scholarly journals To eliminate tuberculosis, we must universally encourage treatment of its latent form

Respirology ◽  
2015 ◽  
Vol 21 (2) ◽  
pp. 396-396
Author(s):  
Anastasios Konstantinos
Keyword(s):  
Latent Form

Latent form of multiple dermoid cysts in the jaw bone

2003 ◽  
Vol 53 (11) ◽  
pp. 786-789 ◽  
Author(s):  
Yasunori Takeda ◽  
Yuko Oikawa ◽  
Masanobu Satoh ◽  
Shin-ichi Nakamura
Keyword(s):  
Latent Form ◽  
Jaw Bone

scholarly journals Megacities in climate governance: the case of Rio de Janeiro

2016 ◽  
Vol 17 ◽  
Author(s):  
Alberto Teixeira Da Silva ◽  
Mercedes Pardo Buendía
Keyword(s):  
Technological Innovation ◽  
Rio De Janeiro ◽  
Vital Role ◽  
Environmental Risks ◽  
Climate Governance ◽  
Latent Form ◽  
Domestic Policies ◽  
Social Empowerment

This paper shows the vital role of cities in climate governance, as places where the crisis is expressed in latent form, but also as emblematic spaces in terms of technological innovation and social empowerment. It discusses challenges of megacities like Rio de Janeiro, given their vulnerability, resilience and environmental risks to the transition of a more intelligent and sustainable patterns of urbanization, through its domestic policies and paradiplomacy networks.Este artigo mostra o papel vital das cidades na governança do clima, como lugares onde a crise se expressa de forma latente, mas também como espaços emblemáticos em termos de inovação tecnológica e empoderamento social. Discute os desafios de megacidades como Rio de Janeiro, considerando suas vulnerabilidades, riscos socioambientais e resiliências para a transição de modelos mais inteligentes e sustentáveis de urbanização, através de suas políticas domésticas e redes de paradiplomacia. 

scholarly journals Conversion of the active to latent plasminogen activator inhibitor from human endothelial cells

Blood ◽  
1987 ◽  
Vol 70 (4) ◽  
pp. 1090-1098
Author(s):  
EG Levin ◽  
L Santell
Keyword(s):  
Endothelial Cells ◽  
Conditioned Medium ◽  
Plasminogen Activator ◽  
Active Form ◽  
Plasminogen Activator Inhibitor ◽  
Human Endothelial Cells ◽  
Inhibitor Activity ◽  
Latent Form ◽  
Activator Inhibitor ◽  
Pai 1

The plasminogen activator inhibitor from human endothelial cells (PAI- 1) exists in two forms in the culture medium: an active form that binds to and inactivates plasminogen activators and a latent form that in its native state has no anti-activator activity. Inhibitor activity associated with the latent form can be generated by treatment with protein denaturants and makes up more than 98% of the total inhibitor activity in conditioned medium. Plasminogen activator inhibitor activity is also found in cell cytosol. This inhibitor activity is stable to SDS-treatment but is not enhanced by it. We investigated the relationship between this active cell-associated inhibitor and the latent PAI-1 found in the conditioned medium. Both intracellular and extracellular inhibitors were immunoprecipitated by a monoclonal antibody produced against the latent inhibitor from HT1080 fibrosarcoma cells and electrophoresis on SDS gels of various acrylamide concentrations demonstrated that both forms had the same Mr. Incubation of cytosol inhibitor at 37 degrees C resulted in a decline in inhibitor activity with a half-life of approximately 4 hours, a rate of decline similar to that of the active PAI-1 in conditioned medium, with less than 10% of the original activity present after eight hours. This decline is accelerated at higher temperatures and is not affected by the presence of a variety of protease inhibitors. Approximately 90% of the activity can be regenerated after SDS treatment suggesting that the cell associated inhibitor, during incubation at 37 degrees C, converts to a form similar to that found in conditioned medium. Despite these similarities, the apparent Stoke's radii of the active intracellular inhibitor and the latent inhibitor in conditioned medium were significantly different with values of 2.77 nm and 2.40 nm for active and latent PAI-1, respectively. Incubation of the active form at 37 degrees C resulted in the shift of the Stoke's radius to that similar to the latent PAI-1 (2.45 nm). Thus, the active and latent PAI-1, while being immunologically similar and of the same apparent Mr, can be differentiated by their behavior on gel permeation columns. This suggests that the intracellular inhibitor is a precursor to the latent form.

About the hidden form of malaria

1927 ◽  
Vol 23 (1) ◽  
pp. 47-57
Author(s):  
G. S. Demyanov
Keyword(s):  
Microscopic Examination ◽  
Latent Form

Most of the authors who admit the existence of a latent form of malaria require the following conditions to prove it: 1) intermittency of seizures, 2) their rapid disappearance from quinine, and 3) signs of chronic malaria preceding or accompanying the disease, with Laveran considering microscopic examination of the blood the best means for diagnosis.

