scholarly journals Resting state connectivity of the medial prefrontal cortex covaries with individual differences in high-frequency heart rate variability

2015 ◽  
Vol 53 (4) ◽  
pp. 444-454 ◽  
Author(s):  
J. Richard Jennings ◽  
Lei K. Sheu ◽  
Dora C-H. Kuan ◽  
Stephen B. Manuck ◽  
Peter J. Gianaros
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Prefrontal Cortex ◽  
Individual Differences ◽  
Medial Prefrontal Cortex ◽  
Resting State ◽  
High Frequency ◽  
Resting State Connectivity

Heart rate variability interacts with recovery of resting-state connectivity in amygdala circuitry and the persistence of symptoms after sport-related concussion

Neurology ◽  
2020 ◽  
Vol 95 (20 Supplement 1) ◽  
pp. S15.2-S16
Author(s):  
Kevin Bickart ◽  
Christopher Andrew Sheridan ◽  
Corey M. Thibeault ◽  
Robert Hamilton ◽  
James LeVangie ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Resting State ◽  
Autonomic Function ◽  
Network Connectivity ◽  
Resting State Fmri ◽  
Network Recovery ◽  
Symptom Persistence ◽  
Resting State Connectivity ◽  
Over Time

ObjectiveWe investigated longitudinal trajectories of resting-state fMRI (rsfMRI), autonomic function, and graded symptoms after sport-related concussion (SRC).BackgroundLimbic circuitry may be particularly vulnerable to traumatic brain injury, which could explain the affective and autonomic dysfunction that some patients develop. Relatively few studies have performed longitudinal rsfMRI analyses in concussion and fewer have combined imaging with autonomic and symptom data. We leveraged published limbic rsfMRI networks centered on the amygdala that include core affective and autonomic structures to test whether athletes with SRC would have altered connectivity, and that network recovery would be related to measures of autonomic function and symptom persistence.Design/MethodsWe compared rsfMRI connectivity of amygdala networks in college athletes with SRC (N = 31, female = 14) at three time points after concussion (T1 = 4 days, T2 = 10–14 days, T3 = 2–3 months) and matched controls with no concussion (in-sport control [ISC] N = 36, female = 17).ResultsSRCs show greater amygdala network connectivity as compared to ISCs (T1 p = 0.003, T2 p = 0.014) that normalizes over time (T3 p = 0.182). However, SRCs with higher versus lower heart rate variability (HRV), as measured by pNN50 at T1, have opposing trajectories of connectivity. That is, SRCs with higher HRV have connectivity that starts high and normalizes over time (T1 p = 0.001, T2 p = 0.055, T3 p = 0.576) whereas SRCs with lower HRV have connectivity that increases over time (T1 p = 0.429, T2 p = 0.050, T3 p = 0.002). Furthermore, SRCs with greatest connectivity at T3, presumably the least recovered, have the most symptoms on the Graded Symptom Checklist at ∼3 months (r = 0.635, p = 0.001).ConclusionsHeightened connectivity of amygdala circuitry acutely after a concussion and its normalization over time may be protective, and with HRV, may be a biomarker of symptom persistence.

A Meta-analysis on Resting State High-frequency Heart Rate Variability in Bulimia Nervosa

2016 ◽  
Vol 24 (5) ◽  
pp. 355-365 ◽  
Author(s):  
Stephanie K. V. Peschel ◽  
Nicole R. Feeling ◽  
Claus Vögele ◽  
Michael Kaess ◽  
Julian F. Thayer ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Bulimia Nervosa ◽  
Resting State ◽  
High Frequency ◽  
Meta Analysis

The association between individual differences in executive functioning and resting high-frequency heart rate variability

2019 ◽  
Vol 148 ◽  
pp. 107772 ◽  
Author(s):  
Paula G. Williams ◽  
Matthew R. Cribbet ◽  
Ruben Tinajero ◽  
Holly K. Rau ◽  
Julian F. Thayer ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Individual Differences ◽  
Executive Functioning ◽  
High Frequency

scholarly journals The influence of heart rate variability biofeedback on cardiac regulation and functional brain connectivity

