Intratracheal co-administration of antioxidants and ceftriaxone reduces pulmonary injury and mortality rate in an experimental model of sepsis

Respirology ◽  
2014 ◽  
Vol 19 (7) ◽  
pp. 1080-1087 ◽  
Author(s):  
Andre M. Galvão ◽  
Marcela S.O. Wanderley ◽  
Roberto A. Silva ◽  
Carlos A.M. Filho ◽  
Mário R. Melo-Junior ◽  
...  
Keyword(s):  
Mortality Rate ◽  
Experimental Model ◽  
Pulmonary Injury

Lipid peroxidation and lung ultrastructural changes in an experimental model of leukocyte-mediated pulmonary injury

Lung ◽  
1990 ◽  
Vol 168 (1) ◽  
pp. 35-42 ◽  
Author(s):  
Emma Borrelli ◽  
PierPaolo Giomarelli ◽  
Osvaldo Chiara ◽  
Alessandro Casini ◽  
Sandra Betti ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Experimental Model ◽  
Ultrastructural Changes ◽  
Pulmonary Injury

scholarly journals INFLUENCE OF MAGNETIC BLOOD TREATMENT ON THE DETOXIFICATION POTENTIAL OF HEMOPERFUSION THROUGH THE DOMESTIC HEMOSORBENT "HEMO-PROTEASOSORB" IN PATIENTS WITH SEVERE COVID-19

2021 ◽  
Vol 19 (3) ◽  
pp. 294-300
Author(s):  
R. E. Yakubtsevich ◽  
◽  
D. N. Rakashevich ◽  
I. N. Neuhen ◽  
◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Mortality Rate ◽  
Rheological Properties ◽  
Oxygen Transport ◽  
Standard Protocol ◽  
Cytokine Storm ◽  
Pulmonary Injury ◽  
Transport Function ◽  
Respiratory Index

Background: The COVID-19 infection is a disease, in severe cases of which the mortality rate in the intensive care unit is 42-62%. Its main cause is the development of a "cytokine storm" and hypoxia in pulmonary injury. It has been proven that hemoperfusion through selective hemosorbents is effective for suppressing cytokine aggression. Considering the effectiveness of hemosorption in combination with magnetic blood treatment (MBT) in patients with sepsis, which is also characterized by endotoxemia and the development of a "cytokine storm", it is important to study the effectiveness of autohemomagnetotherapy in patients with severe COVID-19. Purpose: To evaluate the effectiveness of MBT in combination with hemoperfusion through the hemosorbent "Hemo-proteazosorb" in the severe course of COVID-19 infection. Material and methods: We studied the clinical and laboratory parameters of 36 patients with a severe course of COVID-19 infection, whose treatment included extracorporeal detoxification methods. All the patients were divided into 2 groups: "Hemo-proteazosorb" (19 patients) and "Hemo-proteazosorb + MBT" (17 patients). Results: Against the background of hemoperfusion through the domestic hemosorbent "Hemo-proteazosorb" in combination with MBT, a statistically significant increase in the levels of erythrocytes, hemoglobin, lymphocytes and the respiratory index was established. In the group "Hemo-proteazosorb + MBT" there was a statistically more pronounced elimination of IL-6 in comparison with the group where only hemoperfusion was performed. Conclusion: The inclusion of MBT in the standard protocol of hemoperfusion through “Hemo-proteazosorb” sorbent increases the effectiveness of the treatment of patients with severe COVID-19 by increasing its detoxification potential, improving the oxygen transport function of the blood, stimulating lymphopoiesis and improving the rheological properties of blood.

Improvement in ARDS experimental model installation: Low mortality rate and maintenance of hemodynamic stability

2012 ◽  
Vol 65 (3) ◽  
pp. 102-106 ◽  
Author(s):  
Luciana Branco Haddad ◽  
Roberta Munhoz Manzano ◽  
Felipe de Souza Rossi ◽  
Norberto Antonio Freddi ◽  
Cristiane Prado ◽  
...  
Keyword(s):  
Mortality Rate ◽  
Experimental Model ◽  
Hemodynamic Stability

scholarly journals Cationic liposomes containing antioxidants reduces pulmonary injury in experimental model of sepsis

2016 ◽  
Vol 231 ◽  
pp. 55-62 ◽  
Author(s):  
Andre Martins Galvão ◽  
Júlia Siqueira Galvão ◽  
Marcela Araújo Pereira ◽  
Pabyton Gonçalves Cadena ◽  
Nereide Stella Santos Magalhães ◽  
...  
Keyword(s):  
Experimental Model ◽  
Cationic Liposomes ◽  
Pulmonary Injury

scholarly journals Effect of DDAVP on Endotoxin-Induced Intravascular Coagulation in Rabbits

