Leptin and Leptin Receptor Gene Expression in the Canine Corpus Luteum During Diestrus, Pregnancy and after Aglepristone-Induced Luteolysis

2012 ◽  
Vol 47 ◽  
pp. 40-42 ◽  
Author(s):  
O Balogh ◽  
MP Kowalewski ◽  
IM Reichler
Keyword(s):  
Gene Expression ◽  
Corpus Luteum ◽  
Leptin Receptor ◽  
Receptor Gene ◽  
Receptor Gene Expression

Hormonal regulation of prostaglandin F2 alpha receptor gene expression in mouse ovary

1996 ◽  
Vol 271 (4) ◽  
pp. E686-E693
Author(s):  
J. Sugatani ◽  
Y. Masu ◽  
M. Nishizawa ◽  
K. Sakamoto ◽  
T. Houtani ◽  
...  
Keyword(s):  
Gene Expression ◽  
Corpus Luteum ◽  
Hormonal Regulation ◽  
Receptor Gene ◽  
Mrna Level ◽  
Dependent Manner ◽  
Mouse Ovary ◽  
Receptor Mrna ◽  
Prostaglandin F2 Alpha ◽  
Receptor Gene Expression

In this study we examined regulation by pituitary gonadotropins of the prostaglandin F2 alpha (PGF2 alpha) receptor gene expression in the mouse ovary. Administration of pregnant mare serum gonadotropin (PMSG) to 35-day-old mice in the diestrus phase stimulated the ovary and enhanced the production of progesterone at 1 h PMSG also increased the ovarian PGF2 alpha receptor mRNA level in a time-dependent manner, reaching a sixfold maximum at 1 h. These actions of PMSG were mimicked by human chorionic gonadotropin (hCG), follicle-stimulating hormone (FSH), and cholera toxin, all of which elevate intracellular adenosine 3',5'-cyclic monophosphate (cAMP). In situ hybridization revealed that PGF2 alpha receptor mRNA was localized to the corpus luteum, but the intensity of staining varied among corpora lutea in the same ovary. Exogenous PGF2 alpha inhibited the PMSG-stimulated progesterone production. These results demonstrate that gonadotropins may induce the expression of the PGF2 alpha receptor gene in luteal cells of the corpus luteum, probably by acting through a cAMP-mediated pathway, and that expression of the PGF2 alpha receptor may be functionally associated with the decrease in serum progesterone level.

LEPTIN RECEPTOR GENE EXPRESSION IN THE CHOROID PLEXUS IS INFLUENCED BY STAGE OF DEVELOPMENT AND MATERNAL STRESS IN THE GILT

2007 ◽  
Vol 77 (Suppl_1) ◽  
pp. 171-171
Author(s):  
Chad O'Gorman ◽  
Elizabeth Gonzales ◽  
Matthew Eaton ◽  
Paige Williams ◽  
Maribel Reyna ◽  
...  
Keyword(s):  
Gene Expression ◽  
Choroid Plexus ◽  
Leptin Receptor ◽  
Maternal Stress ◽  
Receptor Gene ◽  
Stage Of Development ◽  
Receptor Gene Expression

scholarly journals Circulating leptin during ovine pregnancy in relation to maternal nutrition, body composition and pregnancy outcome

2001 ◽  
Vol 169 (3) ◽  
pp. 465-476 ◽  
Author(s):  
L Thomas ◽  
JM Wallace ◽  
RP Aitken ◽  
JG Mercer ◽  
P Trayhurn ◽  
...  
Keyword(s):  
Gene Expression ◽  
Body Composition ◽  
Adipose Tissue ◽  
Dietary Intake ◽  
Leptin Receptor ◽  
Maternal Nutrition ◽  
Receptor Gene ◽  
Mrna Levels ◽  
Tissue Samples ◽  
Receptor Gene Expression