2020 ◽  
Author(s):  
Andy Schumann ◽  
Feliberto de la Cruz ◽  
Stefanie Köhler ◽  
Lisa Brotte ◽  
Karl-Jürgen Bär
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Prefrontal Cortex ◽  
Functional Connectivity ◽  
Resting State ◽  
Brain Connectivity ◽  
Brain Regions ◽  
Anterior Insula ◽  
Control Group ◽  
Functional Brain

AbstractBackgroundHeart rate variability (HRV) biofeedback has a beneficial impact on perceived stress and emotion regulation. However, its impact on brain function is still unclear. In this study, we aimed to investigate the effect of an 8-week HRV-biofeedback intervention on functional brain connectivity in healthy subjects.MethodsHRV biofeedback was carried out in five sessions per week, including four at home and one in our lab. A control group played jump‘n’run games instead of the training. Functional magnetic resonance imaging was conducted before and after the intervention in both groups. To compute resting state functional connectivity (RSFC), we defined regions of interest in the ventral medial prefrontal cortex (VMPFC) and a total of 260 independent anatomical regions for network-based analysis. Changes of RSFC of the VMPFC to other brain regions were compared between groups. Temporal changes of HRV during the resting state recording were correlated to dynamic functional connectivity of the VMPFC.ResultsFirst, we corroborated the role of the VMPFC in cardiac autonomic regulation. We found that temporal changes of HRV were correlated to dynamic changes of prefrontal connectivity, especially to the middle cingulate cortex, left anterior insula, right amygdala, supplementary motor area, dorsal and ventral lateral prefrontal regions. The biofeedback group showed a drop in heart rate by 5.5 beats/min and an increased RMSSD as a measure of HRV by 10.1ms (33%) after the intervention. Functional connectivity of the VMPFC increased mainly to the right anterior insula, the dorsal anterior cingulate cortex and the dorsolateral prefrontal cortex after biofeedback intervention when compared to changes in the control group. Network-based statistic showed that biofeedback had an influence on a broad functional network of brain regions.ConclusionOur results show that increased vagal modulation induced by HRV-biofeedback is accompanied by changes in functional brain connectivity during resting state.

scholarly journals Altered ventral striatal–medial prefrontal cortex resting-state connectivity mediates adolescent social problems after early institutional care

2017 ◽  
Vol 29 (5) ◽  
pp. 1865-1876 ◽  
Author(s):  
Dominic S. Fareri ◽  
Laurel Gabard-Durnam ◽  
Bonnie Goff ◽  
Jessica Flannery ◽  
Dylan G. Gee ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Resting State ◽  
Social Problems ◽  
Ventral Striatum ◽  
Institutional Care ◽  
Increased Risk ◽  
Social Difficulties ◽  
Institutionalized Youth ◽  
Resting State Connectivity

AbstractEarly caregiving adversity is associated with increased risk for social difficulties. The ventral striatum and associated corticostriatal circuitry, which have demonstrated vulnerability to early exposures to adversity, are implicated in many aspects of social behavior, including social play, aggression, and valuation of social stimuli across development. Here, we used resting-state functional magnetic resonance imaging to assess the degree to which early caregiving adversity was associated with altered coritocostriatal resting connectivity in previously institutionalized youth (n = 41) relative to youth who were raised with their biological families from birth (n = 47), and the degree to which this connectivity was associated with parent-reported social problems. Using a seed-based approach, we observed increased positive coupling between the ventral striatum and anterior regions of medial prefrontal cortex (mPFC) in previously institutionalized youth. Stronger ventral striatum–mPFC coupling was associated with parent reports of social problems. A moderated-mediation analysis showed that ventral striatal–mPFC connectivity mediated group differences in social problems, and more so with increasing age. These findings show that early institutional care is associated with differences in resting-state connectivity between the ventral striatum and the mPFC, and this connectivity seems to play an increasingly important role in social behaviors as youth enter adolescence.

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