Progression of logopenic aphasia to frontotemporal dementia in an amyloid β-negative and 18 F-THK-5351-positive patient

2019 ◽  
Vol 19 (4) ◽  
pp. 399-401 ◽  
Author(s):  
Masahiko Takaya ◽  
Kazunari Ishii ◽  
Isao Kubota ◽  
Osamu Shirakawa
Keyword(s):  
Frontotemporal Dementia ◽  
Amyloid Β ◽  
Positive Patient ◽  
Logopenic Aphasia

scholarly journals Correction to: Cerebrospinal fluid amyloid-β 2-42 is decreased in Alzheimer’s, but not in frontotemporal dementia

2018 ◽  
Vol 125 (10) ◽  
pp. 1515-1516 ◽  
Author(s):  
Mirko Bibl ◽  
Marion Gallus ◽  
Volker Welge ◽  
Hermann Esselmann ◽  
Stefanie Wolf ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Frontotemporal Dementia ◽  
Amyloid Β

Soluble amyloid β-protein is increased in frontotemporal dementia with tau gene mutations

2004 ◽  
Vol 6 (1) ◽  
pp. 45-51 ◽  
Author(s):  
Antonella Vitali ◽  
Alessandra Piccini ◽  
Roberta Borghi ◽  
Pantaleo Fornaro ◽  
Sandra L. Siedlak ◽  
...  
Keyword(s):  
Frontotemporal Dementia ◽  
Gene Mutations ◽  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Β Protein

scholarly journals IC-P1-030: Does Amyloid β accumulation modify clinical feature of frontotemporal dementia?

2008 ◽  
Vol 4 ◽  
pp. T20-T21
Author(s):  
Kenji Ishii ◽  
Kiichi Ishiwata ◽  
Keiichi Oda ◽  
Yuichi Kimura ◽  
Muneyuki Sakata ◽  
...  
Keyword(s):  
Frontotemporal Dementia ◽  
Amyloid Β ◽  
Clinical Feature

scholarly journals ApoE4 lowers age at onset in patients with frontotemporal dementia and tauopathy independent of amyloid‐β copathology

2019 ◽  
Vol 11 (1) ◽  
pp. 277-280 ◽  
Author(s):  
Carolin Koriath ◽  
Tammaryn Lashley ◽  
William Taylor ◽  
Ronald Druyeh ◽  
Athanasios Dimitriadis ◽  
...  
Keyword(s):  
Frontotemporal Dementia ◽  
Age At Onset ◽  
Amyloid Β

scholarly journals The Landscape Montage Technique for diagnosing frontotemporal dementia starting as primary progressive aphasia: a case report

2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Masahiko Takaya ◽  
Kazunari Ishii ◽  
Isao Kubota ◽  
Osamu Shirakawa
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Frontotemporal Dementia ◽  
Primary Progressive Aphasia ◽  
Language Test ◽  
Behavioral Variant Frontotemporal Dementia ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Logopenic Aphasia

Abstract Background The Landscape Montage Technique was originally developed by Hisao Nakai, a Japanese psychiatrist, to pursue the possibility and application of a psychotherapeutic approach using drawing for patients with schizophrenia. Drawing was initially adopted to evaluate patients with an impaired ability for verbal expression, particularly for the diagnosis and treatment of patients with schizophrenia. Since its development, the Landscape Montage Technique has been utilized in various clinical settings throughout Japan. This study aimed to evaluate the psychiatric conditions of a patient diagnosed as having primary progressive aphasia using the Landscape Montage Technique at a 3-year follow-up. Case presentation We present the case of a 64-year-old, right-handed Japanese woman initially diagnosed as having logopenic variant primary progressive aphasia or logopenic aphasia. At a 3-year follow-up, logopenic aphasia progressed to behavioral variant frontotemporal dementia or frontotemporal dementia. According to her husband, she began to have speech difficulties approximately 5 years before her first visit. The results of neurocognitive tests suggested mild cognitive impairment or early stages of dementia. Her clinical dementia rating score was 0.5, suggesting a diagnosis of mild cognitive impairment. She had a Raven’s Colored Progressive Matrices score of 31 out of 36, which indicated a nonverbal cognitive ability that was greater than the 90th percentile for her age. The Japanese Standard Language Test of Aphasia, which was performed at two points during the follow-up, indicated the possibility for a diagnosis of primary progressive aphasia given the progression of her aphasia. Based on her clinical symptoms and Japanese Standard Language Test of Aphasia results, a diagnosis of logopenic variant primary progressive aphasia was established. Magnetic resonance imaging revealed severe predominant left frontal and anterior temporal atrophy, as well as bilateral parietal atrophy. Amyloid beta deposition was negative. At the 3-year follow-up, logopenic variant primary progressive aphasia had progressed to behavioral variant frontotemporal dementia. However, the Landscape Montage Technique allowed for the diagnosis of behavioral variant frontotemporal dementia only 2 years after baseline. Conclusions The present study showed that the Landscape Montage Technique can be useful for diagnosing behavioral variant frontotemporal dementia that starts as logopenic variant primary progressive aphasia at earlier stages.

