Subgroup analysis of Asian patients in the INPULSIS®trials of nintedanib in idiopathic pulmonary fibrosis

Respirology ◽  
2016 ◽  
Vol 21 (8) ◽  
pp. 1425-1430 ◽  
Author(s):  
Hiroyuki Taniguchi ◽  
Zuojun Xu ◽  
Arata Azuma ◽  
Yoshikazu Inoue ◽  
Huiping Li ◽  
...  
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Subgroup Analysis ◽  
Asian Patients

scholarly journals Nintedanib in Japanese patients with idiopathic pulmonary fibrosis: A subgroup analysis of the INPULSIS® randomized trials

Respirology ◽  
2016 ◽  
Vol 22 (4) ◽  
pp. 750-757 ◽  
Author(s):  
Arata Azuma ◽  
Hiroyuki Taniguchi ◽  
Yoshikazu Inoue ◽  
Yasuhiro Kondoh ◽  
Takashi Ogura ◽  
...  
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Subgroup Analysis ◽  
Randomized Trials ◽  
Japanese Patients

Subgroup Analysis for Chinese Patients Included in the INPULSIS® Trials on Nintedanib in Idiopathic Pulmonary Fibrosis

2019 ◽  
Vol 36 (3) ◽  
pp. 621-631 ◽  
Author(s):  
Zuojun Xu ◽  
Huiping Li ◽  
Fuqiang Wen ◽  
Chunxue Bai ◽  
Ping Chen ◽  
...  
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Subgroup Analysis ◽  
Chinese Patients

scholarly journals Long‐term treatment with nintedanib in Asian patients with idiopathic pulmonary fibrosis: Results from INPULSIS®‐ON

Respirology ◽  
2019 ◽  
Vol 25 (4) ◽  
pp. 410-416 ◽  
Author(s):  
Jin Woo Song ◽  
Takashi Ogura ◽  
Yoshikazu Inoue ◽  
Zuojun Xu ◽  
Manuel Quaresma ◽  
...  
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Term Treatment ◽  
Asian Patients ◽  
Long Term Treatment

scholarly journals Prognostic Value of Cardiopulmonary Exercise Test, Pulmonary Function Test , and Questionnaires on Mortality in Patients With Idiopathic Pulmonary Fibrosis: A Prospective Pilot Study

2020 ◽  
Author(s):  
Yuan-Yang Cheng ◽  
Shih-Yi Lin ◽  
Shin-Tsu Chang ◽  
Chu-Hsing Lin ◽  
Pin-Kuei Fu
Keyword(s):  
Body Weight ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Pulmonary Function ◽  
Prognostic Value ◽  
Vital Capacity ◽  
Cardiopulmonary Exercise Test ◽  
Cardiopulmonary Exercise ◽  
Asian Patients ◽  
Function Test

Abstract Background and Objective: Idiopathic pulmonary fibrosis (IPF) is a lung disease with a high mortality rate. Finding an effective predictor of survival is therefore important for clinicians and patients. Several parameters have been established to predict mortality, but none of these have been validated in the Asian population. In this study, we evaluated the prognostic value of the parameters of cardiopulmonary exercise test (CPET), pulmonary function test (PFT), 6-min walk test (6MWT), and certain questionnaires on mortality in Asian patients with IPF. Methods: This prospective observational study analysed patient data, including age, gender, height, and body weight; scores of Saint George’s Respiratory Questionnaire (SGRQ), Modified Medical Research Council (mMRC) for dyspnoea, and Short Form-36 (SF-36); and parameters of PFT, 6MWT, and CPET. Results: In total, 24 patients diagnosed as having IPF were followed up for 14 months, during which 3 patients died. The nonsurvivors had significantly lower body weight; lower forced vital capacity (FVC); higher ratio of forced expiratory volume in 1 s to forced vital capacity (FEV1/FVC); higher gender, age, and pulmonary physiology (GAP) index; shorter walk distance in 6MWT; lower end-tidal pressure of carbon dioxide (DLCO); higher functional aerobic impairment (FAI) during exercise; and higher mMRC score. FEV1/FVC, FAI, GAP index, and mMRC dyspnoea score demonstrated an area under curve (AUC) of >0.7, and the corresponding cut-off values were 89%, 54%, 7, and 3. Conclusions: The predictive abilities of PFT, CPET, and mMRC scores were validated successfully in the study cohort of Asian patients with IPF.

scholarly journals Idiopathic Pulmonary Fibrosis and Diabetes Mellitus: A Meta-Analysis and Systematic Review

2021 ◽  
Author(s):  
Le Bai ◽  
Li Zhang ◽  
Tingyu Pan ◽  
Wei Wang ◽  
Dian Wang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Subgroup Analysis ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Case Control Studies ◽  
China National Knowledge Infrastructure ◽  
Bias Analysis ◽  
Meta Regression

Abstract Background: Idiopathic pulmonary fibrosis (IPF) is a chronic diffuse interstitial lung disease, of which the etiology has been poorly understood. Several studies have focused on the relationship between IPF and diabetes mellitus (DM) in the past years but have failed to reach a consensus. This meta-analysis aimed to examine the association between diabetes to IPF.Methods: We accumulated studies investigating the association between DM and IPF from databases including Medline, Cochrane Library, Embase, Web of Science, and China National Knowledge Infrastructure. RevMan 5.3 and the Newcastle-Ottawa Scale (NOS) were utilized to analyze the data and assess the quality of the included studies. The value of odds ratio (OR) with 95% confidence interval (CI) was used as the measure to estimate the risk of DM in IPF. Heterogeneity was assessed by I2 statistics. We also performed subgroup analysis, meta-regression, and Egger’s test for bias analysis. Results: Nine case-control studies with 5,096 IPF patients and 19,095 control subjects were included in the present meta-analysis, which indicated that DM could increase the risk of IPF (OR: 1.65, 95% CI: 1.30-2.10; P < 0.0001). Meta-regression and subgroup analysis negated the influence of covariates like cigarette smoking, age and gender, but the heterogeneity existed and could not be fully explained. Conclusion: The meta-analysis indicated that DM is highly probably related to IPF. Further rigorously designed studies are required to confirm the present findings and investigate the possible mechanisms behind the effect of DM on IPF.

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