Lack of association between apolipoprotein E genotypes and cognitive performance in the non-demented elderly

2013 ◽  
Vol 14 (1) ◽  
pp. 11-16 ◽  
Author(s):  
Juliana Lima Quintas ◽  
Vinícius Carolino Souza ◽  
Adriane Dallanora Henriques ◽  
Wilcelly Machado-Silva ◽  
Juliana Oliveira Toledo ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Cognitive Performance ◽  
Apolipoprotein E Genotypes

Lower cerebral oxygen utilization is associated with Alzheimer’s disease-related neurodegeneration and poorer cognitive performance among apolipoprotein E ε4 carriers

2021 ◽  
pp. 0271678X2110563
Author(s):  
W Hudson Robb ◽  
Omair A Khan ◽  
Humza A Ahmed ◽  
Judy Li ◽  
Elizabeth E Moore ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Episodic Memory ◽  
Apolipoprotein E ◽  
Cognitive Performance ◽  
Lateral Ventricle ◽  
Oxygen Metabolism ◽  
Cerebral Oxygen ◽  
P Values ◽  
Apoe Ε4

Oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2) are markers of cerebral oxygen homeostasis and metabolism that may offer insights into abnormal changes in brain aging. The present study cross-sectionally related OEF and CMRO2 to cognitive performance and structural neuroimaging variables among older adults (n = 246, 74 ± 7 years, 37% female) and tested whether apolipoprotein E ( APOE)-ε4 status modified these associations. Main effects of OEF and CMRO2 were null (p-values >0.06), and OEF interactions with APOE-ε4 status on cognitive and structural imaging outcomes were null (p-values >0.06). However, CMRO2 interacted with APOE-ε4 status on language (p = 0.002), executive function (p = 0.03), visuospatial (p = 0.005), and episodic memory performances (p = 0.03), and on hippocampal (p = 0.006) and inferior lateral ventricle volumes (p = 0.02). In stratified analyses, lower oxygen metabolism related to worse language (p = 0.02) and episodic memory performance (p = 0.03) among APOE-ε4 carriers only. Associations between CMRO2 and cognitive performance were primarily driven by APOE-ε4 carriers with existing cognitive impairment. Congruence across language and episodic memory results as well as hippocampal and inferior lateral ventricle volume findings suggest that APOE-ε4 may interact with cerebral oxygen metabolism in the pathogenesis of Alzheimer’s disease and related neurodegeneration.

Apolipoprotein E genotypes in offspring with a positive and negative family history of premature myocardial infarction

2008 ◽  
Vol 53 (5) ◽  
pp. 387-390 ◽  
Author(s):  
Katarina Rašlová ◽  
Božena Smolková ◽  
Branislav Vohnout ◽  
Branislav Schifferdecker ◽  
Rudolf Poledne ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Family History ◽  
Apolipoprotein E ◽  
Negative Family History ◽  
Apolipoprotein E Genotypes ◽  
History Of ◽  
Premature Myocardial Infarction

Lower Cognitive Performance of Older Football Players Possessing Apolipoprotein E ε4

Neurosurgery ◽  
2000 ◽  
Vol 47 (3) ◽  
pp. 651-658 ◽  
Author(s):  
Kenneth C. Kutner ◽  
David M. Erlanger ◽  
Julia Tsai ◽  
Barry Jordan ◽  
Norman R. Relkin
Keyword(s):  
Apolipoprotein E ◽  
Cognitive Performance ◽  
Football Players

Relationship between adipokines and lipid profile in postmenopausal women with different apolipoprotein E genotypes

2016 ◽  
Vol 57 (8) ◽  
pp. 891-904 ◽  
Author(s):  
Magdalena Gibas-Dorna ◽  
Jacek Piątek ◽  
Justyna Kupsz ◽  
Malgorzata Bernatek ◽  
Hanna Krauss ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Lipid Profile ◽  
Postmenopausal Women ◽  
Apolipoprotein E Genotypes

Association of apolipoprotein E genotypes with epilepsy risk: A systematic review and meta-analysis

2019 ◽  
Vol 98 ◽  
pp. 27-35
Author(s):  
Yifan Liang ◽  
Zhike Zhou ◽  
Huibin Wang ◽  
Xi Cheng ◽  
Shanshan Zhong ◽  
...  
Keyword(s):  
Systematic Review ◽  
Apolipoprotein E ◽  
Meta Analysis ◽  
Apolipoprotein E Genotypes
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