Intestinal alkaline phosphatase in the gastrointestinal tract of fish: biology, ontogeny, and environmental and nutritional modulation

2019 ◽  
Vol 12 (2) ◽  
pp. 555-581 ◽  
Author(s):  
Jean‐Paul Lallès
Keyword(s):  
Alkaline Phosphatase ◽  
Gastrointestinal Tract ◽  
Intestinal Alkaline Phosphatase ◽  
Fish Biology ◽  
Nutritional Modulation

scholarly journals The Role of Intestinal Alkaline Phosphatase in Inflammatory Disorders of Gastrointestinal Tract

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Jan Bilski ◽  
Agnieszka Mazur-Bialy ◽  
Dagmara Wojcik ◽  
Janina Zahradnik-Bilska ◽  
Bartosz Brzozowski ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Gastrointestinal Tract ◽  
Intestinal Inflammation ◽  
Stressful Events ◽  
Intestinal Lumen ◽  
Barrier Dysfunction ◽  
Intestinal Alkaline Phosphatase ◽  
Protective Mechanisms ◽  
Brush Border Enzyme

Over the past few years, the role of intestinal alkaline phosphatase (IAP) as a crucial mucosal defence factor essential for maintaining gut homeostasis has been established. IAP is an important apical brush border enzyme expressed throughout the gastrointestinal tract and secreted both into the intestinal lumen and into the bloodstream. IAP exerts its effects through dephosphorylation of proinflammatory molecules including lipopolysaccharide (LPS), flagellin, and adenosine triphosphate (ATP) released from cells during stressful events. Diminished activity of IAP could increase the risk of disease through changes in the microbiome, intestinal inflammation, and intestinal permeability. Exogenous IAP exerts a protective effect against intestinal and systemic inflammation in a variety of diseases and represents a potential therapeutic agent in diseases driven by gut barrier dysfunction such as IBD. The intestinal protective mechanisms are impaired in IBD patients due to lower synthesis and activity of endogenous IAP, but the pathomechanism of this enzyme deficiency remains unclear. IAP has been safely administered to humans and the human recombinant form of IAP has been developed. This review was designed to provide an update in recent research on the involvement of IAP in intestinal inflammatory processes with focus on IBD in experimental animal models and human patients.

scholarly journals Influence of Secretin and Cholecystokinin on Intestinal Alkaline Phosphatase Secretion

1973 ◽  
Vol 64 (4) ◽  
pp. 599-602 ◽  
Author(s):  
Walter P. Dyck ◽  
George A. Martin ◽  
Charles R. Ratliff
Keyword(s):  
Alkaline Phosphatase ◽  
Intestinal Alkaline Phosphatase

scholarly journals Characterization and comparison of soluble and membranous forms of intestinal alkaline phosphatase from the suckling rat.

1981 ◽  
Vol 256 (11) ◽  
pp. 5620-5626
Author(s):  
S.T. Yedlin ◽  
G.P. Young ◽  
B. Seetharam ◽  
S. Seetharam ◽  
D.H. Alpers
Keyword(s):  
Alkaline Phosphatase ◽  
Intestinal Alkaline Phosphatase

scholarly journals Sequence and characterization of the human intestinal alkaline phosphatase gene.

1988 ◽  
Vol 263 (24) ◽  
pp. 12011-12019 ◽  
Author(s):  
P S Henthorn ◽  
M Raducha ◽  
T Kadesch ◽  
M J Weiss ◽  
H Harris
Keyword(s):  
Alkaline Phosphatase ◽  
Intestinal Alkaline Phosphatase

scholarly journals A summary of feed additives, intestinal health and intestinal alkaline phosphatase in piglet nutrition

2020 ◽  
Vol 65 (No. 8) ◽  
pp. 281-294
Author(s):  
Jansller Genova ◽  
Antonio Melo ◽  
Paulo Rupolo ◽  
Silvana Carvalho ◽  
Leandro Costa ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Structural Changes ◽  
Stress Factors ◽  
Intestinal Microbiome ◽  
Resistant Bacteria ◽  
Feeding Strategies ◽  
High Morbidity ◽  
Intestinal Health ◽  
Growth Promoters ◽  
Intestinal Alkaline Phosphatase

Weaning is considered the “critical window” in the piglet’s life because it is associated with several stress factors, such as loss of contact with the mother and original litter, solid diet, environmental and structural changes, and the establishment of a new hierarchy. During this abrupt period, several events such as reduced feed intake, high morbidity, susceptibility to enteric infections and post-weaning diarrhoea are observed. The nutritional landscape of the piglet gut is modified, which can compromise the maturity of the gastrointestinal system, the stable intestinal microbiome and the active immunity developed as an indicator of intestinal health. However, with increased awareness of feed safety issues and the development of drug-resistant bacteria, the interest in producing pigs without the use of antimicrobial growth promoters (AGP) is increasing, since long-term use and therapeutic doses of AGP can contribute to the reduction of bacterial diversity and increase of inflammatory bowel disease (IBD). Thus, the most widely researched alternatives include the use of feed additives, feeding strategies, nutraceuticals/functional foods and available handling that can reduce the risk of IBD beyond basic nutritional functions. Studies have reported intestinal alkaline phosphatase as a new nutritional therapy associated with intestinal health which may be a “key additive” in the AGP replacement. In this review article, the purpose is to show some current aspects of feed additive research, addressing a concept of the “intestinal health” from different points of view and properties of alkaline phosphatase.

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