Monitoring mRNA transcription of genes involved in early pregnancy from endometrium and peripheral blood mononuclear cells of pregnant pigs with different parity

2018 ◽  
Vol 53 (6) ◽  
pp. 1594-1599
Author(s):  
Sang‐Pil Choi ◽  
Yong‐Chan Choi ◽  
Jun Yang ◽  
Chang‐Yong Choi ◽  
Chang‐Hee Lee ◽  
...  
Keyword(s):  
Peripheral Blood Mononuclear Cells ◽  
Early Pregnancy ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Mrna Transcription ◽  
Peripheral Blood Mononuclear ◽  
Blood Mononuclear Cells

Changes in expression of Th1 and Th2 cytokines in bovine peripheral blood mononuclear cells during early pregnancy

2015 ◽  
Author(s):  
Ling YANG ◽  
Yongxiang WANG ◽  
Xingshu MA ◽  
Songping WANG ◽  
Leying ZHANG
Keyword(s):  
Peripheral Blood Mononuclear Cells ◽  
Early Pregnancy ◽  
Peripheral Blood ◽  
Blood Circulation ◽  
Mononuclear Cells ◽  
Th2 Cytokines ◽  
Peripheral Blood Mononuclear ◽  
Blood Mononuclear Cells ◽  
Th1 And Th2 Cytokines ◽  
Th1 And Th2

Conceptus-derived signals are involved in the maternal systemic immune regulation through blood circulation and lymph circulation by peripheral blood mononuclear cells (PBMC) in cattle. There exists a Th2-biased response in maternal uterus during early pregnancy in cattle. However, it is unclear that the changes in expression of Th1 and Th2 cytokines in PBMC during early pregnancy in cows. At present study, the expression of Th1 and Th2 cytokines in PBMC were explored at day 18 non-pregnant cows, day 18 and day 30 pregnant cows. Our results showed that IFN-?, was attenuated in PBMC, but TNF-a and IL-4 in PBMC were up-regulated during early pregnancy in cows. However, the member of the Th2 cytokines, including IL-4, IL-5, IL-6, IL-10 and IL-13, was augmented in day 30 pregnant PBMC. In conclusion, there existed a Th2-biased response in PBMC during early pregnancy, which was essential for successful pregnancy in cattle.

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