1992 ◽  
Vol 68 (03) ◽  
pp. 306-309 ◽  
Author(s):  
M J Paloma ◽  
J A Páramo ◽  
E Rocha
Keyword(s):  
Mortality Rate ◽  
Experimental Model ◽  
Arginine Vasopressin ◽  
Mortality Rates ◽  
Control Group ◽  
Factor Xii ◽  
Fibrin Deposition ◽  
E Coli ◽  
Intravascular Coagulation ◽  
Pai 1

SummaryWe have evaluated the effect of l-Deamino-8D-arginine vasopressin (DDAVP) on an experimental model of intravascular coagulation (DIC) induced in rabbits by injection of 20 µg kg–1 h–1 during 6 h of E. coli lipopolysaccharide. DDAVP significantly ameliorated the platelet drop and fibrinogen decrease (p <0.01) induced by endotoxin in control animals. A significant reduction in factor XII consumption (p <0.01) and a decrease in the generation of endotoxin induced PAI-1 activity in rabbits circulation was also observed (p <0.005). Moreover, fibrin deposition in kidneys of rabbits receiving DDAVP was significantly reduced as compared to control animals. Finally, the mortality rate in the control group was significantly higher than in DDAVP-treated rabbits (p <0.01). The hemostatic changes induced by DDAVP correlated with lower fibrin deposition and reduction in mortality rates.

Ultrastructural Alterations in Sinusoidal Endothelial Fenestrae as a Result of Hypoxia

1976 ◽  
Vol 34 ◽  
pp. 168-169
Author(s):  
Waykin Nopanitaya ◽  
Raeford E. Brown ◽  
Joe W. Grisham ◽  
Johnny L. Carson
Keyword(s):  
Endothelial Cells ◽  
Experimental Model ◽  
Hepatic Lobule ◽  
Ultrastructural Alterations ◽  
Large Type ◽  
Sinusoidal Endothelial Fenestrae ◽  
General Size ◽  
Sem Studies

Mammalian endothelial cells lining hepatic sinusoids have been found to be widely fenestrated. Previous SEM studies (1,2) have noted two general size catagories of fenestrations; large fenestrae were distributed randomly while the small type occurred in groups. These investigations also reported that large fenestrae were more numerous and larger in the endothelial cells at the afferent ends of sinusoids or around the portal areas, whereas small fenestrae were more numerous around the centrilobular portion of the hepatic lobule. It has been further suggested that under some physiologic conditions small fenestrae could fuse and subsequently become the large type, but this is, as yet, unproven.We have used a reproducible experimental model of hypoxia to study the ultrastructural alterations in sinusoidal endothelial fenestrations in order to investigate the origin of occurrence of large fenestrae.

174 Early beneficial effects of vasopeptidase inhibtion n an experimental model of heart failure

2003 ◽  
Vol 2 (1) ◽  
pp. 33-34
Author(s):  
B SHIVALKAR ◽  
B MEURIS ◽  
R VANBENEDEN ◽  
J KETESLEGERS ◽  
F BECKERS ◽  
...  
Keyword(s):  
Heart Failure ◽  
Experimental Model ◽  
Beneficial Effects

Surgical and endovascular hybrid approach in peripheral arterial disease of the lower limbs

VASA ◽  
2016 ◽  
Vol 45 (5) ◽  
pp. 417-422 ◽  
Author(s):  
Anouk Grandjean ◽  
Katia Iglesias ◽  
Céline Dubuis ◽  
Sébastien Déglise ◽  
Jean-Marc Corpataux ◽  
...  
Keyword(s):  
Mortality Rate ◽  
Peripheral Arterial Disease ◽  
Limb Salvage ◽  
Hybrid Approach ◽  
Arterial Disease ◽  
Early Mortality ◽  
Secondary Patency ◽  
Limb Salvage Rate ◽  
Peripheral Arterial ◽  
Salvage Rate

Abstract. Background: Multilevel peripheral arterial disease is frequently observed in patients with intermittent claudication or critical limb ischemia. This report evaluates the efficacy of one-stage hybrid revascularization in patients with multilevel arterial peripheral disease. Patients and methods: A retrospective analysis of a prospective database included all consecutive patients treated by a hybrid approach for a multilevel arterial peripheral disease. The primary outcome was the patency rate at 6 months and 1 year. Secondary outcomes were early and midterm complication rate, limb salvage and mortality rate. Statistical analysis, including a Kaplan-Meier estimate and univariate and multivariate Cox regression analyses were carried out with the primary, primary assisted and secondary patency, comparing the impact of various risk factors in pre- and post-operative treatments. Results: 64 patients were included in the study, with a mean follow-up time of 428 days (range: 4 − 1140). The technical success rate was 100 %. The primary, primary assisted and secondary patency rates at 1 year were 39 %, 66 % and 81 %, respectively. The limb-salvage rate was 94 %. The early mortality rate was 3.1 %. Early and midterm complication rates were 15.4 % and 6.4 %, respectively. The early mortality rate was 3.1 %. Conclusions: The hybrid approach is a major alternative in the treatment of peripheral arterial disease in multilevel disease and comorbid patients, with low complication and mortality rates and a high limb-salvage rate.

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