The case of comorbidity of sinus node dysfunction and new coronavirus infection with Sjogren’s disease and Thompson’s myotonia

2021 ◽  
Vol 25 (3) ◽  
pp. 35-40
Author(s):  
Maria O. Mohika Estepa ◽  
Nadezhda V. Muzhikina
Keyword(s):  
Respiratory System ◽  
Multidisciplinary Approach ◽  
Sinus Node ◽  
Cardiovascular Complications ◽  
Sinus Node Dysfunction ◽  
Therapeutic Approaches ◽  
Latent Form ◽  
Aged People ◽  
Coronavirus Infection ◽  
Sjögren’S Disease

Coronavirus infection, according to modern data, poses a threat not only to the respiratory system, in more than 15% of patients it can lead to cardiovascular complications, including in young and middle-aged people. COVID-19 is probably the trigger of a detailed clinical picture of chronic diseases occurring in a latent form. The article considers the case of sinus node dysfunction and polyneuropathy in a young patient after coronavirus infection against the background of concomitant diseases such as Sjogrens disease and Thompsons myotonia. To observe the dynamics of the three diseases, the timely organization of a multidisciplinary approach is important. It is necessary to consider all three diseases in the paradigm of the main and concomitant in order to timely and adequate therapy. Further study of the clinical features, therapeutic approaches and complications in patients with COVID-19 is required.

scholarly journals Quantitation and properties of the active and latent plasminogen activator inhibitors in cultures of human endothelial cells

Blood ◽  
1986 ◽  
Vol 67 (5) ◽  
pp. 1309-1313 ◽  
Author(s):  
EG Levin
Keyword(s):  
Endothelial Cells ◽  
Conditioned Medium ◽  
Plasminogen Activator ◽  
Active Form ◽  
Specific Inhibitor ◽  
Human Endothelial Cells ◽  
Inhibitor Activity ◽  
Active Inhibitor ◽  
Latent Form ◽  
Cell Extracts

Abstract Human endothelial cells release two forms of a plasminogen activator- specific inhibitor: an active form that readily binds to and inhibits plasminogen activators and an inactive or latent form that has no anti- activator activity but which can be activated by denaturation. Latent and active forms of plasminogen activator-specific inhibitor were measured in cultures of human umbilical vein endothelial cells. Latent inhibitor was activated by treatment with 1% sodium dodecyl sulfate (SDS), and both forms were assayed by the 125I-fibrin plate method. After 16 hours, the conditioned medium contained 104.6 U/mL latent inhibitor activity and 2.6 U/mL active inhibitor. The level of each form in the culture medium increased with time although the activity associated with the latent form rose more rapidly: the ratio of latent to active inhibitor activity was 12 at four hours (10.3 U/mL v 0.86 U/mL) and reached 56 at 24 hours (155.3 U/mL v 2.80 U/mL). Intracellular inhibitor activity was associated with the active form only; no additional inhibitor activity was observed following SDS treatment of cell extracts. A decline in active inhibitor activity occurred during incubation at 37 degrees C with a 50% reduction in activity occurring in two hours. Treatment of conditioned medium with 10 U/mL thrombin also resulted in a loss of active inhibitor activity. The latent inhibitor, however, was not affected by either of these conditions. The inhibitor activity lost during incubation at 37 degrees C or thrombin treatment could be regenerated by SDS treatment, suggesting that the loss of the active inhibitor activity represented a conversion of this form to its latent counterpart. Thus, the concentration, stability, and regulation of these two forms of plasminogen activator inhibitor in human endothelial cell cultures differ significantly.

scholarly journals Human cytomegalovirus persists in myeloid progenitors and is passed to the myeloid progeny in a latent form

2004 ◽  
Vol 126 (3) ◽  
pp. 410-417 ◽  
Author(s):  
Svetlana F. Khaiboullina ◽  
Jaroslaw P. Maciejewski ◽  
Kirsten Crapnell ◽  
Patricia A. Spallone ◽  
A. Dean Stock ◽  
...  
Keyword(s):  
Human Cytomegalovirus ◽  
Latent Form ◽  
Myeloid Progenitors

scholarly journals Guinea-pig liver tryptophan pyrrolase. Absence of detectable apoenzyme activity and of hormonal induction by cortisol and possible regulation by tryptophan

1974 ◽  
Vol 138 (3) ◽  
pp. 445-451 ◽  
Author(s):  
Abdulla A.-B. Badawy ◽  
Myrddin Evans
Keyword(s):  
Guinea Pig ◽  
Liver Enzyme ◽  
Guinea Pigs ◽  
Actinomycin D ◽  
The Other ◽  
Pig Liver ◽  
Latent Form ◽  
Tryptophan Pyrrolase ◽  
Guinea Pig Liver

1. When assayed in fresh homogenates, guinea-pig liver tryptophan pyrrolase exists only as holoenzyme. It does not respond to agents that activate or inhibit the rat liver enzyme in vitro. Only by aging (for 30min at 5°C) does the guinea-pig enzyme develop a requirement for ascorbate. 2. The guinea-pig liver enzyme is activated by the administration of tryptophan but not cortisol, salicylate, ethanol or 5-aminolaevulinate. 3. The tryptophan enhancement of the guinea-pig liver pyrrolase activity is prevented by 0, 34 and 86% by pretreatment with actinomycin D, cycloheximide or allopurinol respectively. 4. The guinea-pig liver tryptophan pyrrolase is more sensitive to tryptophan administration than is the rat enzyme. On the other hand, the concentrations of tryptophan in sera and livers of guinea pigs are 45–52% less than those in rats. 5. It is suggested that tryptophan may regulate the activity of guinea-pig liver tryptophan pyrrolase by mobilizing a latent form of the enzyme whose primary function is the detoxication of its substrate.

Sign in / Sign up

Export Citation Format

Share Document