THE ROLE OF MITOCHONDRIAL FUSION IN THE PATHOGENESIS OF SEVERE ASTHMA WITH FUNGAL SENSITIZATION

Respirology ◽  
2017 ◽  
Vol 22 ◽  
pp. 82-82
Keyword(s):  
Severe Asthma ◽  
Mitochondrial Fusion ◽  
Fungal Sensitization

scholarly journals Fungal sensitization of patients with asthma in St. Petersburg

2015 ◽  
Vol 12 (5) ◽  
pp. 3-8
Author(s):  
Y I Kozlova ◽  
E V Frolova ◽  
A V Sobolev ◽  
O V Aak ◽  
A E Uchevatkina ◽  
...  
Keyword(s):  
Severe Asthma ◽  
Asthma Severity ◽  
Th2 Cells ◽  
Course Of Disease ◽  
Fungal Allergens ◽  
Asthma Patients ◽  
Serum Total Ige ◽  
Fungal Sensitization

Background. Fungal sensitization is associated with severe uncontrolled asthma. Connections of specific, micromycetes and fungal allergens with disease development and immunopathogenesis of asthma with fungal sensitization are not well understood. Methods. The study included 120 patients with different grades of asthma severity. Results. Fungal sensitization was detected in 48 patients with asthma (40%). Severe course of asthma with fungal sensitization was identified in 7 patients (14,6%). The main fungal allergens in patients with severe asthma were Alternaria spp. and Aspergillus spp., in patients with mild and moderate course of disease - Aspergillus spp. and Penicillium spp. Increasing of serum total IgE and enhancing the ability of blood cells to produce IL2 and IFN-y in patients with bronchial asthma with fungal sensitization were revealed. The obtained results indicated the important role of Th1 along with Th2 cells in the development of immunopathological process in asthma patients withfungal sensitization. Conclusion. Further research is necessary for determination of clinical and immunological criteria of severe asthma with fungal sensitization and study of the effectiveness of antimycotic therapy.

Mitochondrial fusion in the pathogenesis of severe asthma with fungal sensitization

2016 ◽  
Author(s):  
So Ri Kim ◽  
Yong Chul Lee ◽  
Hae Jin Park ◽  
Dong Im Kim ◽  
Soon Ha Kim
Keyword(s):  
Severe Asthma ◽  
Mitochondrial Fusion ◽  
Fungal Sensitization

scholarly journals Genetic susceptibility to severe asthma with fungal sensitization

2017 ◽  
Vol 44 (3) ◽  
pp. 93-106 ◽  
Author(s):  
N. L. Overton ◽  
A. Simpson ◽  
P. Bowyer ◽  
D. W. Denning
Keyword(s):  
Genetic Susceptibility ◽  
Severe Asthma ◽  
Fungal Sensitization

The role of systemic corticosteroids in severe asthma and new evidence in their management and tapering

2021 ◽  
Author(s):  
Francesco Menzella ◽  
Giulia Ghidoni ◽  
Matteo Fontana ◽  
Silvia Capobelli ◽  
Francesco Livrieri ◽  
...  
Keyword(s):  
Severe Asthma ◽  
Systemic Corticosteroids ◽  
New Evidence

CHIT1 Mutations: Genetic Risk Factor for Severe Asthma With Fungal Sensitization?

PEDIATRICS ◽  
2010 ◽  
Vol 126 (4) ◽  
pp. e982-e985 ◽  
Author(s):  
A. G. Vicencio ◽  
G. L. Chupp ◽  
K. Tsirilakis ◽  
X. He ◽  
A. Kessel ◽  
...  
Keyword(s):  
Risk Factor ◽  
Severe Asthma ◽  
Genetic Risk ◽  
Genetic Risk Factor ◽  
Fungal Sensitization

scholarly journals Pharmacological Rationale for Targeting IL-17 in Asthma

2021 ◽  
Vol 2 ◽  
Author(s):  
Siti Farah Rahmawati ◽  
Maurice te Velde ◽  
Huib A. M. Kerstjens ◽  
Alexander S. S. Dömling ◽  
Matthew Robert Groves ◽  
...  
Keyword(s):  
Severe Asthma ◽  
Inhaled Corticosteroids ◽  
Current Knowledge ◽  
Experimental Models ◽  
Airflow Limitation ◽  
Interleukin 17 ◽  
Asthma Phenotype ◽  
T Helper 2 ◽  
Bronchial Biopsies

Asthma is a respiratory disease that currently affects around 300 million people worldwide and is defined by coughing, shortness of breath, wheezing, mucus overproduction, chest tightness, and expiratory airflow limitation. Increased levels of interleukin 17 (IL-17) have been observed in sputum, nasal and bronchial biopsies, and serum of patients with asthma compared to healthy controls. Patients with higher levels of IL-17 have a more severe asthma phenotype. Biologics are available for T helper 2 (Th2)-high asthmatics, but the Th17-high subpopulation has a relatively low response to these treatments, rendering it a rather severe asthma phenotype to treat. Several experimental models suggest that targeting the IL-17 pathway may be beneficial in asthma. Moreover, as increased activation of the Th17/IL-17 axis is correlated with reduced inhaled corticosteroids (ICS) sensitivity, targeting the IL-17 pathway might reverse ICS unresponsiveness. In this review, we present and discuss the current knowledge on the role of IL-17 in asthma and its interaction with the Th2 pathway, focusing on the rationale for therapeutic targeting of the IL-17 pathway.

scholarly journals Severe eosinophilic bronchial asthma: new therapeutic options

2018 ◽  
pp. 44-52 ◽  
Author(s):  
N. M. Nenasheva
Keyword(s):  
Monoclonal Antibodies ◽  
Severe Asthma ◽  
Bronchial Asthma ◽  
Biological Agents ◽  
Therapeutic Options ◽  
Clinical Use ◽  
Eosinophilic Asthma ◽  
Interleukin 5 ◽  
Severe Eosinophilic Asthma

Eosinophilic asthma is a common phenotype of severe asthma, occurring in at least half of patients. In recent years, there have been significant changes in the approaches to the treatment of severe bronchial asthma and, above all, eosinophilic asthma. The article discusses the role of eosinophils in the pathogenesis of severe asthma, the detection of the phenotype of severe eosinophilic asthma, and modern approaches to targeting severe asthma with an eosinophilic phenotype using biological agents. A special emphasis is placed on preparations of monoclonal antibodies to interleukin-5, in particular, mepolizumab, recently approved for clinical use in our country.

scholarly journals The role of the TGF-SMAD signalling pathway in the etiopathogenesis of severe asthma

2016 ◽  
Vol 84 (5) ◽  
pp. 290-301 ◽  
Author(s):  
Marcelina Koćwin ◽  
Mateusz Jonakowski ◽  
Marcelina Przemęcka ◽  
Jan Zioło ◽  
Michał Panek ◽  
...  
Keyword(s):  
Severe Asthma ◽  
Signalling Pathway
Sign in / Sign up

Export Citation Format

Share Document