patients with chronic obstructive pulmonary disease (COPD) for up to six and a half years as part of a hospital-based cohort study. Of the 135 patients enrolled, 21 (15.6%) were confirmed to have died during the follow-up period. Episodes of acute exacerbation of COPD (AECOPD) were identified in 74 out of 130 available patients (56.9%), and admission due to AECOPD in 35 out of 132 (26.5%). Univariate Cox proportional hazards analyses revealed that almost all the age, forced expiratory volume in 1 s (FEV1) and health status measures using St. George’s Respiratory Questionnaire (SGRQ) Total and COPD Assessment Test (CAT) Score were significantly related to these types of events, but the relationship between age and AECOPD did not reach statistical significance (p = 0.05). Neither BEC nor the three different groups stratified by BEC were significant predictors of any subsequent events. There were no significant differences in the BEC between Visits 1–3 (p = 0.127, Friedman test). The ICC value was 0.755 using log-transformed data, indicating excellent repeatability. In the case of assigning to strata, Fleiss’ kappa was calculated to be 0.464, indicating moderate agreement. The predictive properties of BEC may be limited in a real-world Japanese clinical setting. Attention must be paid to the fact that the longitudinal stability of the three strata is regarded as moderate.

Point-of-care blood eosinophil count in a severe asthma clinic setting

2017 ◽  
Vol 119 (1) ◽  
pp. 16-20 ◽  
Author(s):  
Enrico Heffler ◽  
Giovanni Terranova ◽  
Carlo Chessari ◽  
Valentina Frazzetto ◽  
Claudia Crimi ◽  
...  
Keyword(s):  
Severe Asthma ◽  
Eosinophil Count ◽  
Point Of Care ◽  
Blood Eosinophil ◽  
Blood Eosinophil Count ◽  
Clinic Setting

scholarly journals Blood eosinophil count to predict bronchial eosinophilic inflammation in COPD

2016 ◽  
Vol 47 (5) ◽  
pp. 1562-1564 ◽  
Author(s):  
Florence Schleich ◽  
Jean-Louis Corhay ◽  
Renaud Louis
Keyword(s):  
Eosinophil Count ◽  
Blood Eosinophil ◽  
Eosinophilic Inflammation ◽  
Blood Eosinophil Count
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