A FINE PARTICLE INHALED CORTICOSTEROID EXHALATION THOUGH THE NOSE IS A THERAPEUTIC OPTION FOR EOSINOPHILIC CHRONIC RHINOSINUSITIS WITH BRONCHIAL ASTHMA

Respirology ◽  
2017 ◽  
Vol 22 ◽  
pp. 168-168
Keyword(s):  
Chronic Rhinosinusitis ◽  
Bronchial Asthma ◽  
Fine Particle ◽  
Therapeutic Option ◽  
Inhaled Corticosteroid ◽  
Eosinophilic Chronic Rhinosinusitis

scholarly journals Omalizumab Restores Response to Corticosteroids in Patients with Eosinophilic Chronic Rhinosinusitis and Severe Asthma

Biomedicines ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 787
Author(s):  
Yoshiki Kobayashi ◽  
Akira Kanda ◽  
Dan Van Bui ◽  
Yasutaka Yun ◽  
Linh Manh Nguyen ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Chronic Rhinosinusitis ◽  
Severe Asthma ◽  
Treatment Effectiveness ◽  
Therapeutic Option ◽  
Real Life ◽  
Sinus Surgery ◽  
Global Evaluation ◽  
Corticosteroid Resistance ◽  
Eosinophilic Chronic Rhinosinusitis

Eosinophilic chronic rhinosinusitis (ECRS), which is a subgroup of chronic rhinosinusitis with nasal polyps, is characterized by eosinophilic airway inflammation extending across both the upper and lower airways. Some severe cases are refractory even after endoscopic sinus surgery, likely because of local steroid insensitivity. Although real-life studies indicate that treatment with omalizumab for severe allergic asthma improves the outcome of coexistent ECRS, the underlying mechanisms of omalizumab in eosinophilic airway inflammation have not been fully elucidated. Twenty-five patients with ECRS and severe asthma who were refractory to conventional treatments and who received omalizumab were evaluated. Nineteen of twenty-five patients were responsive to omalizumab according to physician-assessed global evaluation of treatment effectiveness. In the responders, the levels of peripheral blood eosinophils and fractionated exhaled nitric oxide (a marker of eosinophilic inflammation) and of CCL4 and soluble CD69 (markers of eosinophil activation) were reduced concomitantly with the restoration of corticosteroid sensitivity. Omalizumab restored the eosinophil-peroxidase-mediated PP2A inactivation and steroid insensitivity in BEAS-2B. In addition, the local inflammation simulant model using BEAS-2B cells incubated with diluted serum from each patient confirmed omalizumab’s effects on restoration of corticosteroid sensitivity via PP2A activation; thus, omalizumab could be a promising therapeutic option for refractory eosinophilic airway inflammation with corticosteroid resistance.

Replacement of SFC-DPI with SFC-MDI exhaled through the nose improved eosinophilic chronic rhinosinusitis with bronchial asthma

2017 ◽  
Vol 55 (01) ◽  
pp. 89-94 ◽  
Author(s):  
Yoshiki Kobayashi ◽  
Mikiya Asako ◽  
Takahisa Yamamoto ◽  
Hirotaka Yasuba ◽  
Koichi Tomoda ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Bronchial Asthma ◽  
Eosinophilic Chronic Rhinosinusitis

Clinical Characteristics and Expression of Thymic Stromal Lymphopoetin in Eosinophilic and Non-Eosinophilic Chronic Rhinosinusitis

ORL ◽  
2013 ◽  
Vol 75 (1) ◽  
pp. 37-45 ◽  
Author(s):  
Yuhui Ouyang ◽  
Erzhong Fan ◽  
Ying Li ◽  
Xiangdong Wang ◽  
Luo Zhang
Keyword(s):  
Chronic Rhinosinusitis ◽  
Clinical Characteristics ◽  
Eosinophilic Chronic Rhinosinusitis

scholarly journals A Case of IgG4-Related Disease with Bronchial Asthma and Chronic Rhinosinusitis in Korea

2014 ◽  
Vol 29 (4) ◽  
pp. 599 ◽  
Author(s):  
Young-Soo Lee ◽  
Hyo-Jeong Cho ◽  
Hye-Soo Yoo ◽  
Yoo-Sub Shin ◽  
Hae-Sim Park
Keyword(s):  
Chronic Rhinosinusitis ◽  
Bronchial Asthma ◽  
Related Disease ◽  
Igg4 Related Disease

scholarly journals Efficacy and use of benralizumab in patients with eosinophilic chronic rhinosinusitis

2021 ◽  
Vol 18 ◽  
pp. 100257
Author(s):  
G.L. Fadda ◽  
A. Galizia ◽  
P. Galizia ◽  
L. Maugeri ◽  
C. Alati ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Eosinophilic Chronic Rhinosinusitis

scholarly journals A case of eosinophilic chronic rhinosinusitis associated with optic neuropathy

2011 ◽  
pp. 853 ◽  
Author(s):  
Takuji Kurimoto ◽  
Masahiro Tonari ◽  
Norihiko Ishizaki ◽  
Junko Matsuo ◽  
Hidehiro Oku ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Optic Neuropathy ◽  
Eosinophilic Chronic Rhinosinusitis

scholarly journals A Global Analysis of Tandem 3′UTRs in Eosinophilic Chronic Rhinosinusitis with Nasal Polyps

PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e48997 ◽  
Author(s):  
Peng Tian ◽  
Yu Sun ◽  
Yuxin Li ◽  
Xiang Liu ◽  
Liang Wan ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Nasal Polyps ◽  
Global Analysis ◽  
Eosinophilic Chronic Rhinosinusitis
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