Association between peripheral airway function and neutrophilic inflammation in asthma

Respirology ◽  
2015 ◽  
Vol 20 (6) ◽  
pp. 975-981 ◽  
Author(s):  
Claude S. Farah ◽  
Laurien A.B. Keulers ◽  
Kate M. Hardaker ◽  
Matthew J. Peters ◽  
Norbert Berend ◽  
...  
Keyword(s):  
Neutrophilic Inflammation ◽  
Airway Function ◽  
Peripheral Airway

Peripheral Airway Function Is Inversely Correlated With Mast Cell Density In A Sheep Model Of Chronic Asthma

2010 ◽  
Author(s):  
Joanne L. Van Der Velden ◽  
Donna Barker ◽  
Garry Barcham ◽  
Emmanuel Koumoundouros ◽  
Stuart Hirst ◽  
...  
Keyword(s):  
Mast Cell ◽  
Cell Density ◽  
Chronic Asthma ◽  
Sheep Model ◽  
Airway Function ◽  
Mast Cell Density ◽  
Peripheral Airway

scholarly journals Peripheral ventilation heterogeneity determines the extent of bronchoconstriction in asthma

2017 ◽  
Vol 123 (5) ◽  
pp. 1188-1194 ◽  
Author(s):  
Catherine E. Farrow ◽  
Cheryl M. Salome ◽  
Benjamin E. Harris ◽  
Dale L. Bailey ◽  
Norbert Berend ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Three Dimensional ◽  
Methacholine Challenge ◽  
Airway Narrowing ◽  
Nitrogen Washout ◽  
Airway Function ◽  
Ventilation Imaging ◽  
Before And After ◽  
Ventilation Heterogeneity ◽  
Peripheral Airway

In asthma, bronchoconstriction causes topographically heterogeneous airway narrowing, as measured by three-dimensional ventilation imaging. Computation modeling suggests that peripheral airway dysfunction is a potential determinant of acute airway narrowing measured by imaging. We hypothesized that the development of low-ventilation regions measured topographically by three-dimensional imaging after bronchoconstriction is predicted by peripheral airway function. Fourteen asthmatic subjects underwent ventilation single-photon-emission computed tomography/computed tomography scan imaging before and after methacholine challenge. One-liter breaths of Technegas were inhaled from functional residual capacity in upright posture before supine scanning. The lung regions with the lowest ventilation (Ventlow) were calculated using a thresholding method and expressed as a percentage of total ventilation (Venttotal). Multiple-breath nitrogen washout was used to measure diffusion-dependent and convection-dependent ventilation heterogeneity (Sacin and Scond, respectively) and lung clearance index (LCI), before and after challenge. Forced expiratory volume in 1 s (FEV1) was 87.6 ± 15.8% predicted, and seven subjects had airway hyperresponsiveness. Ventlow at baseline was unrelated to spirometry or multiple-breath nitrogen washout indices. Methacholine challenge decreased FEV1 by 23 ± 5% of baseline while Ventlow increased from 21.5 ± 2.3%Venttotal to 26.3 ± 6.7%Venttotal ( P = 0.03). The change in Ventlow was predicted by baseline Sacin ( rs = 0.60, P = 0.03) and by LCI ( rs = 0.70, P = 0.006) but not by Scond ( rs = 0.30, P = 0.30). The development of low-ventilation lung units in three-dimensional ventilation imaging is predicted by ventilation heterogeneity in diffusion-dependent airways. This relationship suggests that acinar ventilation heterogeneity in asthma may be of mechanistic importance in terms of bronchoconstriction and airway narrowing. NEW & NOTEWORTHY Using ventilation SPECT/CT imaging in asthmatics, we show induced bronchoconstriction leads to the development of areas of low ventilation. Furthermore, the relative volume of the low-ventilation regions was predicted by ventilation heterogeneity in diffusion-dependent acinar airways. This suggests that the pattern of regional airway narrowing in asthma is determined by acinar airway function.

Peripheral airway function over time in children post bone marrow transplantation

2016 ◽  
Author(s):  
Rathnini Jayasuriya ◽  
Greg King ◽  
Hiran Selvadurai ◽  
Melissa Gabriel ◽  
Per Gustaffson ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Marrow Transplantation ◽  
Airway Function ◽  
Peripheral Airway ◽  
Over Time

Clinical applications of forced oscillation to assess peripheral airway function

2005 ◽  
Vol 148 (1-2) ◽  
pp. 179-194 ◽  
Author(s):  
Michael D. Goldman ◽  
Constantine Saadeh ◽  
David Ross
Keyword(s):  
Forced Oscillation ◽  
Clinical Applications ◽  
Airway Function ◽  
Peripheral Airway

Normal age-dependant changes in peripheral airway function in the elderly

2015 ◽  
Author(s):  
Christopher Htun ◽  
Samir Lahzami ◽  
Darren Luo ◽  
Robin Schoeffel ◽  
Gregory King
Keyword(s):  
The Elderly ◽  
Airway Function ◽  
Peripheral Airway

Peripheral airway function in healthy young cigarette smokers

Lung ◽  
1979 ◽  
Vol 156 (1) ◽  
pp. 205-215 ◽  
Author(s):  
G. N. Harrison ◽  
J. L. Mohler ◽  
L. A. Lewis ◽  
W. A. Speir
Keyword(s):  
Cigarette Smokers ◽  
Airway Function ◽  
Peripheral Airway
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