Comparison of innate immune responses towards rhinovirus infection of primary nasal and bronchial epithelial cells

Respirology ◽  
2015 ◽  
Vol 21 (2) ◽  
pp. 304-312 ◽  
Author(s):  
Marco P. Alves ◽  
Aline Schögler ◽  
Simone Ebener ◽  
Nathalie J. Vielle ◽  
Carmen Casaulta ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Immune Responses ◽  
Bronchial Epithelial Cells ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Bronchial Epithelial ◽  
Rhinovirus Infection

Carbocysteine regulates innate immune responses and senescence processes in cigarette smoke stimulated bronchial epithelial cells

2013 ◽  
Vol 223 (2) ◽  
pp. 198-204 ◽  
Author(s):  
Elisabetta Pace ◽  
Maria Ferraro ◽  
Liboria Siena ◽  
Valeria Scafidi ◽  
Stefania Gerbino ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Immune Responses ◽  
Cigarette Smoke ◽  
Bronchial Epithelial Cells ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Bronchial Epithelial

scholarly journals Pseudomonas aeruginosa Suppresses Interferon Response to Rhinovirus Infection in Cystic Fibrosis but Not in Normal Bronchial Epithelial Cells

2011 ◽  
Vol 79 (10) ◽  
pp. 4131-4145 ◽  
Author(s):  
Sangbrita S. Chattoraj ◽  
Shyamala Ganesan ◽  
Andrea Faris ◽  
Adam Comstock ◽  
Wai-Ming Lee ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Immune Responses ◽  
Bronchial Epithelial Cells ◽  
Innate Immune ◽  
Interferon Response ◽  
Innate Immune Responses ◽  
Normal Cells ◽  
Bronchial Epithelial ◽  
Content Type ◽  
Infected Cells

ABSTRACTDespite increased morbidity associated with secondary respiratory viral infections in cystic fibrosis (CF) patients with chronicPseudomonas aeruginosainfection, the underlying mechanisms are not well understood. Here, we investigated the effect ofP. aeruginosainfection on the innate immune responses of bronchial epithelial cells to rhinovirus (RV) infection. CF cells sequentially infected with mucoidP. aeruginosa(MPA) and RV showed lower levels of interferons (IFNs) and higher viral loads than those of RV-infected cells. Unlike results for CF cells, normal bronchial epithelial cells coinfected with MPA/RV showed higher IFN expression than RV-infected cells. In both CF and normal cells, the RV-stimulated IFN response requires phosphorylation of Akt and interferon response factor 3 (IRF3). Preinfection with MPA inhibited RV-stimulated Akt phosphorylation and decreased IRF3 phosphorylation in CF cells but not in normal cells. Compared to normal, unstimulated CF cells or normal cells treated with CFTR inhibitor showed increased reactive oxygen species (ROS) production. Treatment of CF cells with antioxidants prior to MPA infection partially reversed the suppressive effect of MPA on the RV-stimulated IFN response. Together, these results suggest that MPA preinfection inhibits viral clearance by suppressing the antiviral response particularly in CF cells but not in normal cells. Further, increased oxidative stress in CF cells appears to modulate the innate immune responses to coinfection.

Flagellin induces innate immune genes in bronchial epithelial cells in vivo: Role of TET2

2021 ◽  
Author(s):  
Wanhai Qin ◽  
Xanthe Brands ◽  
Cornelis Veer ◽  
Alex F. Vos ◽  
Brendon P. Scicluna ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Bronchial Epithelial Cells ◽  
Innate Immune ◽  
Bronchial Epithelial ◽  
Immune Genes ◽  
Innate Immune Genes
Sign in / Sign up

Export Citation Format

Share Document