This study examined the pattern of circulating leptin in age-matched sheep during adolescent pregnancy, and its relationship with maternal dietary intake, body composition and tissue expression of the leptin gene. Overfeeding the adolescent pregnant ewe results in rapid maternal growth at the expense of the placenta, leading to growth restriction in the fetus, compared with normal fed controls. Our results demonstrate that, in the adolescent ewe, overfeeding throughout pregnancy was associated with higher maternal leptin concentrations, when compared with moderately fed controls (P<0.05), with no peak in circulating leptin towards the end of pregnancy. There was a close correlation between indices of body composition and circulating leptin levels at day 104 of gestation and at term (P<0.03). Further, when the dietary intake was switched from moderate to high, or high to moderate, at day 50 of gestation, circulating leptin levels changed rapidly, in parallel with the changes in dietary intake. Leptin mRNA levels and leptin protein in perirenal adipose tissue samples, taken at day 128 of gestation, were higher in overfed dams (P<0.04), suggesting that adipose tissue was the source of the increase in circulating leptin in the overnourished ewes. Leptin protein was also detected in placenta but leptin gene expression was negligible. However, leptin receptor gene expression was detected in the ovine placenta, suggesting that the placenta is a target organ for leptin. A negative association existed between maternal circulating leptin and fetal birth weight, placental/cotyledon weight and cotyledon number. In conclusion, in this particular ovine model, hyperleptinaemia was not observed during late pregnancy. Instead, circulating leptin concentrations reflected increased levels of leptin secretion by adipose tissue primarily as a result of the increase in body fat deposition, due to overfeeding. However, there appears to be a direct effect of overfeeding, particularly in the short term. In the nutritional switch-over study, circulating leptin concentrations changed within 48 h of the change in dietary intake. The presence of leptin protein and leptin receptor gene expression in the placenta suggests that leptin could be involved in nutrient partitioning during placental and/or fetal development.

OMEGA-3 POLYUNSATURATED FATTY ACIDS AFFECT LEPTIN RECEPTOR GENE EXPRESSION IN PITUITARY GH4C1 CELL LINE

2009 ◽  
Vol 16 (3) ◽  
pp. 382-393 ◽  
Author(s):  
RITA DI BENEDETTO ◽  
SERAFINA SALVATI ◽  
LUCILLA ATTORRI ◽  
ANTONELLA DI BIASE
Keyword(s):  
Gene Expression ◽  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Cell Line ◽  
Leptin Receptor ◽  
Receptor Gene ◽  
Omega 3 ◽  
Receptor Gene Expression

scholarly journals Leptin and insulin downregulate leptin receptor gene expression in chicken-derived leghorn male hepatoma cells

2003 ◽  
Vol 82 (10) ◽  
pp. 1573-1579 ◽  
Author(s):  
S Cassy ◽  
M Derouet ◽  
S Crochet ◽  
S Dridi ◽  
M Taouis
Keyword(s):  
Gene Expression ◽  
Leptin Receptor ◽  
Receptor Gene ◽  
Hepatoma Cells ◽  
Receptor Gene Expression

scholarly journals Inhibition of Leptin and Leptin Receptor Gene Expression by Silibinin-Curcumin Combination

2013 ◽  
Vol 14 (11) ◽  
pp. 6595-6599 ◽  
Author(s):  
Kazem Nejati-Koshki ◽  
Abolfazl Akbarzadeh ◽  
Mohammad Pourhasan-Moghaddam ◽  
Alireza Abhari ◽  
Hassan Dariushnejad
Keyword(s):  
Gene Expression ◽  
Leptin Receptor ◽  
Receptor Gene ◽  
Receptor Gene Expression

Eicosapentaenoic acid stimulates leptin receptor gene expression in the hypothalamus of newborn rats

2007 ◽  
Vol 27 (6) ◽  
pp. 367-371 ◽  
Author(s):  
Rita Di Benedetto ◽  
Lucilla Attorri ◽  
Serafina Salvati ◽  
Fabiana Leonardi ◽  
Antonella Di Biase
Keyword(s):  
Gene Expression ◽  
Eicosapentaenoic Acid ◽  
Leptin Receptor ◽  
Receptor Gene ◽  
Newborn Rats ◽  
Receptor Gene Expression

scholarly journals Leptin receptor gene expression and number in the brain are regulated by leptin level and nutritional status

2009 ◽  
Vol 587 (14) ◽  
pp. 3573-3585 ◽  
Author(s):  
Sharon E. Mitchell ◽  
Ruben Nogueiras ◽  
Amanda Morris ◽  
Sulay Tovar ◽  
Christine Grant ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nutritional Status ◽  
Leptin Receptor ◽  
Receptor Gene ◽  
The Brain ◽  
Receptor Gene Expression
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