Paradigm shift in the pathogenesis and treatment of oral cancer and other cancers focused on the oralome and antimicrobial‐based therapeutics

Allan Radaic; Sean Ganther; Pachiyappan Kamarajan; Jennifer Grandis; Sue S. Yom; Yvonne L. Kapila

doi:10.1111/prd.12388

Paradigm shift in the pathogenesis and treatment of oral cancer and other cancers focused on the oralome and antimicrobial‐based therapeutics

Periodontology 2000 ◽

10.1111/prd.12388 ◽

2021 ◽

Vol 87 (1) ◽

pp. 76-93

Author(s):

Allan Radaic ◽

Sean Ganther ◽

Pachiyappan Kamarajan ◽

Jennifer Grandis ◽

Sue S. Yom ◽

...

Keyword(s):

Oral Cancer ◽

Paradigm Shift

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Paradigm shift in approach to potentially malignant disorders and oral cancer

Journal of Advanced Clinical and Research Insights ◽

10.15713/ins.jcri.163 ◽

2017 ◽

Vol 4 (3) ◽

pp. 78-78

Author(s):

Dr. Vishwanath Rangdhol

Keyword(s):

Oral Cancer ◽

Paradigm Shift ◽

Potentially Malignant Disorders ◽

Potentially Malignant

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Ultrastructural features of prognostic significance in human oral cancer

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100123490 ◽

1992 ◽

Vol 50 (1) ◽

pp. 618-619

Author(s):

Karvita B. Ahluwalia ◽

Nidhi Sharma

Keyword(s):

Oral Cancer ◽

Squamous Cell ◽

Common Knowledge ◽

Prognostic Significance ◽

Growth Control ◽

Terminal Differentiation ◽

Squamous Cell Carcinomas ◽

Effective Therapy ◽

Invasive Potential ◽

Biological Behaviour

It is common knowledge that apparently similar tumors often show different responses to therapy. This experience has generated the idea that histologically similar tumors could have biologically distinct behaviour. The development of effective therapy therefore, has the explicit challenge of understanding biological behaviour of a tumor. The question is which parameters in a tumor could relate to its biological behaviour ? It is now recognised that the development of malignancy requires an alteration in the program of terminal differentiation in addition to aberrant growth control. In this study therefore, ultrastructural markers that relate to defective terminal differentiation and possibly invasive potential of cells have been identified in human oral leukoplakias, erythroleukoplakias and squamous cell carcinomas of the tongue.

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