Inhibition of FGF Signalling Pathway Augments the Expression of Pluripotency and Trophoblast Lineage Marker Genes in Porcine Parthenogenetic Blastocyst

2016 ◽  
Vol 51 (5) ◽  
pp. 649-656 ◽  
Author(s):  
LY Li ◽  
MM Li ◽  
SF Yang ◽  
J Zhang ◽  
Z Li ◽  
...  
Keyword(s):  
Signalling Pathway ◽  
Marker Genes ◽  
Fgf Signalling ◽  
Lineage Marker

scholarly journals Sprouty genes function as negative regulators of the FGF signalling pathway during cerebellar development

2010 ◽  
Vol 344 (1) ◽  
pp. 443
Author(s):  
Tian Yu ◽  
Yuichiro Yaguchi ◽  
Diego Echevarria ◽  
Salvador Martinez ◽  
Robert Wechsler-Reya ◽  
...  
Keyword(s):  
Signalling Pathway ◽  
Cerebellar Development ◽  
Negative Regulators ◽  
Fgf Signalling

scholarly journals Candidate lineage marker genes in human preimplantation embryos

2004 ◽  
Vol 8 (5) ◽  
pp. 577-583 ◽  
Author(s):  
Christoph Hansis ◽  
James A Grifo ◽  
Lewis C Krey
Keyword(s):  
Preimplantation Embryos ◽  
Marker Genes ◽  
Lineage Marker ◽  
Human Preimplantation Embryos

Expression of Fgf signalling pathway related genes during palatal rugae development in the mouse

2010 ◽  
Vol 10 (4-5) ◽  
pp. 193-198 ◽  
Author(s):  
Thantrira Porntaveetus ◽  
Shelly Oommen ◽  
Paul T. Sharpe ◽  
Atsushi Ohazama
Keyword(s):  
Signalling Pathway ◽  
Palatal Rugae ◽  
Fgf Signalling

scholarly journals FGF signalling plays similar roles in development and regeneration of the skeleton in the brittle star Amphiura filiformis

2019 ◽  
Author(s):  
Anna Czarkwiani ◽  
David V. Dylus ◽  
Luisana Carballo ◽  
Paola Oliveri
Keyword(s):  
Large Scale ◽  
Developmental Process ◽  
Skeletal Development ◽  
Signalling Pathway ◽  
Brittle Star ◽  
Differential Analysis ◽  
Regulatory Module ◽  
Amphiura Filiformis ◽  
Fgf Signalling ◽  
First Time

AbstractRegeneration is an adult developmental process considered to be an epiphenomenon of embryonic development. Although several studies have shown that various embryonic genes are expressed during regeneration, there have been no large-scale, direct and functional comparative studies between the development and regeneration of a specific structure in one animal. Here, we use the brittle star Amphiura filiformis to characterise the role of the FGF signalling pathway during skeletal development and regeneration. In both processes, we find the ligands expressed in ectodermal cells flanking underlying mesodermal cells, and the receptors expressed specifically by these skeletogenic cells. Perturbation of FGF but not VEGF signalling during skeletogenesis completely inhibited skeleton formation in both embryogenesis and regeneration, without affecting other key developmental processes like cell migration or proliferation. Transcriptome-wide differential analysis identified a highly similar cohort of skeletogenic differentiation genes downstream of the FGF signalling pathway, whereas upstream transcription factors involved in the initial specification of the skeletogenic lineage where unaffected. Comparison to the sea urchin indicated that many of the affected genes are associated with differentiation. Moreover, several genes showed no homology to a cohort from other species, leading to the discovery of brittle star specific, downstream skeletogenic genes. In conclusion, our results show that the FGF pathway is crucial for skeletogenesis in the brittle star, as it is in other deuterostomes, and for the first time provide evidence for the re-deployment of a gene regulatory module during both regeneration and development.

[P1.41]: Sprouty genes function as negative regulators of the FGF signalling pathway during cerebellar development

2010 ◽  
Vol 28 (8) ◽  
pp. 669-669
Author(s):  
T. Yu ◽  
Y. Yaguchi ◽  
D. Echevarria ◽  
S. Martinez ◽  
R. Wechsler‐Reya ◽  
...  
Keyword(s):  
Signalling Pathway ◽  
Cerebellar Development ◽  
Negative Regulators ◽  
Fgf Signalling

scholarly journals FGFRL1 is a neglected putative actor of the FGF signalling pathway present in all major metazoan phyla

2009 ◽  
Vol 9 (1) ◽  
pp. 226 ◽  
Author(s):  
Stephanie Bertrand ◽  
Ildiko Somorjai ◽  
Jordi Garcia-Fernandez ◽  
Thomas Lamonerie ◽  
Hector Escriva
Keyword(s):  
Signalling Pathway ◽  
Fgf Signalling

scholarly journals 13-P144 Sprouty genes function as negative regulators of the FGF signalling pathway during cerebellar development

2009 ◽  
Vol 126 ◽  
pp. S237-S238
Author(s):  
Tian Yu ◽  
Yuichiro Yaguchi ◽  
Diego Echevarria ◽  
Salvador Martinez ◽  
Albert Basson
Keyword(s):  
Signalling Pathway ◽  
Cerebellar Development ◽  
Negative Regulators ◽  
Fgf Signalling

Knockdown of CTRP6 inhibits adipogenesis via lipogenic marker genes and Erk1/2 signalling pathway

2015 ◽  
Vol 39 (5) ◽  
pp. 554-562 ◽  
Author(s):  
Wen-jing Wu ◽  
De-lin Mo ◽  
Cun-zhen Zhao ◽  
Chen Zhao ◽  
Yao-sheng Chen ◽  
...  
Keyword(s):  
Signalling Pathway ◽  
Marker Genes
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