scholarly journals Effect of long-term treatment with corticosteroids on skeletal muscle strength, functional exercise capacity and health status in patients with interstitial lung disease

Respirology ◽  
2016 ◽  
Vol 21 (6) ◽  
pp. 1088-1093 ◽  
Author(s):  
Masatoshi Hanada ◽  
Noriho Sakamoto ◽  
Yuji Ishimatsu ◽  
Tomoyuki Kakugawa ◽  
Yasushi Obase ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Health Status ◽  
Interstitial Lung Disease ◽  
Muscle Strength ◽  
Term Treatment ◽  
Long Term Treatment ◽  
Functional Exercise ◽  
Functional Exercise Capacity ◽  
Skeletal Muscle Strength

Long-term Enrollment in Cardiac Rehabilitation Benefits Cardiorespiratory Fitness and Skeletal Muscle Strength in Men With Cardiovascular Disease

2019 ◽  
Vol 35 (10) ◽  
pp. 1359-1365 ◽  
Author(s):  
Mike Pryzbek ◽  
Maureen MacDonald ◽  
Paul Stratford ◽  
Angelica McQuarrie ◽  
Julie Richardson ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Skeletal Muscle ◽  
Muscle Strength ◽  
Cardiac Rehabilitation ◽  
Cardiorespiratory Fitness ◽  
Skeletal Muscle Strength

The Long-term Treatment of Multifocal Motor Neuropathy with Intravenous Immunoglobulin

2012 ◽  
Vol 7 (2) ◽  
pp. 128 ◽  
Author(s):  
Leonard H van den Berg ◽  
Keyword(s):  
Muscle Strength ◽  
Intravenous Immunoglobulin ◽  
Initial Response ◽  
Multifocal Motor Neuropathy ◽  
Term Treatment ◽  
Response To Treatment ◽  
Motor Neuropathy ◽  
Double Blind ◽  
Long Term Treatment

Multifocal motor neuropathy (MMN) is a rare, purely motor neuropathy. It is a progressive disorder, most patients eventually developing severe fatigue and weakness in the arm muscles that severely impair daily functioning and quality of life. Unlike other motor neuropathies such as motor neurone disease, MMN is treatable with regular infusions of intravenous immunoglobulin (IVIg). Four double-blind, randomised, placebo-controlled studies have shown that in the short term, IVIg significantly improves muscle strength and disability in more than 70 % of patients. The 11 observational studies reviewed in this article confirm that long-term maintenance treatment with IVIg maintains clinical improvement compared to pre-treatment baseline in most patients. Infusions are generally well tolerated, but regular monitoring and re-evaluation of the IVIg maintenance regimen is essential, as most patients need progressive increases in dosage or reduced intervals between infusions to maintain their response to treatment. In the absence of accepted predictive markers, maintenance IVIg should be individualised, based on each patient’s initial response, disability and the interval between the first infusion and decline in muscle strength.

scholarly journals Dermal papillae flattening of thigh skin in Conus Cauda Syndrome

2018 ◽  
Vol 28 (4) ◽  
Author(s):  
Barbara Ravara ◽  
Christian Hofer ◽  
Helmut Kern ◽  
Diego Guidolin ◽  
Andrea Porzionato ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Cauda Equina ◽  
Term Treatment ◽  
Elastic Fibers ◽  
Quantitative Evidence ◽  
Thigh Muscles ◽  
Long Term Treatment ◽  
Cord Injury ◽  
Skin Biopsies

Our previous studies have shown that severely atrophic Quadriceps muscles of spinal cord injury (SCI) persons suffering with complete conus and cauda equina syndrome, and thus with permanent denervation-induced atrophy and degeneration of muscle, were almost completely rescued to normal size after two years of home based Functional Electrical Stimulation (hbFES). Since large surface electrodes were used to stimulate the denervated thigh muscles, we wanted to know if the skin was affected by this peculiar long-term treatment. Indeed, we demonstrated by two approaches that the epidermis decreases in thickness in the long term denervated persons, while it increased to almost pre-SCI values in hbFES compliant SCI persons. Here we report data of morphometry of skin biopsies from both legs of 18 SCI persons, harvested at enrolment in the Project RISE, to test if the Interdigitation Index, a simple measurement of the epidermal‐dermal junction, may provide a further precise quantitative evidence of the flattening of the skin in those SCI persons. The Interdigitation Index of the 36 skin biopsies shows a higly significant linear correlation with the years of SCI (p < 0.001). Furthermore, when the 18 SCI persons are divided in two groups (1 to 3.9 versus 4.1 to 8.0 years from SCI, respectively) and the data are compared, the later Group presents a statistically significant -22% decrease (p, 0.029) of the Interdigitation Index. On the other hand counting the papille do not provide the same strong evidence. In conclusion, the Interdigitation Index is an additional sound quantitative structural biomarker of skin atrophy and flattening occurring in SCI. The result correlates with the much severe extent of atrophy of the permanently denervated thigh muscles, as determined at both macro and microscopic levels.We are confident that the Interdigitation Index will provide sound evidence that the effects of hbFES, we previously reported on skeletal muscle and epidermis thickness, will be extended to the dermal layer of the skin, suggesting a coordinated negative effects of SCI on skeletal muscle and skin, and an improvement of both tissues after hbFES. Incoming analyses will be extended to basal lamina, collagene types, elastic fibers and skin annexes in the subcutaneous layer.

scholarly journals Long-term treatment with human immunoglobulin for antisynthetase syndrome-associated interstitial lung disease

2019 ◽  
Vol 154 ◽  
pp. 6-11 ◽  
Author(s):  
J.A. Huapaya ◽  
R. Hallowell ◽  
L. Silhan ◽  
I. Pinal-Fernandez ◽  
M. Casal-Dominguez ◽  
...  
Keyword(s):  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Term Treatment ◽  
Human Immunoglobulin ◽  
Antisynthetase Syndrome ◽  
Long Term Treatment

scholarly journals Long-Term Enrollment in Cardiac Rehabilitation Benefits of Cardiorespiratory Fitness and Skeletal Muscle Strength in Females with Cardiovascular Disease

2021 ◽  
Vol 2 (1) ◽  
pp. 543-549
Author(s):  
Mike Pryzbek ◽  
Maureen MacDonald ◽  
Paul Stratford ◽  
Julie Richardson ◽  
Angelica McQuarrie ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Skeletal Muscle ◽  
Muscle Strength ◽  
Cardiac Rehabilitation ◽  
Cardiorespiratory Fitness ◽  
Skeletal Muscle Strength
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