scholarly journals Association between metabolic syndrome and periodontitis: The role of lipids, inflammatory cytokines, altered host response, and the microbiome

2021 ◽  
Vol 87 (1) ◽  
pp. 50-75
Author(s):  
Flavia Q. Pirih ◽  
Sepehr Monajemzadeh ◽  
Neelima Singh ◽  
Rachel Sheridan Sinacola ◽  
Jae Min Shin ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Inflammatory Cytokines ◽  
Host Response

scholarly journals The transcription factor KLF14 regulates macrophage glycolysis and immune function by inhibiting HK2 in sepsis

2022 ◽  
Author(s):  
Yuan Yuan ◽  
Guangjian Fan ◽  
Yuqi Liu ◽  
Lu Liu ◽  
Tong Zhang ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Immune Function ◽  
Signaling Pathway ◽  
Inflammatory Cytokines ◽  
Host Response ◽  
Targeted Therapeutics ◽  
Inflammatory Signaling ◽  
Regulation Of Glycolysis ◽  
Shed Light

AbstractSepsis is a heterogeneous syndrome induced by a dysregulated host response to infection. Glycolysis plays a role in maintaining the immune function of macrophages, which is crucial for severely septic patients. However, how the pathways that link glycolysis and macrophages are regulated is still largely unknown. Here, we provide evidence to support the function of KLF14, a novel Krüppel-like transcription factor, in the regulation of glycolysis and the immune function of macrophages during sepsis. KLF14 deletion led to significantly increased mortality in lethal models of murine endotoxemia and sepsis. Mechanistically, KLF14 decreased glycolysis and the secretion of inflammatory cytokines by macrophages by inhibiting the transcription of HK2. In addition, we confirmed that the expression of KLF14 was upregulated in septic patients. Furthermore, pharmacological activation of KLF14 conferred protection against sepsis in mice. These findings uncover a key role of KLF14 in modulating the inflammatory signaling pathway and shed light on the development of KLF14-targeted therapeutics for sepsis.

scholarly journals The action of metformin on the production of pro-inflammatory cytokines and insulin resistance (NF-kB signal pathway)

2012 ◽  
Vol 58 (2) ◽  
pp. 25-28
Author(s):  
A V Lavrenko ◽  
N L Kutsenko ◽  
L A Kutsenko ◽  
T V Mamontova ◽  
I P Kaĭdashev
Keyword(s):  
Metabolic Syndrome ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Inflammatory Cytokines ◽  
Combined Treatment ◽  
Signal Pathway ◽  
Tnf Alpha ◽  
Peptide Level ◽  
Pro Inflammatory Cytokines

The objective of the present study was to estimate the role of the NF-kB signal pathway in the realization of the anti-inflammatory and insulin-synthesizing activities of metformin in the patients presenting with coronary heart disease (CHD) associated with metabolic syndrome (MS). It was shown that the introduction of a one-month course of metformin therapy in the combined treatment of CHD resulted in the decreased production of pro-inflammatory cytokines, such as IL-1-beta, IL-6, IL-8, and TNF-alpha. Simultaneously, the serum C-peptide level decreased. These effects of metformin were mediated through the NF-kB-signal pathway. It is concluded that the inclusion of metformin in the combined treatment of coronary heart disease in the patients with metabolic syndrome prevent activation of NF-kB under the influence of endogeneous pro-inflammatory cytokines.

Glucocorticoid-induced metabolic syndrome: establishing the role of AgRP

2018 ◽  
Author(s):  
Charlotte Sefton ◽  
Erika Harno ◽  
Alison Davies ◽  
Tiffany-Jayne Allen ◽  
Jonathan R Wray ◽  
...  
Keyword(s):  
Metabolic Syndrome

The role of omentin in inflammation and metabolic syndrome risk assessment in women with PCO-S

2019 ◽  
Author(s):  
Iwona Zieleń-Zynek ◽  
Joanna Kowalska ◽  
Nowak Justyna ◽  
Barbara Zubelewicz-Szkodzińska
Keyword(s):  
Risk Assessment ◽  
Metabolic Syndrome
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