Anterior insula activity and the effect of agency on the Stimulus‐Preceding Negativity

2020 ◽  
Vol 57 (4) ◽  
Author(s):  
Steven A. Hackley ◽  
Takahiro Hirao ◽  
Keiichi Onoda ◽  
Keiko Ogawa ◽  
Hiroaki Masaki
Keyword(s):  
Anterior Insula ◽  
Stimulus Preceding Negativity

A common role for anterior insula in emotion and attention

2011 ◽  
Author(s):  
Alexandra Touroutoglou ◽  
Lisa Feldman Barrett
Keyword(s):  
Anterior Insula

Dysphagia due to unilateral infarction within the anterior insula

2008 ◽  
Vol 35 (S 01) ◽  
Author(s):  
R Gastl ◽  
P Kühnlein ◽  
M Prosiegel ◽  
A Riecker
Keyword(s):  
Anterior Insula

The role of anterior insula–brainstem projections and alpha-1 noradrenergic receptors for compulsion-like and alcohol-only drinking

2021 ◽  
Author(s):  
Thatiane De Oliveira Sergio ◽  
Kelly Lei ◽  
Claudina Kwok ◽  
Shahbaj Ghotra ◽  
Scott A. Wegner ◽  
...  
Keyword(s):  
Anterior Insula ◽  
Noradrenergic Receptors

scholarly journals Diagnostic Task Specific Activations in Functional MRI and Aberrant Connectivity of Insula with Middle Frontal Gyrus Can Inform the Differential Diagnosis of Psychosis

Diagnostics ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 95
Author(s):  
Drozdstoy Stoyanov ◽  
Katrin Aryutova ◽  
Sevdalina Kandilarova ◽  
Rositsa Paunova ◽  
Zlatoslav Arabadzhiev ◽  
...  
Keyword(s):  
Effective Connectivity ◽  
Paranoid Schizophrenia ◽  
Indirect Evidence ◽  
Inhibitory Effect ◽  
Posterior Cingulate Cortex ◽  
Anterior Insula ◽  
Middle Frontal Gyrus ◽  
Angular Gyrus ◽  
Inhibitory Connection ◽  
Significant Difference

We constructed a novel design integrating the administration of a clinical self-assessment scale with simultaneous acquisition of functional Magnetic Resonance Imaging (fMRI), aiming at cross-validation between psychopathology evaluation and neuroimaging techniques. We hypothesized that areas demonstrating differential activation in two groups of patients (the first group exhibiting paranoid delusions in the context of paranoid schizophrenia—SCH—and second group with a depressive episode in the context of major depressive disorder or bipolar disorder—DEP) will have distinct connectivity patterns and structural differences. Fifty-one patients with SCH (n = 25) or DEP (n = 26) were scanned with three different MRI sequences: a structural and two functional sequences—resting-state and task-related fMRI (the stimuli represent items from a paranoid-depressive self-evaluation scale). While no significant differences were found in gray matter volumes, we were able to discriminate between the two clinical entities by identifying two significant clusters of activations in the SCH group—the left Precuneus (PreCu) extending to the left Posterior Cingulate Cortex (PCC) and the right Angular Gyrus (AG). Additionally, the effective connectivity of the middle frontal gyrus (MFG), a part of the Dorsolateral Prefrontal Cortex (DLPFC) to the Anterior Insula (AI), demonstrated a significant difference between the two groups with inhibitory connection demonstrated only in SCH. The observed activations of PreCu, PCC, and AG (involved in the Default Mode Network DMN) might be indirect evidence of the inhibitory connection from the DLPFC to AI, interfering with the balancing function of the insula as the dynamic switch in the DMN. The findings of our current study might suggest that the connectivity from DLPFC to the anterior insula can be interpreted as evidence for the presence of an aberrant network that leads to behavioral abnormalities, the manifestation of which depends on the direction of influence. The reduced effective connectivity from the AI to the DLPFC is manifested as depressive symptoms, and the inhibitory effect from the DLPFC to the AI is reflected in the paranoid symptoms of schizophrenia.

scholarly journals Comparison of structural covariance with functional connectivity approaches exemplified by an investigation of the left anterior insula

NeuroImage ◽  
2014 ◽  
Vol 99 ◽  
pp. 269-280 ◽  
Author(s):  
Mareike Clos ◽  
Claudia Rottschy ◽  
Angela R. Laird ◽  
Peter T. Fox ◽  
Simon B. Eickhoff
Keyword(s):  
Functional Connectivity ◽  
Anterior Insula ◽  
Structural Covariance

Self-regulation of the anterior insula: Reinforcement learning using real-time fMRI neurofeedback