scholarly journals Assessment of amyloid β in pathologically confirmed frontotemporal dementia syndromes

2017 ◽  
Vol 9 (1) ◽  
pp. 10-20 ◽  
Author(s):  
Rachel H. Tan ◽  
Jillian J. Kril ◽  
Yue Yang ◽  
Nicole Tom ◽  
John R. Hodges ◽  
...  
Keyword(s):  
Frontotemporal Dementia ◽  
Amyloid Β

scholarly journals Cerebrospinal fluid amyloid-β 2-42 is decreased in Alzheimer’s, but not in frontotemporal dementia

2012 ◽  
Vol 119 (7) ◽  
pp. 805-813 ◽  
Author(s):  
Mirko Bibl ◽  
Marion Gallus ◽  
Volker Welge ◽  
Hermann Esselmann ◽  
Stefanie Wolf ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Frontotemporal Dementia ◽  
Amyloid Β

scholarly journals Animal Models for Alzheimer's Disease and Frontotemporal Dementia: A Perspective

ASN NEURO ◽  
2009 ◽  
Vol 1 (4) ◽  
pp. AN20090042 ◽  
Author(s):  
Jürgen Götz ◽  
Naeman N Götz
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Animal Models ◽  
Frontotemporal Dementia ◽  
Amyloid Β ◽  
Human Condition ◽  
Aβ Amyloid ◽  
Dementia Research ◽  
Insight Into ◽  
Research Animal

In dementia research, animal models have become indispensable tools. They not only model aspects of the human condition, but also simulate processes that occur in humans and hence provide insight into how disease is initiated and propagated. The present review discusses two prominent human neurodegenerative disorders, Alzheimer's disease and frontotemporal dementia. It discusses what we would like to model in animals and highlights some of the more recent achievements using species as diverse as mice, fish, flies and worms. Advances in imaging and therapy are explored. We also discuss some anticipated new models and developments. These will reveal how key players in the pathogenesis of Alzheimer's disease and frontotemporal dementia, such as the peptide Aβ (amyloid β) and the protein tau, cause neuronal dysfunction and eventually, neuronal demise. Understanding these processes fully will lead to early diagnosis and therapy.

CSF Tau, phospho-Tau181 and amyloid-β 38/40/42 in frontotemporal dementia and pimary progressive aphasia

2009 ◽  
Vol 36 (S 02) ◽  
Author(s):  
A Hofmann ◽  
V Welge ◽  
O Fiege ◽  
P Lewczuk ◽  
S Wolf ◽  
...  
Keyword(s):  
Frontotemporal Dementia ◽  
Amyloid Β ◽  
Progressive Aphasia

P1-250: Does Amyloid-β accumulation modify clinical features of frontotemporal dementia?

2008 ◽  
Vol 4 ◽  
pp. T288-T289 ◽  
Author(s):  
Kenji Ishii ◽  
Kiichi Ishiwata ◽  
Keiichi Oda ◽  
Yuichi Kimura ◽  
Muneyuki Sakata ◽  
...  
Keyword(s):  
Frontotemporal Dementia ◽  
Clinical Features ◽  
Amyloid Β
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