scholarly journals Neural signature of delayed fear generalization under stress

2021 ◽  
Author(s):  
Franziska Magdalena Kausche ◽  
Gundula Zerbes ◽  
Lea Kampermann ◽  
Christian Büchel ◽  
Lars Schwabe
Keyword(s):  
Neural Signature ◽  
Fear Generalization

Effects of an Anxiety-Specific Psychometric Factor on Fear Conditioning and Fear Generalization

2017 ◽  
Vol 225 (3) ◽  
pp. 200-213 ◽  
Author(s):  
Christian Baumann ◽  
Miriam A. Schiele ◽  
Martin J. Herrmann ◽  
Tina B. Lonsdorf ◽  
Peter Zwanzger ◽  
...  
Keyword(s):  
Risk Factor ◽  
Anxiety Disorders ◽  
Fear Conditioning ◽  
Longitudinal Design ◽  
Principal Component ◽  
Anxiety And Depression ◽  
Specific Factor ◽  
High Anxious ◽  
Two Factors ◽  
Fear Generalization

Abstract. Conditioning and generalization of fear are assumed to play central roles in the pathogenesis of anxiety disorders. Here we investigate the influence of a psychometric anxiety-specific factor on these two processes, thus try to identify a potential risk factor for the development of anxiety disorders. To this end, 126 healthy participants were examined with questionnaires assessing symptoms of anxiety and depression and with a fear conditioning and generalization paradigm. A principal component analysis of the questionnaire data identified two factors representing the constructs anxiety and depression. Variations in fear conditioning and fear generalization were solely associated with the anxiety factor characterized by anxiety sensitivity and agoraphobic cognitions; high-anxious individuals exhibited stronger fear responses (arousal) during conditioning and stronger generalization effects for valence and UCS-expectancy ratings. Thus, the revealed psychometric factor “anxiety” was associated with enhanced fear generalization, an assumed risk factor for anxiety disorders. These results ask for replication with a longitudinal design allowing to examine their predictive validity.

The effects of early life stress on context fear generalization in adult rats.

2019 ◽  
Vol 133 (1) ◽  
pp. 50-58 ◽  
Author(s):  
Nathalie D. Elliott ◽  
Rick Richardson
Keyword(s):  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Adult Rats ◽  
Fear Generalization

The inhibitive effect of positive emotions on fear generalization

2017 ◽  
Vol 49 (3) ◽  
pp. 317 ◽  
Author(s):  
Biao FENG ◽  
Liang XU ◽  
Weixing ZHANG ◽  
Ting CHEN ◽  
Wenqing WANG ◽  
...  
Keyword(s):  
Positive Emotions ◽  
Fear Generalization

The neural mechanism of fear generalization based on perception

2018 ◽  
Vol 26 (8) ◽  
pp. 1391
Author(s):  
Yi LEI ◽  
Ying MEI ◽  
Wenhai ZHANG ◽  
Hong LI
Keyword(s):  
Neural Mechanism ◽  
Fear Generalization

scholarly journals A cross-species neural integration of gravity for motor optimization

2021 ◽  
Vol 7 (15) ◽  
pp. eabf7800
Author(s):  
Jeremie Gaveau ◽  
Sidney Grospretre ◽  
Bastien Berret ◽  
Dora E. Angelaki ◽  
Charalambos Papaxanthis
Keyword(s):  
Optimization Strategy ◽  
Motor Patterns ◽  
Activation Patterns ◽  
Single Degree Of Freedom ◽  
Single Degree ◽  
Neural Integration ◽  
Gravity Effects ◽  
Neural Signature ◽  
Experimental Findings ◽  
Muscular Activation

Recent kinematic results, combined with model simulations, have provided support for the hypothesis that the human brain shapes motor patterns that use gravity effects to minimize muscle effort. Because many different muscular activation patterns can give rise to the same trajectory, here, we specifically investigate gravity-related movement properties by analyzing muscular activation patterns during single-degree-of-freedom arm movements in various directions. Using a well-known decomposition method of tonic and phasic electromyographic activities, we demonstrate that phasic electromyograms (EMGs) present systematic negative phases. This negativity reveals the optimal motor plan’s neural signature, where the motor system harvests the mechanical effects of gravity to accelerate downward and decelerate upward movements, thereby saving muscle effort. We compare experimental findings in humans to monkeys, generalizing the Effort-optimization strategy across species.

scholarly journals Incerto-thalamic modulation of fear via GABA and dopamine

2021 ◽  
Author(s):  
Archana Venkataraman ◽  
Sarah C. Hunter ◽  
Maria Dhinojwala ◽  
Diana Ghebrezadik ◽  
JiDong Guo ◽  
...  
Keyword(s):  
Brain Regions ◽  
Zona Incerta ◽  
Dependent Manner ◽  
Post Traumatic Stress ◽  
Functional Roles ◽  
Functional Connections ◽  
Optogenetic Stimulation ◽  
Fear Generalization ◽  
Stimulation Of

AbstractFear generalization and deficits in extinction learning are debilitating dimensions of Post-Traumatic Stress Disorder (PTSD). Most understanding of the neurobiology underlying these dimensions comes from studies of cortical and limbic brain regions. While thalamic and subthalamic regions have been implicated in modulating fear, the potential for incerto-thalamic pathways to suppress fear generalization and rescue deficits in extinction recall remains unexplored. We first used patch-clamp electrophysiology to examine functional connections between the subthalamic zona incerta and thalamic reuniens (RE). Optogenetic stimulation of GABAergic ZI → RE cell terminals in vitro induced inhibitory post-synaptic currents (IPSCs) in the RE. We then combined high-intensity discriminative auditory fear conditioning with cell-type-specific and projection-specific optogenetics in mice to assess functional roles of GABAergic ZI → RE cell projections in modulating fear generalization and extinction recall. In addition, we used a similar approach to test the possibility of fear generalization and extinction recall being modulated by a smaller subset of GABAergic ZI → RE cells, the A13 dopaminergic cell population. Optogenetic stimulation of GABAergic ZI → RE cell terminals attenuated fear generalization and enhanced extinction recall. In contrast, optogenetic stimulation of dopaminergic ZI → RE cell terminals had no effect on fear generalization but enhanced extinction recall in a dopamine receptor D1-dependent manner. Our findings shed new light on the neuroanatomy and neurochemistry of ZI-located cells that contribute to adaptive fear by increasing the precision and extinction of learned associations. In so doing, these data reveal novel neuroanatomical substrates that could be therapeutically targeted for treatment of PTSD.

scholarly journals Neural Substrates of Human Fear Generalization: A 7T-fMRI Investigation

NeuroImage ◽  
2021 ◽  
pp. 118308
Author(s):  
Ashley A. Huggins ◽  
Carissa N. Weis ◽  
Elizabeth A. Parisi ◽  
Kenneth P. Bennett ◽  
Vladimir Miskovic ◽  
...  
Keyword(s):  
Neural Substrates ◽  
Fear Generalization ◽  
7T Fmri
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