NeuroImage ◽  
2014 ◽  
Vol 88 ◽  
pp. 113-124 ◽  
Author(s):  
Emma J. Lawrence ◽  
Li Su ◽  
Gareth J. Barker ◽  
Nick Medford ◽  
Jeffrey Dalton ◽  
...  
Keyword(s):  
Reinforcement Learning ◽  
Real Time ◽  
Self Regulation ◽  
Anterior Insula

Anesthesia-induced Suppression of Human Dorsal Anterior Insula Responsivity at Loss of Volitional Behavioral Response

2016 ◽  
Vol 124 (4) ◽  
pp. 766-778 ◽  
Author(s):  
Catherine Elizabeth Warnaby ◽  
Marta Seretny ◽  
Roísín Ní Mhuircheartaigh ◽  
Richard Rogers ◽  
Saad Jbabdi ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Anterior Insula ◽  
Cortical Region ◽  
Dorsolateral Prefrontal ◽  
Behavioral Responsiveness ◽  
Insula Cortex ◽  
Evoked Activity ◽  
The Right ◽  
Conjunction Analysis ◽  
External Stimuli

Abstract Background It has been postulated that a small cortical region could be responsible for the loss of behavioral responsiveness (LOBR) during general anesthesia. The authors hypothesize that any brain region demonstrating reduced activation to multisensory external stimuli around LOBR represents a key cortical gate underlying this transition. Furthermore, the authors hypothesize that this localized suppression is associated with breakdown in frontoparietal communication. Methods During both simultaneous electroencephalography and functional magnetic resonance imaging (FMRI) and electroencephalography data acquisition, 15 healthy volunteers experienced an ultraslow induction with propofol anesthesia while a paradigm of multisensory stimulation (i.e., auditory tones, words, and noxious pain stimuli) was presented. The authors performed separate analyses to identify changes in (1) stimulus-evoked activity, (2) functional connectivity, and (3) frontoparietal synchrony associated with LOBR. Results By using an FMRI conjunction analysis, the authors demonstrated that stimulus-evoked activity was suppressed in the right dorsal anterior insula cortex (dAIC) to all sensory modalities around LOBR. Furthermore, the authors found that the dAIC had reduced functional connectivity with the frontoparietal regions, specifically the dorsolateral prefrontal cortex and inferior parietal lobule, after LOBR. Finally, reductions in the electroencephalography power synchrony between electrodes located in these frontoparietal regions were observed in the same subjects after LOBR. Conclusions The authors conclude that the dAIC is a potential cortical gate responsible for LOBR. Suppression of dAIC activity around LOBR was associated with disruption in the frontoparietal networks that was measurable using both electroencephalography synchrony and FMRI connectivity analyses.

Altered resting state functional connectivity of anterior insula in young smokers

2016 ◽  
Vol 11 (1) ◽  
pp. 155-165 ◽  
Author(s):  
Yanzhi Bi ◽  
Kai Yuan ◽  
Yanyan Guan ◽  
Jiadong Cheng ◽  
Yajuan Zhang ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Anterior Insula ◽  
Resting State Functional Connectivity ◽  
Young Smokers

scholarly journals The Neural Sociometer: Brain Mechanisms Underlying State Self-esteem

2011 ◽  
Vol 23 (11) ◽  
pp. 3448-3455 ◽  
Author(s):  
Naomi I. Eisenberger ◽  
Tristen K. Inagaki ◽  
Keely A. Muscatell ◽  
Kate E. Byrne Haltom ◽  
Mark R. Leary
Keyword(s):  
Negative Feedback ◽  
Cortical Activity ◽  
Self Esteem ◽  
Anterior Insula ◽  
Lower State ◽  
Social Connection ◽  
Prefrontal Cortical ◽  
Referential Processing ◽  
Neural Underpinnings ◽  
Medial Prefrontal Cortical

On the basis of the importance of social connection for survival, humans may have evolved a “sociometer”—a mechanism that translates perceptions of rejection or acceptance into state self-esteem. Here, we explored the neural underpinnings of the sociometer by examining whether neural regions responsive to rejection or acceptance were associated with state self-esteem. Participants underwent fMRI while viewing feedback words (“interesting,” “boring“) ostensibly chosen by another individual (confederate) to describe the participant's previously recorded interview. Participants rated their state self-esteem in response to each feedback word. Results demonstrated that greater activity in rejection-related neural regions (dorsal ACC, anterior insula) and mentalizing regions was associated with lower-state self-esteem. Additionally, participants whose self-esteem decreased from prescan to postscan versus those whose self-esteem did not showed greater medial prefrontal cortical activity, previously associated with self-referential processing, in response to negative feedback. Together, the results inform our understanding of the origin and nature of our feelings about ourselves.

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