scholarly journals Cardiac stability at differing levels of temporal analysis in panic disorder, post-traumatic stress disorder, and healthy controls

2013 ◽  
Vol 51 (1) ◽  
pp. 80-87 ◽  
Author(s):  
Aaron J. Fisher ◽  
Steven H. Woodward
2018 ◽  
Vol 12 (1) ◽  
pp. 42-54 ◽  
Author(s):  
Andrew A. Fingelkurts ◽  
Alexander A. Fingelkurts

Background and Objective:Understanding how trauma impacts the self-structure of individuals suffering from the Post-Traumatic Stress Disorder (PTSD) symptoms is a complex matter and despite several attempts to explain the relationship between trauma and the “Self”, this issue still lacks clarity. Therefore, adopting a new theoretical perspective may help understand PTSD deeper and to shed light on the underlying psychophysiological mechanisms.Methods:In this study, we employed the “three-dimensional construct model of the experiential selfhood” where three major components of selfhood (phenomenal first-person agency, embodiment, and reflection/narration) are related to three Operational Modules (OMs) of the self-referential brain network. These modules can be reliably estimated through operational synchrony analysis of the Electroencephalogram (EEG). Six individuals with PTSD symptoms and twenty-nine sex-, age- and demographic- (race, education, marital status) matched healthy controls underwent resting state EEG signal acquisition with the following estimation of the synchrony strength within every OM.Results:Our results indicate that subjects with PTSD symptoms had significantly stronger EEG operational synchrony within anterior and right posterior OMs as well as significantly weaker EEG operational synchrony within left posterior OM compared to healthy controls. Moreover, increased the functional integrity of the anterior OM was positively associated with hyperactivity symptoms, reduced synchrony of the left posterior OM was associated with greater avoidance, and increased right posterior OM integrity was positively correlated with intrusion and mood symptoms.Conclusion:The results are interpreted in light of the triad model of selfhood and its theoretical and clinical implications (including a new treatment approach) are discussed.


2011 ◽  
Vol 26 (S2) ◽  
pp. 168-168
Author(s):  
C. Muhtz ◽  
J. Daneshi ◽  
M. Braun ◽  
M. Kellner

IntroductionPanic disorder and post-traumatic stress disorder (PTSD), which is currently classified as an anxiety disorder in DSM-IV, share some clinical characteristics. Emerging evidence suggests that CO2-induced fear reactivity is associated with anxiety disorders, especially panic disorder. However, there are only very few data available about the sensitivity of patients with PTSD to carbon dioxide.AimTo examine the psychometric effects of CO2 on panic anxiety and PTSD symptoms in subjects with PTSD.MethodsIn 10 patients with PTSD, 10 sex- and age-matched healthy subjects and additional 8 patients with panic disorder we assessed anxiety, panic, dissociative and PTSD symptoms before and after a single vital capacity inhalation of 35% CO2.ResultsInhalation of a single deep breath of 35% of carbon dioxide resulted in significant panicogenic and anxiogenic effects in PTSD patients versus healthy controls, which were similar to the well known responses of patients with panic disorder. Furthermore, significant pro-dissociative effects and significant provocation of post-traumatic flashbacks and PTSD symptoms were observed in PTSD patients.ConclusionsThese data provide novel evidence that panic disorder and PTSD share a common hypersensitivity to CO2 and thus might belong to the same spectrum of vulnerability.


2018 ◽  
Vol 32 (2) ◽  
pp. 43-52 ◽  
Author(s):  
Andrea C. Katz ◽  
Anna Weinberg ◽  
Stephanie M. Gorka ◽  
Randy P. Auerbach ◽  
Stewart A. Shankman

Abstract. Although panic disorder (PD) and post-traumatic stress disorder (PTSD) are characterized by heightened sensitivity to threat, no study to date has examined the effect of comorbid PD and PTSD on defensive responding. The present study probed startle eyeblink response to an acoustic probe in three groups of participants recruited from the community: (1) healthy individuals (n = 63), (2) individuals with PD without PTSD (n = 62), and (3) individuals with comorbid PD and PTSD (n = 24). Results indicated that PD individuals without PTSD exhibited greater sensitivity to threat relative to controls, and comorbid individuals displayed attenuated sensitivity to threat relative to PD individuals without PTSD (both ps < .05). The results are discussed in the context of the anxiety disorder spectrum, which postulates that anxiety disorders exist on a continuum spanning from specific/simple fear to broad distress, with defensive responding decreasing as distress increases.


2021 ◽  
Author(s):  
Daniele Ferrarese ◽  
Giorgia Spagnolo ◽  
Michele Vecchione ◽  
Franco Scaldaferri ◽  
Alessandro Armuzzi ◽  
...  

Background. Several psychological disorders have been described in patients affected by Inflammatory Bowel Disease (IBD). Few studies have focused on the relationship between IBD and Post-Traumatic Stress Disorder (PTSD) symptoms, and no data are available on the relationship between IBD and dissociative symptoms. Aim of the present study was to evaluate the prevalence of PTSD and dissociative symptoms in a sample of IBD patients compared to healthy controls. A possible relationship with disease activity was also investigated. Methods: A total of 112 IBD patients, 55 Crohn’s disease (CD) and 57 Ulcerative Colitis (UC), and 114 healthy individuals were evaluated. IBD patients were divided into three subgroups according to disease activity (remission, mild, moderate). The revised version of the Impact of Event Scale (IES-R) and the Dissociative Experience Scale (DES) were administered to patients and controls. Results: IBD patients showed significantly higher rates of PTSD and dissociative symptoms compared to healthy controls. No differences were found between CD and UC patients. PTSD and dissociative symptoms were higher among CD patients with mild to moderate-severe activity compared to the remission group. No differences were found among UC patients with different activity levels. Conclusion: IBD patients show a high prevalence of dissociative and traumatic affective disorders. Future studies are needed to investigate the role of these disorders in the clinical course and management of IBD patients according to different disease activity phase.


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