A Non-Reciprocal Autosomal Translocation 64,XX, t(4;10)(q21;p15) in an Arabian Mare with Repeated Early Embryonic Loss

2015 ◽  
Vol 51 (1) ◽  
pp. 171-174 ◽  
Author(s):  
S Ghosh ◽  
PJ Das ◽  
F Avila ◽  
BK Thwaits ◽  
BP Chowdhary ◽  
...  
Keyword(s):  
Embryonic Loss ◽  
Autosomal Translocation

Aspermia, associated with a presumably balanced X/autosomal translocation

1976 ◽  
Vol 31 (1) ◽  
pp. 97-106 ◽  
Author(s):  
S. Stengel-Rutkowski ◽  
H. Zankl ◽  
A. Rodewald ◽  
S. Scharrer ◽  
J. P. Chaudhuri ◽  
...  
Keyword(s):  
Autosomal Translocation

The A6936G polymorphism of the endothelial protein C receptor gene is associated with the risk of unexplained foetal loss in Mediterranean European couples

2009 ◽  
Vol 102 (10) ◽  
pp. 656-667 ◽  
Author(s):  
Pascale Fabbro-Peray ◽  
Pierre Marès ◽  
Patrick Mismetti ◽  
Géraldine Lissalde-Lavigne ◽  
Éva Cochery-Nouvellon ◽  
...  
Keyword(s):  
Protein C ◽  
Pregnancy Loss ◽  
Receptor Gene ◽  
Coagulation Factor ◽  
Factor V ◽  
Endothelial Protein C Receptor ◽  
Foetal Loss ◽  
Factor Ii ◽  
Embryonic Loss ◽  
Factor V Gene

SummaryThe endothelial protein C receptor (EPCR) is expressed by trophoblast cells. Mid-gestation pregnancy loss is described in animals with a haemochorial placenta lacking EPCR. The A6936G allele of the EPCR gene (PROCR) may be associated with lower EPCR densities on trophoblasts, but data are lacking for its effect on the risk of pregnancy loss in humans. A 1:2 case-control study on unexplained pregnancy loss was nested in the NOHA First cohort: 3,218 case couples and 6,436 control couples were studied for PROCR A6936G, coagulation factor V gene (F5) G1691A and coagulation factor II gene (F2) G20210A polymorphisms. Ethnicity and time of pregnancy loss defined through biometry-based gestational ages (embryonic loss < 10th week ≥ foetal loss) were analysed. The PROCR A6936G allele, in mothers and fathers, was associated only with foetal loss in both Europeans and non-Europeans. Increasing probability levels of carrying a homozygous child were increasingly associated with the risk of foetal demise. The F5 G1691A and F2 G20210A alleles, only in mothers, were only and independently associated with foetal loss in Europeans. In our population, the PROCR A6936G allele describes women, but also men and thus couples, at risk for first unexplained foetal loss. This risk is independent of the foetal loss risk conferred to our local Mediterranean European women by the F5 G1691A and F2 G20210A alleles. Data confirm that the relationship between thrombophilias and pregnancy loss varies according to ethnicity and loss type.

scholarly journals Neonatally Induced Mild Diabetes in Rats and Its Effect on Maternal, Placental, and Fetal Parameters

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Yuri Karen Sinzato ◽  
Gustavo Tadeu Volpato ◽  
Isabela Lovizutto Iessi ◽  
Aline Bueno ◽  
Iracema de Mattos Paranhos Calderon ◽  
...  
Keyword(s):  
Fetal Development ◽  
Diabetic Rats ◽  
Female Rats ◽  
Corpora Lutea ◽  
Reproductive Outcomes ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Insulin Tolerance ◽  
Mild Diabetes ◽  
Embryonic Loss

The aim of this study was to assess placental changes and reproductive outcomes in neonatally induced mild diabetic dams and fetal development in their offspring. At birth, female rats were assigned either to control or diabetic group (100 mg of streptozotocin/Kg, subcutaneously). At adulthood, the female rats were mated. During pregnancy, the blood glucose levels and glucose and insulin tolerance tests were performed. At term, maternal reproductive outcomes, fetal and placental weight, and placental morphology were analyzed. Diabetic rats had smaller number of living fetuses, implantations and corpora lutea, and increased rate of embryonic loss. Placenta showed morphometric alterations in decidua area. Our results showed that mild diabetes was sufficient to trigger alterations in maternal organism leading to impaired decidua development contributing to failure in embryonic implantation and early embryonic losses. Regardless placental decidua alteration, the labyrinth, which is responsible for the maternal-fetal exchanges, showed no morphometric changes contributing to an appropriate fetal development, which was able to maintain normal fetal weight at term in mild diabetic rats. Thus, this experimental model of diabetes induction at the day of birth was more effective to reproduce the reproductive alterations of diabetic women.

Quinacrine mustard fluorescence of a second Y chromosome in a Y-autosomal translocation

1972 ◽  
Vol 14 (2) ◽  
pp. 133-136 ◽  
Author(s):  
Sabine Fr�nd ◽  
Thea Koske-Westphal ◽  
Sigrun Fuchs-Mecke ◽  
Eberhard Passarge
Keyword(s):  
Y Chromosome ◽  
Autosomal Translocation

scholarly journals Identification of novel candidate factor SNX5 specific for pregnancy failure in Holstein heifers

2021 ◽  
Author(s):  
Kazuya Kusama ◽  
Rulan Bai ◽  
Yuta Matsuno ◽  
Atsushi Ideta ◽  
Toshihiro Sakurai ◽  
...  
Keyword(s):  
Early Pregnancy ◽  
Pregnancy Loss ◽  
Molecular Mechanisms ◽  
Characteristic Curve ◽  
Area Under The Curve ◽  
Metabolome Analysis ◽  
Itraq Analysis ◽  
Embryonic Loss ◽  
Extraembryonic Membranes ◽  
Serum Components

Abstract Pregnancy loss predominantly occurs during periods between blastocyst hatching and conceptus (embryo plus extraembryonic membranes) implantation to the endometrium in cattle. Insufficient biochemical communication between conceptus and endometrium has been suspected as the primary cause for early embryonic losses. If molecules regulating this communication were identified, molecular mechanisms associated with early pregnancy success or loss could be better understood. To identify novel factors as detection markers of non-pregnant or females undergoing embryonic loss, blood sera from embryo-transferred heifers on day 7 (day 0 = day of estrus) were collected on day 17, 20, or 22, which were subjected to metabolome and global proteome iTRAQ analyses. On each sample, the metabolome analysis partly divided serum components into pregnant or not. In the iTRAQ analysis, heatmap analysis with 25 unique proteins separated into pregnant or not on day 20 or 22. Furthermore, receiver operating characteristic curve (ROC) analysis identified five candidate proteins detecting non-pregnant heifers, of which SNX5 in day 22 sera had the highest area under the curve (AUC), 0.983. We also detected SNX5 in day 22 sera from non-pregnant heifers using western blotting. These results suggest that high SNX5 in day 22 sera could predict early pregnancy loss in heifers.

scholarly journals Lower embryonic loss rates among twin gestations following assisted reproduction

2005 ◽  
Vol 22 (5) ◽  
pp. 181-184 ◽  
Author(s):  
G. B. La Sala ◽  
G. Nucera ◽  
A. Gallinelli ◽  
A. Nicoli ◽  
M. T. Villani ◽  
...  
Keyword(s):  
Assisted Reproduction ◽  
Embryonic Loss ◽  
Loss Rates
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